Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$105K - $140K *

Join us to optimize the commercial operating plan for small accounts, enhancing customer experiences and driving measurable growth through hands-on strategies and collaboration across teams...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$83K - $115K *

Transform service delivery by leading a skilled team of engineers, ensuring operational excellence and customer satisfaction through effective coordination and relationship management. Drive continuou...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$88K - $112K *

Drive the development and execution of a comprehensive enterprise risk management program, collaborating across global functions to enhance risk governance, reporting, and education while maintaining...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

$240K - $285K *

Help us shape a transformative People Operations strategy that drives organizational effectiveness and talent development. Lead initiatives from concept to execution, fostering a culture of accountabi...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Information Technology

$132K - $272K *

Elevate retail partnerships by developing integrated strategies that drive growth and innovation. Collaborate across teams to transform complex opportunities into actionable plans, enhancing commerce...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$139K - $232K *

Unlock potential by providing enterprise architecture leadership for Retail and Consumer Banking. Shape technology strategies and roadmaps across various banking capabilities, ensuring alignment with...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Champion customer success by owning relationships, driving adoption, and ensuring renewals. Leverage deep trust to generate qualified leads while proactively engaging law firm accounts to enhance thei...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$88K - $105K *

Drive the execution of influencer marketing strategies, managing relationships with creators and overseeing performance metrics to maximize ROI. Lead a team while collaborating with cross-functional p...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Join a dynamic team as a senior leader, driving client relationships and revenue growth in lead-generation sectors. You'll manage a diverse portfolio, ensuring lead quality and speed while leveraging...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$200K *

Lead the charge in driving enterprise growth marketing strategies, optimizing pipeline performance, and orchestrating cross-functional initiatives to scale demand generation and revenue outcomes acros...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Join a team that's focused on driving growth and customer satisfaction in the commercial and industrial sector. Leverage your sales expertise to manage accounts, resolve customer issues, and identify...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Help us manage diverse projects that drive strategic growth and collaboration across teams. As a key member of the EPMO, you'll ensure project success through effective stakeholder management and cont...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$116K - $171K *

Lead the charge in optimizing partner experiences and driving program modernization. This role requires strategic project management and a focus on automation to enhance the lifecycle of partnerships...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Transportation

$145K - $175K *

Strategize and execute marketplace growth initiatives on Amazon and TikTok Shop, driving sales and profitability while managing P&L and aligning with omnichannel objectives. Lead operations, performan...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$179K - $224K *

Engage with partner engineering teams to design and prototype integrations that enhance our AI platform. This role demands hands-on engineering, scalable architecture, and translating findings into im...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $125K *

Transform complex commercial casualty claims management by leveraging your expertise in construction-related exposures and litigation. Collaborate with a dedicated team to deliver exceptional outcomes...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$144K - $240K *

Transform healthcare delivery by leading strategic initiatives and optimizing infusion services. Drive client success through expert guidance, operational excellence, and innovative solutions, ensurin...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $150K *

Drive growth and strategy for key telehealth categories by leveraging market insights, customer feedback, and cross-functional collaboration to enhance performance and deliver exceptional customer exp...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$74K - $87K *

Unlock patient access by managing the insurance verification process, addressing barriers to care, and ensuring seamless coordination among stakeholders to facilitate timely therapy access and support...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$72K - $99K *

Unlock the potential of marketing operations by managing our MarTech stack, optimizing processes, and collaborating across teams to drive growth and efficiency in marketing initiatives...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Lead compliance efforts in marketing by ensuring all materials meet legal standards. Collaborate with cross-functional teams to apply guidelines effectively while maintaining a keen attention to detai...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$190K - $210K *

Collaborate with cross-functional teams to drive clinical biomarker strategy and execution, translating discovery insights into actionable approaches that enhance patient outcomes in early neuroscienc...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Take ownership of payroll operations, ensuring accuracy and compliance while leading a team to deliver timely wage payments and manage tax obligations effectively across the organization...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$200K - $250K *

Partner with us to drive growth as our Chief Marketing Officer, leading innovative strategies and systems to generate member acquisition across multiple markets, ensuring sustainable success and perfo...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Business Services

$145K - $180K *

Transform retail operations by serving as the primary SAP POS expert for DoD S/4HANA implementations, ensuring alignment with operational goals and financial reporting while bridging technical teams a...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.