Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$80K - $95K *
Empower the mission of the US Space Force by providing essential contracting support. Collaborate with a dedicated team to enhance missile defense and space capabilities while ensuring efficient contr...
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Senior Information Systems Engineer
$99K - $156K *
Engineer robust IT systems by managing identity, cloud infrastructure, and automation. Collaborate with cross-functional teams to enhance security and operational efficiency in a fast-paced, remote-fi...
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$115K - $140K *
Help us drive success by coordinating bid opportunities across defense and commercial sectors. You'll manage the entire proposal process, ensuring compliance and collaboration among cross-functional t...
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Facilities Assessment Consultant - Mechanical (East, US)
$70K - $117K *
Unlock potential by conducting comprehensive assessments of mechanical systems across diverse facilities. Collaborate with clients, document findings, and develop cost estimates while ensuring complia...
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Principal Product Manager- Activation
$190K - $210K *
Transform the owner activation journey by streamlining processes from agreement to live listing. Drive metrics on activation rates and retention while collaborating with teams to enhance onboarding ef...
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Talent Development & Community Program Manager
$125K - $135K *
Discover your potential by designing a unified learning and culture experience. Lead talent development initiatives, onboarding, and community programs to foster connection and growth within a dynamic...
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Senior Software Engineer, Consumer
$159K - $254K *
Transform the digital dining experience by leading full-stack development efforts, collaborating with cross-functional teams to innovate and enhance guest interactions through cutting-edge web solutio...
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$100K - $120K *
Transform client engagement by leveraging Instructure products to enhance learning outcomes. Collaborate with stakeholders to implement best practices, drive adoption, and support educational initiati...
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Senior Structural Engineer-Bridge
$88K - $154K *
Join a team that's redefining bridge engineering by delivering innovative designs and solutions. Collaborate on diverse projects, ensuring structural reliability and efficiency while enhancing your ex...
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Account Executive, Mid Market (Northeast)
$152K - $190K *
Champion the future of physical operations by leveraging IoT data to drive business transformation for mid-sized clients. Navigate complex sales processes, engage multiple stakeholders, and educate cu...
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$79K - $99K *
Elevate your career by executing and advancing a dynamic organic social strategy. Collaborate with cross-functional teams to create engaging content that resonates with audiences and drives brand rele...
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Transaction Management Director - Healthcare
$175K - $220K *
Shape the future of healthcare real estate by leading a dynamic transaction management team. Oversee negotiations, staff development, and strategic planning to drive client success and enhance operati...
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Dental Field Trainer - Chicago
$80K - $95K *
Drive impactful training and coaching for dental practices, enhancing adoption of digital workflows and intraoral scanning. Collaborate with clinicians and leaders to ensure operational readiness and...
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$170K - $230K *
Join a team that's redefining SoC design by owning subsystem development, integrating third-party IP, and optimizing PPA for next-gen architectures. Contribute across all design stages and drive impac...
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Senior Sales Compensation Analyst - Software Sales
$110K - $130K *
Drive sales performance by managing comprehensive compensation strategies that align with company goals. Collaborate across teams to design and implement effective plans, analyze data trends, and ensu...
Reposted today
Senior Specialist, Regulatory Operations
$122K - $143K *
Innovate regulatory operations by managing submission preparation and execution, ensuring compliance with FDA and ICH standards. Collaborate cross-functionally to support complex filings and maintain...
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Account Manager, DNA Synthesis - SouthEast
$100K - $120K *
Drive revenue growth by managing key customer relationships and delivering accurate forecasts. Collaborate with teams to support product development and ensure compliance with industry standards while...
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Associate, Strategic Finance & Corporate Development
$115K - $140K *
Reimagine financial strategy as you drive analytical rigor and strategic clarity in a high-impact role. Collaborate with cross-functional teams to support growth initiatives and shape the future of a...
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$164K - $262K *
Take ownership of software architecture and development to create scalable, user-centric applications. Lead comprehensive development initiatives while optimizing performance and mentoring engineers i...
Reposted today
Senior System Software Engineer - Datacenter Power Management
$224K - $431K *
Innovate cutting-edge software for data center power management, spanning architecture, firmware, and AI workloads. Drive product lifecycle from design to deployment, enhancing performance and energy...
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$86K - $99K *
Champion aggressive sales growth by building strategic relationships and generating leads in the insurance housing sector. Drive market share expansion through effective communication and innovative s...
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$110K - $130K *
Empower your career by driving strategic sales initiatives within large healthcare organizations. Own the full sales cycle, build executive relationships, and position a leading clinical collaboration...
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$87K - $157K *
Transform the Naval Enterprise Network through Model-Based Systems Engineering, utilizing SysML and CSM tools to develop and manage system models, requirements, and designs while collaborating with st...
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$107K - $195K *
Explore your career as an Energy Market Analyst, supporting independent power producers and utilities through market analysis, asset valuation, and strategic advisory services in the North American en...
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Senior Analyst, Executive Underwriting Priorities
$64K - $173K *
Join a team that's dedicated to enhancing decision-making through data analysis and operational support. This role involves investigating pricing anomalies, collaborating with stakeholders, and delive...
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What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.