Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$155K - $165K *

Shape the future of retail by driving sales and operational excellence across a high-volume district. Lead and develop Store Managers, ensuring brand consistency and delivering exceptional customer ex...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$231K - $301K *

Lead the charge in compliance strategy for U.S. Commercial and Market Access. Collaborate with senior leaders to guide complex compliance issues, manage risks, and support innovative business objectiv...

United StatesRemote

Reposted 2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead the charge in shaping HR strategies that enhance organizational effectiveness, drive talent development, and foster a culture of excellence while ensuring compliance and promoting positive relati...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $155K *

Innovate and lead the development of a comprehensive IAM program, collaborating across teams to enhance identity governance and security. Manage a skilled team while ensuring compliance and effective...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$220K - $255K *

Shape the future of healthcare by leading strategic payor relationships and driving reimbursement strategies. Collaborate cross-functionally to enhance patient access and optimize coverage for innovat...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$115K - $144K *

Empower your career by leading strategic marketing and sales initiatives across multiple communities, driving occupancy and revenue goals while collaborating with diverse teams to enhance brand positi...

Yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$128K - $268K *

Empower a high-performing sales team to drive client acquisition and growth in the Middle Market segment, ensuring strong financial performance and fostering trusted advisor relationships with clients...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$192K - $288K *

Join us as a strategic partner in global clinical development operations, driving workforce planning, budget management, and continuous improvement initiatives. Collaborate with leadership to enhance...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$97K - $158K *

Optimize client success by leading Sage Intacct implementations in the construction sector. Manage multiple projects, ensuring timely delivery and high satisfaction while mentoring team members and en...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$99K - $138K *

Transform dealer relationships in the Southeast by driving retail growth, onboarding partners, and serving as a trusted advisor. Collaborate cross-functionally to enhance dealer experiences and bring...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $150K *

Lead and manage design-build projects, ensuring timely completion within budget while meeting client objectives and contractual obligations. Oversee scope development, financial performance, and compl...

United StatesRemote

Reposted yesterday

  •   15+ years exp.  •   Transportation

$95K - $115K *

Champion clinical trial success by leading cross-functional teams, ensuring timely project execution, and maintaining high standards of quality and compliance. Collaborate with stakeholders to drive i...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$93K - $191K *

Drive strategic federal contract administration, overseeing complex engagements and advising leadership on compliance, negotiation, and performance to enhance revenue retention and operational success...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$90K - $120K *

Elevate your career by leading clients through the CMMC 2.0 compliance journey. As a key advisor, you'll translate complex regulations into actionable strategies, ensuring audit readiness and security...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Lead and innovate compliance strategies to ensure adherence to ERISA, DOL, and IRS regulations. Drive technology-enabled solutions, manage risk, and enhance operational excellence while coaching compl...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Help us shape the future of financial planning and analysis in a dynamic SaaS environment. Drive forecasting, budgeting, and KPI reporting while collaborating across teams to support growth and M&A in...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $125K *

Lead and manage diverse acoustics projects, mentoring team members while collaborating with top engineers and architects on high-impact designs across various sectors, including healthcare, education...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$80K - $95K *

Manage client engagements end-to-end while mentoring associates and driving team success. Leverage technical expertise to resolve complex tax issues and enhance client service through collaboration an...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$145K - $218K *

Engage with key opinion leaders and site staff to enhance clinical trial execution. Drive site engagement strategies in Neuroscience and Oncology, fostering relationships and addressing enrollment bar...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$98K - $163K *

Analyze and support federal clients in oversight and monitoring of grant programs, ensuring program integrity and accountability. Collaborate with stakeholders to assess risks, develop recommendations...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$125K - $150K *

Drive compliance and accuracy in financial reporting, overseeing SEC filings and governance. Collaborate with leadership to enhance transparency and support strategic initiatives while ensuring adhere...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$175K - $225K *

Champion client success by leading a dynamic team to drive growth strategies, enhance client relationships, and integrate innovative solutions. Influence operational excellence while fostering a cultu...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $130K *

Unlock potential by partnering with clients to deliver tailored finance solutions, optimizing system performance, and enhancing project management activities. Leverage your expertise to drive client s...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$86K - $144K *

Unlock potential by leading the design and development of scalable generative AI services, ensuring architectural integrity and mentoring teams. Collaborate with cross-functional stakeholders to drive...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Elevate enterprise AI initiatives by partnering with clients to drive strategic solutions. Leverage your expertise to engage senior leaders, design impactful demos, and accelerate deal cycles, ensurin...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.