Grasp unique opportunities in the scientific realm by exploring high-paying Principal Scientist jobs that offer annual remuneration of over $100,000. Broaden your professional horizons and get closer to your career goals with our advanced search tools for Principal Scientists.
As a Principal Scientist, you will lead innovation, drive scientific research, and contribute to the growth of the scientific community at large. It is a role that combines leadership, in-depth scientific knowledge, and impactful decision-making.
We provide comprehensive job listings, insightful articles, growth opportunities, and a diverse range of resources for Principal Scientists looking to make their next career move.
Principal Scientist, Process Engineering
$110K - $130K *
Execute and lead scientific research in drug formulation and delivery for protein-based therapeutics. Collaborate with cross-functional teams to design, develop, and optimize manufacturing processes...
Yesterday
Principal Development Scientist
$100K - $130K *
Manage the design and delivery of innovative LC/MS systems for bioprocesses, coordinating across teams to transform concepts into operational solutions that enhance analytical performance and technolo...
5 days ago
$116K - $177K *
Unlock your potential by leading interdisciplinary teams in developing innovative research and product solutions within clinical and life sciences, leveraging your expertise in experimental design and...
Reposted yesterday
$90K - $130K *
Innovate by leading the research in affinity-based technologies and separations. Drive advancements in biomaterials and chromatography systems, bridging bioengineering and analytical science to create...
5 days ago
$120K - $150K *
Take ownership of complex field studies proving AI, data, and cloud solutions for marketers. Design experiments, analyze customer data, and mentor junior staff while influencing enterprise-scale decis...
Reposted yesterday
Senior Scientist - Analytical Development
$90K - $120K *
Drive innovative drug development by leading complex R&D efforts, executing experiments, analyzing critical data, and collaborating effectively across teams to ensure product quality and regulatory co...
2 days ago
$80K - $110K *
The Scientist position at Frontage Laboratories involves specializing in LC-MS/MS for quantitative bioanalysis and drug metabolite characterization. The role requires developing and optimizing analyti...
Reposted today
Senior Scientist, Science & Technology
$90K - $120K *
Drive your career forward by leading analytical method development in a dynamic environment. Manage projects, mentor teams, and ensure compliance with cGMP standards. Join us to foster innovation and...
4 days ago
$120K - $150K *
Advance drug discovery by leading innovative research in immunology and immuno-oncology. Collaborate with cross-functional teams to design experiments and develop novel assays, enhancing understanding...
Today
$173K - $272K *
Innovate with us to design advanced digital and semantic technologies that transform pharmaceutical development, improve laboratory workflows, and enhance scientific data integration for next-generati...
2 days ago
$131K - $196K *
Deliver innovative oligonucleotide solutions while leading product development and technical projects. Collaborate in a hands-on lab environment, empowering teams through mentorship and driving excell...
1 week ago
Principal Scientist-Analytical Research & Development (ARD)
$140K - $155K *
Engage in the development and implementation of analytical methods for APIs, ensuring compliance with industry standards. Collaborate with project teams while applying advanced techniques and leading...
3 weeks ago
$150K - $175K *
Support and lead complex hardware/software development projects in life sciences. Oversee planning, execution and collaboration to ensure innovative solutions delivery while managing risks, budgets, a...
2 days ago
Senior Scientist I, Product Development
$150K - $165K *
Transform product development by leading QC method innovation, optimizing processes, and ensuring robust assay transfer from R&D to manufacturing. Collaborate across teams to drive success in bringing...
3 weeks ago
Senior Scientist, Product Development
$95K - $120K *
Engineer innovative synthetic routes for new chemical products, manage multiple R&D projects, and collaborate on scale-up activities. Leverage your expertise to drive product development in a fast-pac...
1 week ago
Principal Scientist 1 - Chemical Research & Development
$100K - $130K *
Empower innovative chemical synthesis and development by optimizing existing routes and designing new methodologies. Collaborate with teams to ensure safe, efficient lab operations while leading proje...
3 weeks ago
Staff Scientist, Surface Chemistry
$158K - $197K *
Develop innovative surface chemistry solutions for next-gen sequencing and multiomics, leading experimental design, collaboration, and product development to enhance cell-material interface applicatio...
Reposted today
Supervising Principal Scientist, Process Development
$90K - $210K *
Reimagine the future of cell therapy as an innovative leader driving process development and optimization. Collaborate across teams and external partners to enhance the Cellares platform while mentori...
4 weeks ago
Senior Scientist, Bioanalytical
$80K - $120K *
Develop innovative LC-HRMS methodologies for metabolite analysis. Lead studies on diverse therapeutic modalities, delivering high-quality reports while collaborating with cross-functional teams to dri...
4 days ago
$70K - $95K *
Unlock your potential in a pivotal role enhancing automation in laboratory workflows, collaborating to translate manual assays to automated platforms, and ensuring compliance for cutting-edge drug dev...
Reposted yesterday
Principal Scientist - BioProcess Development
$140K - $155K *
Transform bioprocess development and optimization for diverse biopharmaceuticals. Lead cross-functional teams, drive technological innovation, and ensure compliance in a dynamic environment, enhancing...
Today
Senior Scientist, Bioanalytical Science
$133K - $157K *
Join a dynamic team to advance preclinical discovery in bioanalytical sciences, optimizing methods and managing studies, while fostering a culture of innovation aimed at improving mental health soluti...
2 weeks ago
$173K - $272K *
Lead transformative projects by leveraging digital technologies to enhance lab automation, data integration, and scientific workflows, enabling innovative research in pharmaceutical development across...
Reposted 2 days ago
$173K - $272K *
Lead the charge in building advanced digital lab environments that integrate AI, robotics, and semantic technologies, transforming pharmaceutical development and enhancing scientific workflows across...
Reposted 2 days ago
Principal AI Scientist and Lead
$130K - $180K *
Lead the development of innovative AI solutions in preclinical research, managing complex predictive models and agentic systems. Collaborate with stakeholders to ensure secure deployment and complianc...
6 days ago
What is the role of a Principal Scientist?
A Principal Scientist typically leads scientific research, explores innovative ideas, and guides a team of scientists towards achieving the organization's scientific goals.
How much does a Principal Scientist earn on average?
The average salary of a Principal Scientist varies depending on the industry and level of experience. However, on Ladders, you can find Principal Scientists jobs that pay over $100,000.
What qualifications are required for Principal Scientist jobs?
Most Principal Scientist roles require at least a Ph.D. in a relevant scientific field along with several years of research experience. Leadership skills and a proven research track record are typically also essential.
Can I find remote Principal Scientist jobs on Ladders?
Yes, on Ladders, you can find both remote and in-office high-paying Principal Scientist jobs.