Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Global Compensation Partner
$130K - $160K *
Unlock potential by leading global compensation strategies across multiple regions. Collaborate with HR and business leaders to execute merit cycles, benchmark roles, and innovate with AI tools to enh...
2 days ago
Supply Chain/Vendor Management
$125K - $225K *
Transform supply chain operations by managing vendor performance, logistics, and material tracking for a complex industrial project. Collaborate with cross-functional teams to ensure timely delivery a...
2 days ago
$103K - $181K *
Lead the charge in implementing comprehensive security measures for a large-scale defense project, ensuring the protection of personnel, facilities, and sensitive information while collaborating with...
2 days ago
$112K - $196K *
Champion a proactive safety culture by leading safety, health, and environmental activities for a major industrial infrastructure project. Oversee contractor performance, conduct inspections, and ensu...
2 days ago
Risk Manager (Risk Register/Mitigation)
$125K - $225K *
Champion risk management strategies for a large-scale industrial project, collaborating with multidisciplinary teams to identify and mitigate risks, ensuring informed decision-making and project succe...
2 days ago
$63K - $111K *
Elevate project execution by supporting engineering and construction teams in delivering complex industrial infrastructure projects through technical coordination and quality assurance activities...
2 days ago
Deputy PM - Construction Manager, Senior
$125K - $225K *
Oversee complex industrial construction projects, ensuring safety, quality, and timely completion. Lead multidisciplinary teams, manage contractor performance, and coordinate with stakeholders to achi...
2 days ago
Senior - Administrative Assistant
$63K - $111K *
Join a team that's dedicated to providing top-notch administrative support to program leadership and project personnel, ensuring smooth operations and effective communication across multidisciplinary...
2 days ago
$102K - $193K *
Elevate your career by leading a dynamic sales team, driving growth through strategic partnerships, and executing innovative healthcare solutions while achieving personal and team sales goals in a col...
2 days ago
Registered Nurse (RN) FLOAT | Med Surg
$71K - $107K *
Champion exceptional patient care by delivering comprehensive nursing services, developing care plans, and collaborating with healthcare teams to ensure optimal health outcomes and support for patient...
2 days ago
Registered Nurse (RN) Case Manager | Avera Health Plans Medical Management
$64K - $96K *
Lead the charge in providing comprehensive case management for chronic conditions, collaborating with healthcare teams to optimize care plans and improve patient outcomes in a cost-effective manner, i...
Reposted 2 days ago
$210K - $250K *
Join a dedicated team providing comprehensive medical care and education to patients. Assess, diagnose, and treat with a focus on quality and safety, while collaborating with healthcare professionals...
2 days ago
$210K - $250K *
Transform patient care by providing comprehensive medical evaluations, diagnoses, and treatments. Collaborate with healthcare teams to enhance health education and ensure quality care while adhering t...
2 days ago
Registered Nurse (RN) | Surgery
$67K - $100K *
Optimize patient care by delivering comprehensive nursing services, developing care plans, and collaborating with healthcare teams to ensure holistic support for patients and their families. Join us i...
2 days ago
$190K - $230K *
Join a team that's driving innovation in biopharma partnerships. Leverage your expertise to identify and advance strategic opportunities, influence cross-functional decisions, and manage alliances tha...
2 days ago
Facility Coding Quality Integrity Analyst - Inpatient
$73K - $110K *
Shape the future of coding quality by overseeing audits, developing guidance, and collaborating with teams to enhance accuracy and compliance in healthcare coding practices...
2 days ago
Manager Endpoint Administrator - Remote US
$110K - $130K *
Shape the future of endpoint management by overseeing timely delivery of equipment, ensuring operational stability, and enhancing user satisfaction through effective personnel management and technical...
Reposted 2 days ago
$133K - $173K *
Shape the future of AI governance by designing frameworks and policies that ensure responsible innovation and effective risk management across the enterprise. Collaborate with cross-functional teams t...
2 days ago
Blackbaud Advisory+ Consultant - Raiser's Edge NXT
$77K - $104K *
Join a team that's dedicated to enhancing customer success with Raiser’s Edge NXT. As an Advisory+ Consultant, you'll provide expert guidance, optimize software use, and foster strong relationships to...
2 days ago
Director, Strategic Advisory Services - Theranostics, Radiopharmaceuticals, and Oncology
$156K - $235K *
Accelerate your career by leading Theranostics initiatives within a national healthcare advisory team. Collaborate with executives to enhance patient outcomes and operational performance through strat...
2 days ago
Clinical Applications Specialist, Invasive Cardiology - Houston, TX
$90K - $110K *
Champion clinical education and training by delivering expert knowledge and support to enhance user competencies and optimize patient care within a defined territory. Build strong relationships with s...
2 days ago
Sr Global Product Manager, Digital Solutions - Surgical & Procedural Care
$149K - $224K *
Lead the charge in shaping digital solutions for perioperative workflows, driving strategy and execution across cross-functional teams to enhance clinical outcomes and operational efficiency in surgic...
2 days ago
Clinical Applications Specialist, Invasive Cardiology
$92K - $138K *
Elevate your career by delivering expert clinical education and training. Drive customer success through hands-on support and relationship building, optimizing product adoption and enhancing patient c...
2 days ago
Biomedical Equipment Technician 2
$65K - $98K *
Reimagine service excellence by diagnosing and repairing complex biomedical equipment, ensuring safety and compliance, and fostering strong relationships with customers and teams to drive overall sati...
Reposted 2 days ago
Senior Director of Strategy - Women's Health
$176K - $264K *
Optimize product management for Women's Health in North America, driving strategy, revenue growth, and market share. Collaborate with stakeholders to tailor solutions and enhance customer insights, en...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.