Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$100K - $200K *
Join a team that's driving growth through performance marketing. You'll lead the sales process, from discovery to closing, while leveraging a dedicated operations team to maximize client engagement an...
2 weeks ago
Senior Product Manager - Users
$200K - $250K *
Lead identity and permissions management as you shape a user-centric platform, balancing complexity with simplicity to empower teams and drive product vision in a dynamic fintech environment...
Reposted 2 weeks ago
Senior Channel Field Marketing, South Central
$145K - $185K *
Shape the future of channel marketing by driving co-marketing strategies with partners in the South Central region. Collaborate to enhance pipeline growth and ensure ROI through innovative field progr...
2 weeks ago
Digital Marketing Channel Specialist
$70K - $99K *
Empower our digital marketing efforts by managing website updates, social media, and email campaigns. Analyze performance data to drive actionable insights, enhance engagement, and support organizatio...
2 weeks ago
$80K - $100K *
Optimize customer onboarding by managing end-to-end implementations, translating solution designs into actionable configurations, and ensuring seamless project execution while fostering strong client...
2 weeks ago
Lead System Protection Engineer
$126K - $164K *
Empower your career by leading the design and implementation of protective relay systems. Collaborate with a dynamic team to enhance system protection across various energy sectors, ensuring complianc...
2 weeks ago
Medical Writer, Medical Communications
$80K - $110K *
Join a team that's dedicated to transforming complex scientific data into clear, impactful content. Collaborate with peers to ensure accuracy and adherence to guidelines while developing crucial mater...
Reposted 2 weeks ago
Epic Clinical Sr. Reporting Business Analyst
$95K - $115K *
Unlock potential by leading analytics initiatives, transforming data into actionable insights, and mentoring junior analysts. Collaborate with stakeholders to enhance reporting solutions and drive ope...
2 weeks ago
Business Systems Analyst, Procure-to-Pay
$100K - $148K *
Transform your career by enhancing Procure-to-Pay systems, collaborating with Finance teams, and driving automation initiatives. Leverage your analytical skills to improve processes and ensure complia...
2 weeks ago
Director, Engineering (AI Patient Engagement Platform)
$180K - $230K *
Join a dynamic team as you lead engineering efforts to develop an AI Patient Engagement Agent, transforming clinical trials by automating patient interactions and enhancing operational efficiency for...
2 weeks ago
$90K - $110K *
Innovate technical SEO strategies to enhance global web performance, ensuring optimal search visibility and user experience. Collaborate with cross-functional teams to identify and resolve technical i...
2 weeks ago
Marketing Data Analytics Engineer (US)
$87K - $97K *
Shape the future of marketing analytics by building robust data pipelines and automating reporting workflows. Collaborate with cross-functional teams to enhance data quality and leverage AI tools for...
2 weeks ago
$120K - $160K *
Architect innovative software solutions, guiding technical direction and design standards. Collaborate across teams to ensure alignment with business objectives while mentoring engineers and establish...
2 weeks ago
$120K - $150K *
Champion social strategy and community engagement, driving impactful growth across multiple channels. Lead a dynamic team to create culturally relevant content, leveraging AI for efficiency and innova...
2 weeks ago
$168K - $285K *
Shape the future of corporate governance and securities law by leading public company reporting and compliance initiatives. Collaborate with cross-functional teams to provide strategic legal guidance...
2 weeks ago
$100K - $140K *
Elevate customer experience by optimizing Zendesk for a scaling organization. Collaborate with leadership to enhance routing, AI tools, and workflows, ensuring efficient support operations and data-dr...
2 weeks ago
$90K - $95K *
Elevate your career by managing advanced accounting and reporting activities for a dynamic label. Collaborate with cross-functional teams to ensure compliance and deliver timely financial insights tha...
2 weeks ago
Advanced Practice Provider - Clinical Research Oncology
$85K - $100K *
Join a dynamic healthcare team as you manage complex patient populations, collaborating with physicians and nurses to deliver high-quality care. Utilize your expertise in a predominantly outpatient se...
2 weeks ago
District Field Install Manager
$80K - $95K *
Optimize the workflow and execution of Field Install Teams across multiple markets, ensuring effective project management, cost savings, and team development while maintaining high standards in visual...
2 weeks ago
$100K - $120K *
Unlock growth potential by managing strategic accounts and cultivating executive relationships. Drive revenue through tailored strategies and consultative selling, while aligning cross-functional team...
Reposted 2 weeks ago
Marketing Automation Systems Analyst
$80K - $95K *
Join a team that's redefining marketing automation. As a key player, you'll oversee the optimization of our global platform, ensuring smooth data flows and empowering marketers through training and te...
Reposted 2 weeks ago
Regional Technical Leader - North Region (US)
$100K - $120K *
Empower teams by enhancing technical capabilities across multiple sites, driving operational excellence through hands-on training and support. Engage in troubleshooting and continuous improvement to e...
2 weeks ago
Program Manager, Chemicals & Recycling Compliance
$95K - $145K *
Unlock potential by leading compliance initiatives in chemicals and recycling. Collaborate across teams to ensure regulatory adherence, mitigate risks, and support sustainability goals while engaging...
2 weeks ago
Global Security Solutions Lead
$150K - $180K *
Take ownership of the Microsoft Security Solutions area, driving strategy and sales execution. Lead cross-functional teams to optimize performance, align priorities, and translate market opportunities...
2 weeks ago
$65K - $116K *
Manage multiple locations, ensuring exceptional service and operational excellence. Lead teams, implement strategies for growth, and analyze performance metrics to drive profitability while adhering t...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.