Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$79K - $99K *
Elevate your career by executing and advancing a dynamic organic social strategy. Collaborate with cross-functional teams to create engaging content that resonates with audiences and drives brand rele...
Yesterday
Transaction Management Director - Healthcare
$175K - $220K *
Shape the future of healthcare real estate by leading a dynamic transaction management team. Oversee negotiations, staff development, and strategic planning to drive client success and enhance operati...
Yesterday
Dental Field Trainer - Chicago
$80K - $95K *
Drive impactful training and coaching for dental practices, enhancing adoption of digital workflows and intraoral scanning. Collaborate with clinicians and leaders to ensure operational readiness and...
Yesterday
$170K - $230K *
Join a team that's redefining SoC design by owning subsystem development, integrating third-party IP, and optimizing PPA for next-gen architectures. Contribute across all design stages and drive impac...
Yesterday
Senior Sales Compensation Analyst - Software Sales
$110K - $130K *
Drive sales performance by managing comprehensive compensation strategies that align with company goals. Collaborate across teams to design and implement effective plans, analyze data trends, and ensu...
Reposted yesterday
Senior Specialist, Regulatory Operations
$122K - $143K *
Innovate regulatory operations by managing submission preparation and execution, ensuring compliance with FDA and ICH standards. Collaborate cross-functionally to support complex filings and maintain...
Yesterday
Account Manager, DNA Synthesis - SouthEast
$100K - $120K *
Drive revenue growth by managing key customer relationships and delivering accurate forecasts. Collaborate with teams to support product development and ensure compliance with industry standards while...
Yesterday
Associate, Strategic Finance & Corporate Development
$115K - $140K *
Reimagine financial strategy as you drive analytical rigor and strategic clarity in a high-impact role. Collaborate with cross-functional teams to support growth initiatives and shape the future of a...
Yesterday
$164K - $262K *
Take ownership of software architecture and development to create scalable, user-centric applications. Lead comprehensive development initiatives while optimizing performance and mentoring engineers i...
Reposted yesterday
Senior System Software Engineer - Datacenter Power Management
$224K - $431K *
Innovate cutting-edge software for data center power management, spanning architecture, firmware, and AI workloads. Drive product lifecycle from design to deployment, enhancing performance and energy...
Yesterday
$86K - $99K *
Champion aggressive sales growth by building strategic relationships and generating leads in the insurance housing sector. Drive market share expansion through effective communication and innovative s...
Yesterday
$110K - $130K *
Empower your career by driving strategic sales initiatives within large healthcare organizations. Own the full sales cycle, build executive relationships, and position a leading clinical collaboration...
Yesterday
$87K - $157K *
Transform the Naval Enterprise Network through Model-Based Systems Engineering, utilizing SysML and CSM tools to develop and manage system models, requirements, and designs while collaborating with st...
Yesterday
$107K - $195K *
Explore your career as an Energy Market Analyst, supporting independent power producers and utilities through market analysis, asset valuation, and strategic advisory services in the North American en...
Yesterday
Senior Analyst, Executive Underwriting Priorities
$64K - $173K *
Join a team that's dedicated to enhancing decision-making through data analysis and operational support. This role involves investigating pricing anomalies, collaborating with stakeholders, and delive...
Yesterday
Lead Director - Network Core Infrastructure Operations
$144K - $288K *
Engage in a pivotal leadership role overseeing core network infrastructure operations. Drive stability, performance, and security across WAN and LAN environments while mentoring a skilled team and man...
Reposted yesterday
Project Manager 2, Patient Monitoring (Northeast and Mid-Atlantic Region)
$85K - $125K *
Collaborate with cross-functional teams to lead large-scale healthcare projects, ensuring timely installation and customer satisfaction. Manage project scope, timelines, and resources while communicat...
Yesterday
Software Engineer II (Remote in United States)
$108K - $130K *
Innovate your career by delivering robust software solutions, collaborating across teams, and enhancing code quality. This role empowers you to tackle technical challenges while mentoring junior engin...
Yesterday
Litigation Claims Adjuster, Trucking
$80K - $95K *
Lead the charge in managing litigated claims, evaluating liability, and negotiating settlements. Collaborate with teams to enhance processes while ensuring compliance and maintaining strong relationsh...
Yesterday
$170K - $195K *
Drive operational excellence by leading client success, operations, and implementation efforts. Cultivate teams, streamline processes, and ensure high-quality delivery for enterprise clients, all whil...
Reposted yesterday
Senior Director, Product Management - Unified Communications
$221K - $290K *
Lead a high-performing team to execute the Unified Communications product roadmap, aligning strategic direction with measurable outcomes while coordinating cross-functional efforts to deliver innovati...
Yesterday
Platform Creator Activation Specialist
$85K - $96K *
Empower culinary creators by facilitating their onboarding and growth. As a key member of the Chef Success team, you'll support new platform creators, ensuring a smooth transition and fostering their...
Yesterday
Vice President, Trust Services
$204K - $240K *
Shape the future of trust services by leading strategic initiatives, managing partnerships, and driving revenue growth. Collaborate with cross-functional teams to enhance client experiences and delive...
Yesterday
$70K - $117K *
Join our team as a Technical Business Analyst, bridging business needs and technical solutions. Drive data-driven projects, optimize processes, and enhance reporting for diverse clients while collabor...
Yesterday
$110K - $130K *
Lead the charge in optimizing utility IT/OT solutions, aligning technology with business needs. Collaborate across teams to enhance AMI projects, mentor peers, and ensure compliance with industry stan...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.