Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$185K - $344K *

Join a team that's redefining market access through innovative data partnerships. Lead strategic collaborations, ensure data compliance, and drive insights that enhance decision-making and patient ser...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion the clinical supply chain for late-stage oncology trials, ensuring seamless operations and communication between sites, suppliers, and stakeholders. Drive continuous improvement and complianc...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$105K - $130K *

Analyze financial performance and drive insights to enhance profitability. Collaborate with cross-functional teams to develop budgets, forecasts, and reports, ensuring consistent financial processes a...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Transform production planning by leading a dynamic team to optimize non-sterile compounded production. Drive strategic planning, manage capacity, and ensure alignment with demand forecasts while foste...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$125K - $188K *

Empower a high-performing tech team by leading the development of scalable web applications. Drive project delivery, mentor developers, and ensure compliance in a dynamic, regulated environment while...

Reposted yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$124K - $165K *

Drive revenue growth as a key leader guiding a dynamic sales team focused on optimizing customer relationships and expanding market reach through strategic cross-selling initiatives and innovative sal...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$140K - $158K *

Partner with us to enhance design systems by building shared components and patterns. Collaborate with designers and engineers to create accessible, user-friendly interfaces that elevate product exper...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$300K - $350K *

Pioneer sales growth in the cybersecurity sector by acquiring new accounts, nurturing relationships, and exceeding quotas. Leverage your expertise in disruptive solutions and channel partnerships to d...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in establishing a standardized implementation methodology, overseeing complex projects from contract to go-live. Drive team adoption, manage dependencies, and ensure successful transit...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$67K - $100K *

Oversee comprehensive nursing care by developing tailored care plans, providing emotional support, and collaborating with healthcare teams to ensure optimal patient outcomes and safety in a dynamic cl...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Transform your career by leading strategic workforce enablement initiatives. As a Senior Manager, you'll collaborate with senior executives, shape learning strategies, and drive impactful change acros...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Information Technology

$120K - $145K *

Drive impactful organizational transformation by leading complex client engagements, integrating learning and enablement strategies. Collaborate with multidisciplinary teams to enhance workforce capab...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Empower audit teams to excel with a hands-on role that drives software adoption, enhances workflow efficiency, and delivers measurable outcomes. Collaborate across functions to modernize audit practic...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $120K *

Join a team that's dedicated to optimizing sales solutions through technical expertise. Collaborate with cross-functional teams to develop proposals, evaluate technologies, and manage multiple project...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Real Estate & Construction

$100K - $125K *

Build your expertise in financial modeling for multi-million-dollar real estate outsourcing projects. Lead pricing strategies, client interactions, and develop high-quality proposals while managing cr...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Manage strategic accounts in the Midwest, fostering customer relationships and delivering tailored solutions. Lead cross-functional teams to achieve growth targets while maintaining existing business...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Champion clinical trial excellence by managing projects from initiation to completion, ensuring compliance and quality standards while collaborating with cross-functional teams to drive successful out...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Unlock growth by driving revenue from top-tier accounts while nurturing leads. Collaborate with Sales leadership to shape strategy and establish expertise in digital transformation for financial insti...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$74K - $115K *

Join a team that's dedicated to analyzing financial data and trends to drive informed decision-making. You'll develop reports, support budgeting processes, and ensure compliance while collaborating wi...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Advance your career by ensuring optimal performance of critical data center infrastructure. Collaborate with teams to troubleshoot, document, and manage hardware and software systems in a fast-paced e...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$85K - $110K *

Analyze and qualify inbound leads while collaborating with sales teams to drive growth. Engage with prospects, schedule demos, and optimize outreach strategies to enhance sales performance in a fast-p...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$130K - $145K *

Help us design and implement billing solutions for law firms, leveraging your accounting expertise and software skills to streamline time entry, invoicing, and collections processes on the Litify plat...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$125K - $140K *

Optimize your career by managing enterprise-wide database environments, ensuring high availability, executing disaster recovery strategies, and supporting critical operations in a dynamic SaaS ecosyst...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$120K - $160K *

Lead the charge in transforming claims management by leveraging your expertise to drive data-informed decisions, enhance processes, and foster collaboration across teams, ensuring exceptional service...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $150K *

Transform marketing operations by leading complex initiatives, managing workflows, and enhancing digital communications. Collaborate across teams to ensure timely execution of campaigns, events, and p...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.