Senior Clinical Trial Manager Jobs

Explore senior clinical trial manager jobs with Ladders, where you can find vetted professional opportunities paying $100,000 or more. Senior Clinical Trial Managers guide clinical studies from planning through closeout, helping ensure trials are conducted ethically, efficiently, and in compliance with applicable regulations and protocols.

What Senior Clinical Trial Managers Do

These leaders oversee trial operations, timelines, budgets, vendors, and study teams. Responsibilities may include coordinating site activation and enrollment, monitoring study progress, managing risks and deviations, reviewing documentation, and communicating updates to sponsors, investigators, and internal stakeholders. The scope of a role varies by employer, therapeutic area, and development phase.

Skills and Experience Employers Seek

Employers commonly look for substantial clinical research experience, strong project and people-management skills, and familiarity with Good Clinical Practice (GCP), clinical trial regulations, and quality systems. Success also depends on clear communication, sound judgment, attention to detail, and the ability to resolve issues across a complex, cross-functional environment. Some positions favor experience with particular therapeutic areas, global studies, or clinical operations platforms.

Career Paths and Opportunities

Senior Clinical Trial Managers work for pharmaceutical and biotechnology companies, contract research organizations (CROs), and other clinical research organizations. Depending on experience and organizational structure, this role can lead to director-level positions in clinical operations or broader clinical development leadership. Browse current opportunities to compare responsibilities, qualifications, work arrangements, and compensation.

Find Senior Clinical Trial Manager Jobs on Ladders

Use Ladders to discover vetted senior clinical trial manager openings with salaries of $100,000 or more. Review each listing for its location, compensation details, required experience, and study responsibilities to find opportunities aligned with your expertise and career goals.

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1
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$171K - $189K *

Drive clinical study operations by managing CROs, vendors, and budgets. Lead cross-functional collaboration to ensure compliance and quality deliverables while mentoring junior team members and enhanc...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in managing complex clinical trials, ensuring timely delivery, budget adherence, and high-quality outcomes while collaborating with multidisciplinary teams and stakeholders to enhance...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Accelerate progress at the forefront of clinical research by leading complex global trials. Collaborate with cross-functional teams and CROs to enhance operational quality, patient enrollment, and tri...

Today

  •   5 - 7 years exp.  •   Staffing

$100K - $140K *

Engage in impactful clinical trial management, overseeing operations and mentoring teams to ensure quality and efficiency in project execution. Collaborate with leadership to drive improvements and ma...

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Accelerate clinical research excellence by leading trial execution, ensuring compliance, and fostering collaboration across multidisciplinary teams to address unmet medical needs and enhance patient o...

Today

  •   5 - 7 years exp.  •   Staffing

$110K - $130K *

Lead cross-functional teams to drive successful oncology clinical trials. Manage project lifecycle from start-up to closeout, ensuring quality outcomes and strategic alignment. Foster team excellence...

Today

  •   5 - 7 years exp.  •   Healthcare

$168K - $188K *

Oversee and manage clinical trials from protocol development to final report, ensuring compliance with GCP and regulatory standards. Collaborate with cross-functional teams to enhance research efficie...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Take ownership of clinical trial operations, leading Phase II/III studies from startup to closeout. Ensure compliance with regulations and GCP while managing cross-functional teams and vendor relation...

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in managing end-to-end Phase 1-3 clinical trials, ensuring operational excellence and compliance while collaborating with cross-functional teams to drive strategic clinical development...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Oversee clinical trial management, ensuring quality deliverables and compliance. Collaborate with teams to design protocols, analyze data, and address challenges, driving successful execution of innov...

Blue Bell, PARemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Champion clinical monitoring excellence by leading project teams, ensuring adherence to standards, and fostering collaboration. Drive operational success through effective oversight, training, and str...

Covington, KYRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Elevate clinical monitoring by leading project management, ensuring compliance with standards, and mentoring teams. Drive operational excellence through effective communication and oversight of metric...

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$163K - $186K *

Transform clinical research by leading global early phase trials, ensuring compliance and optimizing strategies. Collaborate with cross-functional teams to drive study success and enhance patient outc...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$68K - $232K *

Lead the charge in managing complex clinical trials, ensuring compliance and quality across all phases. Collaborate with teams to optimize site performance, drive recruitment strategies, and maintain...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$68K - $232K *

Empower clinical research excellence by leading complex trial management, ensuring compliance, and optimizing site performance. Collaborate with teams to achieve recruitment targets and maintain high...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$68K - $232K *

Take ownership of complex clinical trial management, ensuring compliance and quality across studies. Lead site selection, recruitment strategies, and operational execution while collaborating with cro...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$68K - $232K *

Lead a team to optimize clinical trial execution, ensuring compliance and quality across studies. Collaborate with stakeholders to meet recruitment targets and enhance site performance while managing...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$68K - $232K *

Elevate clinical trial management by leading complex studies, ensuring compliance, and optimizing site performance. Collaborate with teams to drive recruitment strategies and maintain high-quality dat...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$68K - $232K *

Accelerate clinical trial success by leading complex studies, ensuring compliance, and optimizing site performance. Collaborate with teams to meet recruitment targets and maintain high-quality data wh...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$68K - $232K *

Empower clinical research by leading complex trial management and site selection. Collaborate with teams to optimize recruitment strategies, ensure compliance, and drive operational excellence while m...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $175K *

Lead and elevate clinical trial operations, ensuring timely execution and compliance across global studies. Collaborate with cross-functional teams and manage vendors to drive successful outcomes in a...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$145K - $218K *

Join a dynamic team to lead global Phase I-IV clinical trials, ensuring operational excellence and compliance. Oversee strategy, execution, and cross-functional collaboration while managing budgets, t...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$145K - $218K *

Join us in leading global Phase I–IV clinical trials, ensuring operational excellence and compliance. Oversee strategy, manage vendors, and collaborate with cross-functional teams to drive successful...

Philadelphia, PARemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$78K - $156K *

Join a dynamic team as you manage complex commercial contracts, balancing legal and business needs. Collaborate with cross-functional stakeholders to drive negotiations and enhance contracting process...

Durham, NCRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$112K - $222K *

Empower the clinical site management team from initiation to closure, ensuring effective monitoring and sponsor engagement. Drive results while fostering a collaborative and professional environment...

Durham, NCRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Senior Clinical Trial Manager do?question toggle

    A Senior Clinical Trial Manager leads the operational delivery of clinical studies, coordinating timelines, budgets, sites, vendors, and cross-functional teams while helping maintain protocol, quality, and regulatory compliance.

  • What qualifications are typically required for Senior Clinical Trial Manager jobs?question toggle

    Requirements vary, but employers often seek significant clinical research or clinical operations experience, experience managing studies or teams, and knowledge of GCP and applicable clinical trial regulations. Some roles require therapeutic-area or global-trial expertise.

  • Where do Senior Clinical Trial Managers work?question toggle

    They may work for pharmaceutical and biotechnology companies, CROs, and other organizations involved in clinical research. Roles can support studies across a range of therapeutic areas and development phases.

  • How much do Senior Clinical Trial Managers earn?question toggle

    Compensation varies based on employer, location, experience, and role scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check individual listings for salary and compensation details.

  • How can I find Senior Clinical Trial Manager jobs paying $100,000 or more?question toggle

    Browse Senior Clinical Trial Manager listings on Ladders and review each posting’s salary information, qualifications, location, and responsibilities to identify opportunities that fit your background.