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Welcome to Principal Scientist Jobs

Grasp unique opportunities in the scientific realm by exploring high-paying Principal Scientist jobs that offer annual remuneration of …

1,000+ Principal Scientist Jobs

$ Average salary: 155,150

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  • Project Manager - Pharmaceutical

    $90K — $120K *Fairfield, NJ (Essex County)In-Person
    Lead project management initiatives, ensuring effective execution from inception to close for the pharmaceutical sector. Collaborate with cross-functional teams to allocate resources, track progress, and maintain client relationships throughout.
    Requirements: B.Sc. in biological/chemical sciences, 5 years experience, PMP preferred.
  • QC Manager

    $90K — $120K *Germantown, MD (Montgomery County)In-Person
    Lead a high-performing team of QC Analysts to ensure cGMP compliance, maintain laboratory standards, and drive continuous improvement in quality processes within the pharmaceutical and biotech sectors.
    Requirements: BS in Biological Sciences/Bioengineering/Chemistry; 7+ years QC exp; 2+ years supervisory.
  • Global Product Manager - Molecular Diagnostics

    $110K — $125K *Camarillo, CA (Ventura County)In-Person
    Champion the development and execution of the global product roadmap for the Molecular Diagnostics portfolio, influencing cross-functional teams and aligning with strategic business objectives to deliver innovative solutions.
    Requirements: Bachelor's in Microbiology/Biology; 3+ years in product management; MS Office expertise.
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    Senior Energetics Engineer

    $100K — $130K *Jefferson, OH (Ashtabula County)In-Person
    Lead the charge in advancing energetic materials technology by overseeing program execution, driving business growth, and mentoring a team, while ensuring compliance with industry standards and fostering client relationships.
    Requirements: Bachelor's degree; 10+ years experience in munitions/explosives R&D; U.S. Citizenship.
  • Bioprocess Scientist (Downstream) - Advanced Therapies Manufacturing

    $66K — $171K *Lebanon, IN (Boone County)In-Person
    Join a cutting-edge genetic medicines facility to provide technical support for compliant manufacturing of gene therapy drug substances, ensuring quality and innovation from startup through commercial production.
    Requirements: B.S. in relevant engineering/biotech field; 3+ years cGMP manufacturing exp.
  • Senior Scientist, Automation & Informatics

    $117K — $184K *Rahway, NJ (Union County)In-Person
    Advance your career by optimizing laboratory automation systems for high-throughput screening, enhancing workflows, and collaborating with scientists to drive innovative research across various therapeutic areas.
    Requirements: Bachelor's/M.S. degree in relevant field, 7-10 years lab automation experience.
  • Bioanalytical Mass Spectrometry Scientist

    $90K — $120K *King Of Prussia, PA (Montgomery County)In-Person
    Shape discovery and preclinical programs through expert LC-MS/MS bioanalytical assay development, optimization, and execution, leveraging cutting-edge mass spectrometry platforms for diverse therapeutic modalities in a dynamic research environment.
    Requirements: Ph.D. or M.S. in related field, 3+ years LC-MS/MS experience, expertise in Orbitrap & Agilent systems.
  • Distinguished Scientist, Vaccines & Advanced Biotechnologies Process R&D

    $210K — $331K *West Point, PA (Montgomery County)In-Person
    Lead scientific innovation in vaccine drug substance process development, collaborating across teams to drive commercialization while mentoring talent and ensuring regulatory success throughout the product lifecycle.
    Requirements: PhD in relevant field; 15+ years in vaccine DS development; leadership skills.
  • Senior Scientist - Optical Signal Processing

    $139K — $180K *Arlington, VA (Arlington County)In-Person
    Join an innovative team focused on developing advanced optical systems algorithms for target detection. You will leverage your expertise in signal processing and modeling to enhance national security missions while collaborating with top scientists.
    Requirements: MS in Physics/Engineering, 3-5+ years experience, relevant programming skills.
  • Project Compliance Scientist

    $80K — $100K *Orlando, FL (Orange County)In-Person
    Take ownership of compliance initiatives by managing environmental projects, conducting audits, and preparing regulatory documents to ensure adherence to local and federal regulations while mentoring junior team members.
    Requirements: Bachelor's in Environmental Science/Engineering; 5+ years exp.; PE/PG preferred.
  • Associate Principal Scientist, Preclinical Development

    $142K — $224K *Rahway, NJ (Union County)In-Person
    Develop advanced mammalian cell lines through cutting-edge engineering and bioinformatics. Lead large-scale data analysis and NGS characterization while collaborating cross-functionally to optimize therapeutic solutions.
    Requirements: Ph.D. in relevant field; 5+ years experience; Python/R programming; NGS expertise.
  • Materials Scientist (Atom Probe Tomography)

    $90K — $120K *Milpitas, CA (Santa Clara County)In-Person
    Champion precision in Atom Probe Tomography analysis, collaborating with innovative teams to elevate high-impact analytical services. Your expertise in specimen preparation and data analysis will drive advancements in cutting-edge technologies.
    Requirements: MS/PhD in Material Science, 2+ years APT experience, FIB proficiency.
  • Materials Scientist (Atom Probe Tomography)

    $90K — $120K *Milpitas, CA (Santa Clara County)In-Person
    Engineer and optimize cutting-edge Atom Probe Tomography analysis. Collaborate with a dynamic team in a fast-paced research environment focused on precision, ensuring high-quality service delivery to advanced technology clients.
    Requirements: MS/PhD in Materials Science; 2+ yrs APT experience; FIB sample prep.
  • Materials Scientist (Atom Probe Tomography)

    $90K — $120K *Milpitas, CA (Santa Clara County)In-Person
    Accelerate your career as a Scientist supporting cutting-edge Atom Probe Tomography services, collaborating with teams to deliver precise analytical solutions that drive innovation and excellence in high-tech industries.
    Requirements: MS/PhD in Materials Science; 2+ years APT experience; FIB sample prep.
  • Associate Principal Scientist, Upstream Development

    $142K — $224K *Rahway, NJ (Union County)In-Person
    Engineer leading upstream process development for biologics; design, optimize, and scale cell culture processes. Collaborate across teams to drive innovations and support clinical trials while ensuring regulatory compliance and product quality.
    Requirements: Ph.D. in relevant field + 4yrs exp; hands-on cell culture & statistical methods.
  • Technical Manager

    $80K — $90K *Groton, CT (Southeastern Ct County)In-Person
    Empower a collaborative lab environment by leading teams, driving research, and ensuring operational excellence. Oversee GMP/GLP adherence and client relations while managing training, performance, and continuous process improvement initiatives.
    Requirements: M.S./Ph.D. in related field; 3+ years GMP/GLP lab exp.; leadership skills required.
  • Technical Manager

    $80K — $90K *Groton, CT (Southeastern Ct County)In-Person
    Elevate your career by leading laboratory teams to achieve operational excellence, while performing hands-on research and driving process improvements to ensure optimal client satisfaction and safety in a dynamic environment.
    Requirements: M.S. or Ph.D. in related field; 3+ years GMP/GLP lab experience; leadership skills.
  • Senior Environmental Scientist

    $90K — $120K *Houston, TX (Harris County)In-Person
    Unlock growth as a Senior Environmental Scientist, driving project success and client relationships while shaping impactful environmental solutions across diverse sectors. Collaborate and mentor while navigating Texas regulations and expanding market reach.
    Requirements: Bachelor's degree, 10-15 years experience, strong project management, excellent communication.
  • Program Manager

    $90K — $130K *Arlington, VA (Arlington County)In-Person
    Unlock your potential as you manage complex DoD programs, bridging customers and technical teams to deliver innovative solutions from R&D to deployment, while ensuring contract objectives are met effectively and on schedule.
    Requirements: BS/BA, 5-8 years DoD program management, DoD Top Secret clearance.
  • Systems Architect, New Product Development, R&D

    $100K — $130K *Boynton Beach, FL (Palm Beach County)In-Person
    Join a team driving innovation in analytical instruments by defining and evaluating next-gen architectures. Shape scalable designs through first-principles physics and system analysis while collaborating with diverse technical experts.
    Requirements: BS in relevant field, 5+ years in product development, strong modeling skills.
  • Senior Scientist - Target Discovery & Validation - Induced Proximity Platform (IPP)

    $115K — $156K *Burnaby, BCIn-Person
    Empower your career by leading innovative research in target discovery and validation within a collaborative environment. Drive advancements in therapeutic developments in oncology and other key areas through cutting-edge scientific techniques.
    Requirements: PhD in Science or MS with 2+ years exp; expertise in proteomics, flow cytometry.
  • Senior Data Scientist

    $78K — $156K *Austin, TX (Travis County)In-Person
    Lead the charge in analytics to deliver impactful data-driven solutions for cardiac rhythm management projects, influencing key decisions with data insights and advanced analytics techniques.
    Requirements: Bachelor's in STEM, 5+ years data experience, SQL, Python proficiency required.
  • Scientist NA SPR Field Technology

    $70K — $95K *Waterloo, NE (Douglas County)In-Person
    Engage your agronomic expertise to drive innovation in seed production, enhance quality, and implement new technologies. Collaborate with production teams to support sustainable agricultural practices through effective project management and execution.
    Requirements: Graduate degree preferred, 3 years seeds production experience, AI tools expertise.
  • Scientist, Systems Engineering

    $100K — $130K *Plano, TX (Collin County)In-Person
    Champion advanced technology innovations in radar systems and UAS. Lead product development through requirements management, integration, and performance analysis. Collaborate with multi-disciplinary teams to drive project success and deliver exceptional results.
    Requirements: Bachelor's degree + 12 years experience; active secret clearance required.
  • Lead Process Engineer

    $108K — $162K *Frederick, MD (Frederick County)In-Person
    Take ownership of critical process engineering projects, providing technical support for manufacturing operations. Collaborate on system improvements, compliance, and training within a fast-paced biopharmaceutical environment to drive operational excellence.
    Requirements: Bachelor's degree in Engineering or Life Sciences, 5+ years experience, and 3+ years in biotech.
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Project Manager - Pharmaceutical

Company Name
$90K — $120K *
Fairfield, NJ 07004
In-Person
Pharmaceuticals & Biotech
5 - 7 years of experience
Job Description

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FAQ About Principal Scientist Jobs

What is the role of a Principal Scientist?

A Principal Scientist typically leads scientific research, explores innovative ideas, and guides a team of scientists towards achieving the organization's scientific goals.

How much does a Principal Scientist earn on average?

The average salary of a Principal Scientist varies depending on the industry and level of experience. However, on Ladders, you can find Principal Scientists jobs that pay over $100,000.

What qualifications are required for Principal Scientist jobs?

Most Principal Scientist roles require at least a Ph.D. in a relevant scientific field along with several years of research experience. Leadership skills and a proven research track record are typically also essential.

Can I find remote Principal Scientist jobs on Ladders?

Yes, on Ladders, you can find both remote and in-office high-paying Principal Scientist jobs.