Grasp unique opportunities in the scientific realm by exploring high-paying Principal Scientist jobs that offer annual remuneration of over $100,000. Broaden your professional horizons and get closer to your career goals with our advanced search tools for Principal Scientists.
As a Principal Scientist, you will lead innovation, drive scientific research, and contribute to the growth of the scientific community at large. It is a role that combines leadership, in-depth scientific knowledge, and impactful decision-making.
We provide comprehensive job listings, insightful articles, growth opportunities, and a diverse range of resources for Principal Scientists looking to make their next career move.
$93K - $156K *
Transform pharmaceutical development by designing scalable synthetic processes. Collaborate with multi-disciplinary teams to innovate and apply synthetic methodologies for diverse drug candidates in a...
Today
$93K - $156K *
Join the Cardiovascular Discovery Biology team to drive drug discovery by identifying and validating therapeutic targets and biomarkers, collaborating across disciplines, and mentoring junior scientis...
1 week ago
Senior Principal Scientist, Agentic Systems Development for Drug Discovery
$168K - $252K *
Elevate drug discovery with AI by developing cutting-edge computational methods. Collaborate with cross-functional teams to enhance scientific workflows and drive productivity through innovative AI so...
2 weeks ago
Principal Information System Engineer
$180K - $196K *
Launch your career by optimizing our IT operations and providing hands-on support for diverse workplace technologies. Collaborate with teams across departments and countries to ensure efficient identi...
2 weeks ago
$110K - $170K *
Engage with cutting-edge synthetic chemistry to expand innovative reaction capabilities, collaborating closely with leadership to drive research from concept to validated results, enhancing the value...
3 weeks ago
Senior Biologist - Protein Engineering
$88K - $161K *
Elevate your career by joining a dynamic Protein Engineering team to develop innovative therapeutic proteins. This role focuses on antibody discovery, requiring creativity and teamwork to tackle chall...
1 week ago
Senior Research Scientist, High Content Imaging
$93K - $156K *
Champion cutting-edge high-content imaging solutions to support small molecule discovery and optimization across therapeutic areas, collaborating across multidisciplinary teams to translate data into...
3 weeks ago
$147K - $193K *
Elevate your career by providing scientific expertise in clinical evaluations and studies. Engage with key departments while driving clinical trial design, execution, and reporting to enhance therapeu...
2 weeks ago
Sr. Scientist, Pharmaceutical Development
$130K - $179K *
Champion drug product development by leading technical strategies, managing cross-functional teams, and ensuring regulatory compliance from discovery through commercialization, all while driving innov...
6 days ago
Sr Product Manager - Proteomics
$130K - $173K *
Elevate product innovation and growth by leading strategy, lifecycle management, and cross-functional collaboration. Drive market-fit strategies for cutting-edge products, enhancing customer value and...
3 weeks ago
Senior Scientist, Analytical Development and Quality Control - Early Phase
$162K - $186K *
Shape the future of drug product analytical development by leading method validation, oversight at CDMO/CRO partners, and ensuring regulatory compliance for innovative oncology and immunology therapie...
2 weeks ago
Principal Scientist, Flow Cytometry
$110K - $166K *
Lead scientific initiatives to advance immuno-oncology projects, guiding teams to achieve excellence in translational research and assay development while ensuring compliance and mentoring junior scie...
Today
Principal Scientist, Flow Cytometry
$110K - $166K *
Help us advance biopharmaceutical research by designing cutting-edge assays and mentoring a talented team. Collaborate on complex projects, ensuring quality and compliance while driving innovations in...
Yesterday
Principal Scientist--Pharmacokinetics, Dynamics and Metabolism
$106K - $176K *
Drive cutting-edge ADME strategies in a collaborative lab environment, influencing drug discovery and development decisions through scientific rigor and impactful experimentation. Provide mentorship a...
2 weeks ago
Senior Scientist, Process Development
$127K - $170K *
Design transformative therapies by optimizing iPSC-derived processes. Collaborate with experts, tackle complex scientific challenges, and contribute to advancing cell therapy from concept to clinic fo...
1 week ago
Senior Biocompatibility Scientist
$110K - $130K *
Champion the advancement of biocompatibility evaluations for medical devices. Lead assessments, develop SOPs, and collaborate across teams to ensure compliance with regulatory standards and enhance pr...
2 weeks ago
Senior Scientist, Quality Control
$90K - $110K *
Oversee testing and analysis of pharmaceutical products and raw materials, ensuring compliance with regulations and standards. Collaborate on process validation and improvement while mentoring junior...
4 days ago
Scientist II, Formulation & Process Development
$80K - $95K *
Lead the charge in pharmaceutical formulation development by collaborating with multidisciplinary teams to create new drug products. Use your expertise to support manufacturing processes and mentor ju...
2 weeks ago
Senior Development Scientist I
$120K - $145K *
Join a dynamic team to develop and optimize clinical NGS assays, enhancing early cancer detection. Drive high-impact projects collaboratively in a regulated environment, ensuring the delivery of robus...
3 weeks ago
$120K - $145K *
Empower innovative engineering solutions by providing expert assessments and support for payload and countermeasure development. Collaborate across teams to ensure program milestones are met and deliv...
2 weeks ago
Senior Scientist - Protein Biochemist
$134K - $181K *
Optimize protein production and purification strategies to advance drug discovery. Collaborate with structural biologists to generate high-quality samples for structural analysis, supporting innovativ...
2 weeks ago
Senior Scientist. Cell Therapy Process Development
$116K - $174K *
Innovate in CAR-T cell therapy process development by leading experiments and optimizing workflows. Collaborate across functions to enhance methodologies and scale up production for life-changing ther...
2 weeks ago
(Senior / Principal) Scientist, RNA Therapeutics
$150K - $180K *
Transform RNA-therapeutics delivery by leading innovative programs from design to in vivo validation, ensuring a comprehensive, hands-on approach to experimental decisions across safety, potency, and...
1 week ago
Scientist, Process Sciences - Analytical Development
$100K - $120K *
Join a team that's passionate about advancing biopharmaceutical development. Collaborate across R&D and Quality to develop and validate analytical methods that ensure the safety and efficacy of innova...
Today
Research Scientist, Data Analysis
$183K - $210K *
Unlock potential by leading data analysis for innovative ultrasound studies. Collaborate with a dynamic experimental team from design to interpretation, driving insights through advanced statistical m...
1 week ago
What is the role of a Principal Scientist?
A Principal Scientist typically leads scientific research, explores innovative ideas, and guides a team of scientists towards achieving the organization's scientific goals.
How much does a Principal Scientist earn on average?
The average salary of a Principal Scientist varies depending on the industry and level of experience. However, on Ladders, you can find Principal Scientists jobs that pay over $100,000.
What qualifications are required for Principal Scientist jobs?
Most Principal Scientist roles require at least a Ph.D. in a relevant scientific field along with several years of research experience. Leadership skills and a proven research track record are typically also essential.
Can I find remote Principal Scientist jobs on Ladders?
Yes, on Ladders, you can find both remote and in-office high-paying Principal Scientist jobs.