Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Communication Evaluation Research Project Director
$160K - $185K *
Unlock your potential as a Project Director, leading innovative health research initiatives. Drive strategic planning and capture opportunities while managing a dynamic team to tackle complex public h...
2 days ago
Utilities Vulnerability Assessment Engineer
$63K - $111K *
Empower mission success by assessing utility vulnerabilities and enhancing infrastructure resilience against diverse threats. Collaborate with a multidisciplinary team to ensure operational continuity...
2 days ago
Associate Director / Senior Managing Consultant - Financial Services Operations & Technology
$150K - $250K *
Transform financial services by leading complex banking operations and technology projects. Collaborate with clients to enhance performance, drive innovation, and shape a new practice within a dynamic...
2 days ago
$99K - $165K *
Transform sourcing strategies by leading initiatives across key spend categories, collaborating with stakeholders to optimize supplier performance, mitigate risks, and drive cost savings while ensurin...
2 days ago
$137K - $245K *
Shape the future of physical operations by driving AI-powered product innovation. Collaborate across teams to identify customer needs, prototype solutions, and deliver impactful products that enhance...
2 days ago
$110K - $130K *
Shape the future of healthcare by leading complex implementations across provider and payor organizations. Drive project success through collaboration, strategic planning, and innovative solutions whi...
2 days ago
Medical Safety Manager, Ambulatory Monitoring & Diagnostics
$133K - $237K *
Contribute to patient safety by overseeing medical product surveillance, analyzing data, and ensuring compliance with regulations. Collaborate on risk management and support clinical studies to enhanc...
2 days ago
$102K - $184K *
Elevate your career by leading market-level financial reporting and performance management in value-based healthcare. Collaborate with stakeholders to drive insights and outcomes, ensuring disciplined...
2 days ago
$110K - $130K *
Champion privacy solutions by engaging with clients, delivering tailored demos, and driving sales success. Leverage your expertise to influence product development and navigate the intersection of AI...
2 days ago
Sr. Director of Customer Success
$150K - $180K *
Transform customer success strategies to enhance client satisfaction and retention. Lead a dynamic team, driving initiatives that elevate user experience and foster growth within a fast-paced SaaS env...
2 days ago
Clinical Genomics Advanced Practice Provider
$110K - $130K *
Unlock potential by joining a dynamic Clinical Oncology Team, where you'll leverage your oncology and genomics expertise to enhance point-of-care products, drive clinical workflows, and support person...
2 days ago
$150K - $180K *
Accelerate progress at a dynamic engineering team, tackling complex technical challenges while delivering high-quality code. Own architectural decisions and enhance integration across services in a co...
2 days ago
ERP Agile Transformation Delivery Consultant, Senior Associate
$77K - $202K *
Join as a Senior Associate to optimize ERP transformations, analyze client needs, manage workstreams, and mentor junior team members while delivering value through agile methodologies and technology s...
2 days ago
Manager of Client Management, CORE East Segment - Cigna Global Health Benefits (GHB) - Remote
$110K - $130K *
Transform client relationships by leading a dynamic team to achieve financial growth and enhance client experiences across a diverse portfolio. Drive strategic initiatives and foster collaboration to...
2 days ago
$110K - $130K *
Join us to drive sales success by nurturing client relationships and delivering tailored Workforce Management solutions. Collaborate with teams to achieve quotas and develop strategic marketing plans...
Reposted 2 days ago
$170K - $180K *
Transform quality management across renewable energy projects by leading initiatives that enhance processes, ensure compliance, and drive continuous improvement. Collaborate with cross-functional team...
2 days ago
Security Engineer Lead, Security Foundations
$160K - $190K *
Transform security solutions across multiple domains, driving technical direction and collaboration to address high-risk items and enhance Meta's security posture company-wide. Lead cross-functional t...
2 days ago
21GRAMS- Senior Delivery Manager
$95K - $100K *
Join our dynamic team as a Technical Delivery Manager, overseeing AI-driven project delivery across diverse digital platforms. Ensure timely, high-quality outputs while leveraging innovative technolog...
2 days ago
$80K - $95K *
Engage customers through impactful marketing initiatives that drive retention and growth. Collaborate with Customer Success Managers to create compelling stories, manage events, and amplify the voice...
2 days ago
Director, Global HR Operations
$175K - $195K *
Shape the future of global HR operations by enhancing systems and processes for a seamless employee lifecycle. Collaborate cross-functionally to improve workflows, compliance, and service effectivenes...
Reposted 2 days ago
Mortgage Finance Banking Relationship Manager Sr
$104K - $243K *
Join a team that's dedicated to managing commercial banking relationships, focusing on Mortgage Servicing Rights and Warehouse Lending. Drive revenue growth while ensuring compliance and fostering str...
2 days ago
Network Specialist - Launch Team
$100K - $145K *
Join a dynamic team to ensure seamless network connectivity for dock deployments. Collaborate with IT teams, troubleshoot connectivity issues, and enhance customer confidence through effective communi...
2 days ago
Staff Product Manager, Agentic Planning
$168K - $285K *
Elevate the future of software planning by leading a team that integrates human and AI collaboration. Shape product direction, connect work to business priorities, and drive strategic decisions in a d...
2 days ago
Senior Site Reliability Engineer (Sat-Wed, Night Shift)
$120K - $145K *
Join a team that's redefining cloud reliability by enhancing observability, automation, and operational excellence. Collaborate across departments to ensure seamless deployment and management of SaaS...
2 days ago
Registered Nurse (RN) | Surgery
$67K - $100K *
Elevate patient care by developing nursing diagnoses, coordinating interventions, and providing comprehensive support to patients and families. Collaborate with healthcare teams to ensure optimal heal...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.