Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$120K - $160K *

Transform communications strategy and execution for a growing organization. Lead branding, messaging, and digital presence to enhance visibility and engagement across diverse audiences, while collabor...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$140K *

Shape the future of public safety SaaS by leading a high-performing sales team, driving growth, and executing strategic initiatives in a rapidly evolving market. Collaborate cross-functionally to enha...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Partner with us to drive revenue growth and strategic account management across a diverse portfolio. You'll own the full sales cycle, collaborate with cross-functional teams, and build lasting relatio...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $120K *

Empower our brand by driving in-store execution, building relationships, and enhancing customer experiences across key accounts. Collaborate with teams to optimize sales and training while ensuring br...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$170K - $230K *

Pioneer a high-performing sales team, driving revenue growth through strategic leadership and client engagement. Shape the future of our corporate sales efforts by optimizing processes and fostering c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$160K - $193K *

Shape the future of autonomous vehicle testing by leading a team to develop and implement innovative test strategies, ensuring safety and performance standards are met across multiple vehicle programs...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $150K *

Empower our growth by leading revenue marketing initiatives that drive predictable pipeline for sales. You'll strategize and execute impactful programs across events, campaigns, and account-based mark...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Reimagine medical communication by leading a team of writers to craft regulatory and scientific documents. Oversee projects, ensuring clarity and quality for diverse audiences while adhering to timeli...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Elevate product design by leading innovative initiatives, guiding cross-functional teams, and shaping user experiences from concept to delivery. Drive design excellence and foster a culture of feedbac...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $115K *

Partner with us to lead complex Sage Intacct implementations, guiding clients through analysis, design, and optimization. Leverage your expertise to enhance client relationships and drive successful p...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $125K *

Contribute to acquiring and managing data partnerships, collaborating with product teams to prioritize and improve dataset quality, while leveraging AI to enhance data processes and achieve business o...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$127K - $222K *

Champion the technical backbone of live sports broadcasts, ensuring seamless signal flow and infrastructure management. Collaborate across teams to deliver high-quality productions while thriving in d...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$74K - $98K *

Champion regulatory audit excellence by leading PACE audits, ensuring compliance, and driving cross-functional collaboration to enhance operational readiness and continuous improvement across the orga...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$173K - $288K *

Empower your career by owning global tax provisions and compliance. Lead audits, drive process improvements, and support M&A initiatives while collaborating across teams to enhance tax strategies and...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$148K - $247K *

Join a team that's driving digital transformation in financial services. Leverage your expertise in Appian to design and optimize workflows, collaborate with stakeholders, and enhance client-centric s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$108K - $145K *

Drive impactful pricing strategies and cost analysis for complex proposals, ensuring compliance and competitiveness. Collaborate with cross-functional teams to deliver actionable insights and recommen...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$179K - $224K *

Join a team that's dedicated to delivering high-quality member-facing systems. As an Engineering Manager, you'll lead a squad through the entire development lifecycle, ensuring accountability, quality...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$124K - $223K *

Shape the future of pricing strategy by leading a dynamic team to optimize profitability and drive strategic decisions across SaaS and services. Collaborate with executives to enhance customer value a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$160K - $193K *

Lead the charge in HiL testing for autonomous trucks, guiding a team to ensure robust verification and validation. Shape the test strategy, align with safety standards, and collaborate across teams to...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $198K *

Drive revenue growth by optimizing data systems and processes. Collaborate with cross-functional teams to enhance forecasting, analytics, and AI solutions, ensuring informed business decisions and str...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $179K *

Shape the future of gameplay animation by creating high-quality character animations, collaborating with cross-functional teams, and driving the artistic vision while working independently to resolve...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Media

$135K - $160K *

Champion modernization initiatives by designing and overseeing transformation solutions, integrating cutting-edge GenAI technology, and ensuring alignment with business objectives to drive impactful m...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$109K - $207K *

Drive strategic enterprise sales to Fortune 100/500 companies, leveraging strong negotiation skills and a proven track record to exceed quotas in a dynamic and collaborative environment...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Join a team that's redefining oncology care by overseeing clinical standards, evaluating therapies, and engaging with providers. You'll play a key role in shaping patient eligibility and treatment pro...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$129K - $168K *

Manage and elevate accounts payable operations by leading teams, optimizing workflows, and ensuring compliance with best practices. Collaborate cross-functionally to drive operational excellence and e...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.