Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Consultant - Healthcare Compliance
$100K - $125K *
Empower healthcare compliance by enhancing programs, mitigating risks, and driving operational integrity. Collaborate with diverse clients to deliver tailored solutions in a dynamic regulatory landsca...
3 weeks ago
$110K - $130K *
Drive impactful solutions as you lead integration efforts, enhancing user experiences through collaboration and innovation while managing multiple complex projects and mentoring junior engineers...
4 weeks ago
GU Field Based Marketing Director - Key Customer Team (Remote North East - NY, MA & CT)
$204K - $290K *
Elevate your career by driving strategic engagement with Key Opinion Leaders in oncology. Collaborate with cross-functional teams to enhance brand strategies and execute impactful marketing initiative...
1 week ago
FSP Clinical Research Associate II - U.S. Northeast Region - Multiple Therapies
$80K - $95K *
Champion clinical monitoring and site management processes, ensuring compliance with protocols and regulations. Develop strong relationships with investigational sites while conducting thorough assess...
Yesterday
$90K - $112K *
Empower health transformation by leading a dynamic nursing team, driving operational excellence, and enhancing patient care through innovative practices and data-driven insights. Collaborate with inte...
3 weeks ago
Solution Engineer (Billing Specialist)
$105K - $130K *
Join a team that's redefining billing solutions in the legal sector. Leverage your expertise in law firm financial operations to support sales efforts, conduct client demos, and enhance our innovative...
3 weeks ago
Director, Biologics Process Development
$223K - $233K *
Deliver strategic leadership in biologics process development, overseeing outsourced manufacturing and ensuring alignment with corporate goals while driving technical excellence in late-stage developm...
1 month ago
Head of Emerging & Digital Therapeutics
$190K - $236K *
Develop and implement innovative therapeutic approaches to enhance mental health outcomes. Collaborate across departments to evaluate, integrate, and govern emerging treatments, ensuring clinical feas...
3 weeks ago
$180K - $200K *
Drive compliance excellence by leading regulatory strategy and governance, ensuring scalable infrastructure for service contracts and insurance programs across North America. Collaborate with executiv...
1 week ago
Patient Marketing Lead - Movement Disorders
$192K - $214K *
Join us in shaping the patient marketing strategy for a leading biopharmaceutical asset. Collaborate across teams to enhance patient engagement and create impactful communications that resonate with p...
2 weeks ago
$94K - $130K *
Elevate product outcomes by collaborating with teams to prioritize and define user stories, ensuring alignment with business needs while maximizing value delivery and maintaining product quality throu...
Yesterday
Quality Assurance Senior Manager
$132K - $178K *
Optimize supplier quality oversight by leading cross-functional teams, ensuring compliance with global standards, and driving continuous improvement initiatives to enhance performance and mitigate ris...
Yesterday
$69K - $146K *
Unlock potential by managing pricing and promotion processes, providing analytical support to drive revenue growth. Collaborate with cross-functional teams to evaluate performance and deliver actionab...
2 weeks ago
Associate Director - Clinical Operations - Healthcare
$155K - $259K *
Transform healthcare performance by leading integrated optimization programs that enhance clinical, operational, and financial outcomes for hospitals and health systems. Drive measurable results throu...
3 days ago
$85K - $100K *
Drive clinical excellence by partnering with agency leaders to assess, develop, and deliver tailored education programs for nursing staff, ensuring compliance and enhancing patient care across a netwo...
Yesterday
$118K - $174K *
Architect innovative ERP solutions by translating business needs into technical requirements, ensuring scalability and performance while leading system integration and optimization initiatives for fut...
3 weeks ago
$130K - $200K *
Lead the charge in driving sales performance through strategic account management, collaboration, and innovative program execution within the C&S hospital sector, while fostering relationships and del...
1 week ago
Hemostasis Sales Specialist - Las Vegas Region
$99K - $136K *
Pioneer strategic growth in Hemostasis solutions, driving revenue and market share expansion through complex sales engagements and executive relationships across healthcare systems and laboratories...
2 weeks ago
Senior Director, Entertainment & Sports
$135K - $180K *
Lead strategic partnerships in healthcare, connecting brands with entertainment and sports. Collaborate with teams to develop, negotiate, and execute impactful initiatives that drive brand engagement...
Today
$120K - $145K *
Elevate healthcare reimbursement processes by leading legal strategies on billing disputes and regulatory compliance. Collaborate with teams to create innovative solutions and build legal frameworks t...
1 week ago
Vice President, Revenue Integrity - DRG & DRGV (REMOTE)
$150K - $180K *
Drive your career with a leadership role focused on Revenue Integrity, overseeing strategic direction, performance metrics, and team development to enhance operational efficiency and client satisfacti...
Yesterday
$104K - $153K *
Elevate your career by leading the Inside Sales strategy to drive growth, enhance customer engagement, and develop a high-performing team. Collaborate across functions to optimize processes and delive...
3 weeks ago
$110K - $120K *
Drive growth by managing sales and account strategies in the PA region, leveraging expertise in genomics and synthetic biology to exceed targets and foster strong customer relationships while ensuring...
2 weeks ago
$120K - $130K *
Elevate cross-functional collaboration by managing complex initiatives, ensuring readiness, and driving execution visibility. Foster alignment among teams to achieve business outcomes with predictabil...
3 weeks ago
Principal Architect, Healthcare
$165K - $243K *
Deliver innovative disaster recovery solutions for healthcare systems, ensuring compliance and resilience for clinical workloads. Collaborate with cross-functional teams to address complex challenges...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.