Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$100K - $200K *

Join a team that's driving growth through performance marketing. You'll lead the sales process, from discovery to closing, while leveraging a dedicated operations team to maximize client engagement an...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$200K - $250K *

Lead identity and permissions management as you shape a user-centric platform, balancing complexity with simplicity to empower teams and drive product vision in a dynamic fintech environment...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$145K - $185K *

Shape the future of channel marketing by driving co-marketing strategies with partners in the South Central region. Collaborate to enhance pipeline growth and ensure ROI through innovative field progr...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$70K - $99K *

Empower our digital marketing efforts by managing website updates, social media, and email campaigns. Analyze performance data to drive actionable insights, enhance engagement, and support organizatio...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $100K *

Optimize customer onboarding by managing end-to-end implementations, translating solution designs into actionable configurations, and ensuring seamless project execution while fostering strong client...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$126K - $164K *

Empower your career by leading the design and implementation of protective relay systems. Collaborate with a dynamic team to enhance system protection across various energy sectors, ensuring complianc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $110K *

Join a team that's dedicated to transforming complex scientific data into clear, impactful content. Collaborate with peers to ensure accuracy and adherence to guidelines while developing crucial mater...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Unlock potential by leading analytics initiatives, transforming data into actionable insights, and mentoring junior analysts. Collaborate with stakeholders to enhance reporting solutions and drive ope...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $148K *

Transform your career by enhancing Procure-to-Pay systems, collaborating with Finance teams, and driving automation initiatives. Leverage your analytical skills to improve processes and ensure complia...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$180K - $230K *

Join a dynamic team as you lead engineering efforts to develop an AI Patient Engagement Agent, transforming clinical trials by automating patient interactions and enhancing operational efficiency for...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Innovate technical SEO strategies to enhance global web performance, ensuring optimal search visibility and user experience. Collaborate with cross-functional teams to identify and resolve technical i...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$87K - $97K *

Shape the future of marketing analytics by building robust data pipelines and automating reporting workflows. Collaborate with cross-functional teams to enhance data quality and leverage AI tools for...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$120K - $160K *

Architect innovative software solutions, guiding technical direction and design standards. Collaborate across teams to ensure alignment with business objectives while mentoring engineers and establish...

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $150K *

Champion social strategy and community engagement, driving impactful growth across multiple channels. Lead a dynamic team to create culturally relevant content, leveraging AI for efficiency and innova...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$168K - $285K *

Shape the future of corporate governance and securities law by leading public company reporting and compliance initiatives. Collaborate with cross-functional teams to provide strategic legal guidance...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $140K *

Elevate customer experience by optimizing Zendesk for a scaling organization. Collaborate with leadership to enhance routing, AI tools, and workflows, ensuring efficient support operations and data-dr...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Transportation

$90K - $95K *

Elevate your career by managing advanced accounting and reporting activities for a dynamic label. Collaborate with cross-functional teams to ensure compliance and deliver timely financial insights tha...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$85K - $100K *

Join a dynamic healthcare team as you manage complex patient populations, collaborating with physicians and nurses to deliver high-quality care. Utilize your expertise in a predominantly outpatient se...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Optimize the workflow and execution of Field Install Teams across multiple markets, ensuring effective project management, cost savings, and team development while maintaining high standards in visual...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Unlock growth potential by managing strategic accounts and cultivating executive relationships. Drive revenue through tailored strategies and consultative selling, while aligning cross-functional team...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a team that's redefining marketing automation. As a key player, you'll oversee the optimization of our global platform, ensuring smooth data flows and empowering marketers through training and te...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Empower teams by enhancing technical capabilities across multiple sites, driving operational excellence through hands-on training and support. Engage in troubleshooting and continuous improvement to e...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$95K - $145K *

Unlock potential by leading compliance initiatives in chemicals and recycling. Collaborate across teams to ensure regulatory adherence, mitigate risks, and support sustainability goals while engaging...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Take ownership of the Microsoft Security Solutions area, driving strategy and sales execution. Lead cross-functional teams to optimize performance, align priorities, and translate market opportunities...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$65K - $116K *

Manage multiple locations, ensuring exceptional service and operational excellence. Lead teams, implement strategies for growth, and analyze performance metrics to drive profitability while adhering t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Transportation

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.