Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Director, Applications, Lab Systems
$181K - $291K *
Lead the charge in managing the full systems development lifecycle for enterprise applications, ensuring data quality and integrity while evolving best practices across healthcare operations and suppo...
2 days ago
Medical Director, Clinical Partnerships
$200K - $250K *
Transform provider engagement by leading peer-to-peer conversations and ensuring clinical governance. Leverage your medical expertise to enhance patient safety and optimize drug strategies while repre...
Reposted 4 weeks ago
Manager, Revenue Cycle Operations
$100K - $130K *
Join a dynamic team to lead and enhance billing and coding operations, ensuring quality and compliance across multiple markets. Drive performance, coach leaders, and collaborate cross-functionally to...
3 weeks ago
Senior Product Manager, Catalog
$158K - $166K *
Join a team that's optimizing product data infrastructure to enhance customer trust and accessibility. You'll lead cross-functional initiatives that drive the strategy for catalog attributes, ensuring...
Reposted today
Associate Director, Technical Services - Snacks
$131K - $181K *
Lead the charge in developing technical capability programs that enhance product quality and process efficiency. Manage cross-functional teams to drive innovation, ensure compliance, and foster employ...
1 week ago
Territory Manager, Diabetes (Arlington, VA)
$64K - $110K *
Drive business growth by promoting and supporting diabetes products in your territory. Collaborate with healthcare professionals, manage sales strategies, and provide technical support to enhance pati...
1 week ago
Certified Medical Dosimetrist - Radiation (Remote)
$80K - $95K *
Shape the future of cancer treatment by collaborating with experts to create individualized radiation therapy plans. Leverage advanced tools and techniques in a supportive, fully remote environment fo...
1 week ago
VP - Insurance Services Agency Manager
$145K - $175K *
Lead the future of insurance services by driving portfolio growth, empowering teams, and ensuring exceptional client outcomes across North America. Your strategic vision will shape the insurance progr...
1 week ago
$120K - $147K *
Shape your career by leading data integration initiatives that drive enterprise-wide consistency and governance. Collaborate with stakeholders to deliver trusted, scalable data products while ensuring...
1 week ago
$66K - $102K *
Lead the charge in delivering innovative SAP MDG solutions, leveraging your expertise to design, implement, and optimize data governance processes. Collaborate with cross-functional teams to drive imp...
6 days ago
$73K - $102K *
Shape the future of enterprise technology by leading SAP BTP solutions, driving cloud integration, and ensuring seamless migrations. Collaborate with clients to deliver innovative consulting services...
4 weeks ago
$73K - $102K *
Elevate your career as a Senior SAP Consultant, driving innovative solutions and optimizing processes for our clients. Your expertise will be key in transforming their operational landscapes through s...
4 weeks ago
Contrast Media Clinical Sales Specialist
$97K - $146K *
Partner with us to provide clinical support for contrast media, delivering education and product expertise to healthcare professionals while collaborating with internal teams to enhance patient care a...
2 weeks ago
Senior Director, Business Development
$194K - $266K *
Lead the charge in driving commercial growth by securing high-value partnerships and expanding market presence. Mentor a dynamic team while executing strategic initiatives that enhance client relation...
1 week ago
Sales & Business Development Senior Director- CarepathRx- Evernorth
$197K - $328K *
Shape the future of sales strategies by leading a high-performing team focused on enterprise growth. Drive revenue initiatives through innovative partnerships and collaboration, establishing strong re...
Reposted 2 weeks ago
Manager, Regional Sales - Glaucoma - Central
$160K - $200K *
Shape the future of ophthalmic surgery by leading a high-performing sales team, driving market adoption, and delivering exceptional results in a dynamic environment. Your leadership will cultivate tal...
Reposted 3 days ago
Specialist, Software Engineering
$110K - $183K *
Innovate the future of healthcare technology by developing scalable applications that streamline specialty prescriptions. Collaborate with a skilled team to enhance user experience and drive efficienc...
1 week ago
Sr. Director, Product Management, Consumer
$211K - $373K *
Innovate the consumer experience by leading product strategy and execution. Drive a high-performing team to enhance onboarding and insurance purchasing while aligning with cross-functional partners to...
4 weeks ago
$120K - $145K *
Transform healthcare data solutions by designing scalable architectures, optimizing data pipelines, and ensuring compliance with regulations. Collaborate with cross-functional teams to deliver high-qu...
Reposted 2 days ago
$190K - $300K *
Champion scientific exchange and research initiatives in gastrointestinal immunology, engaging with key scientific leaders to enhance understanding and support clinical trials while fostering an inclu...
1 week ago
Dental, Area Sales Executive - Midwest
$113K - $178K *
Empower dental sales growth by collaborating with leadership to develop effective strategies. Build strong relationships, enhance customer offerings, and drive success across key accounts while leadin...
Reposted 1 week ago
$122K *
Champion clinical excellence by leading large teams, ensuring strategic alignment, and driving patient recruitment while mitigating risks in clinical operations for successful study execution...
1 week ago
Executive Director, Manufacturing
$175K - $210K *
Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...
Yesterday
Physician | Radiation Oncologist
$250K - $300K *
Join a dedicated team to provide comprehensive medical care, ensuring patient safety and health education while collaborating with healthcare professionals to enhance patient outcomes and maintain hig...
3 weeks ago
$130K - $160K *
Lead all HR functions in a dynamic biotech environment, enhancing employee experience and compliance while driving scalable processes and supporting leadership. Engage with teams to foster growth and...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.