Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$108K - $135K *

Unlock your potential by driving sales success in specialty biopharmaceuticals. Collaborate with healthcare professionals to enhance patient outcomes and execute strategic business plans within primar...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$119K - $186K *

Champion the evolution of global AI governance and responsible data practices, ensuring compliance with regulations while driving operational efficiencies across cross-functional teams in a dynamic en...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$250K - $275K *

Join us to lead clinical operations for a multi-state virtual care team, ensuring high-quality, timely care. This role combines direct patient care, administrative leadership, and strategic oversight...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $193K *

Join a team that's driving innovation in R&D and Regulatory processes. Leverage your Veeva RIM expertise, manage global compliance systems, and implement solutions that meet dynamic business needs whi...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $213K *

Transform customer engagement by leading omnichannel marketing strategies, collaborating with cross-functional teams, and leveraging data insights to enhance HCP and patient experiences in the pharmac...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$149K - $202K *

Transform the HCP launch landscape by leading innovative marketing initiatives for a groundbreaking treatment in Sjögren's disease. Collaborate cross-functionally to engage healthcare professionals an...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Drive the development and execution of U.S. pricing and contracting strategies, optimizing patient access and revenue performance. Collaborate across functions to ensure successful commercialization a...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Transform healthcare engagement by driving commercial performance and building strong relationships with providers. Collaborate cross-functionally to support product launches and ensure patient access...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$78K - $206K *

Unlock potential by leading clinical performance improvement projects for Medicare Provider Collaboration groups. Collaborate with teams to enhance population health outcomes, focusing on Stars qualit...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform healthcare delivery by leading operations for a growing telehealth practice. Collaborate with clinical teams to enhance patient care through innovative solutions and efficient workflows, ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $190K *

Unlock your potential by engaging key Gastroenterology stakeholders, driving product utilization, and exceeding sales goals through strategic collaboration and compliance in a dynamic healthcare envir...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Champion growth by leading national accounts, driving strategy, and enhancing partnerships with specialty distributors and GPOs. Leverage expertise to ensure product availability and exceed corporate...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$119K - $186K *

Manage legal services for indirect sourcing, delivering strategic counsel and project management. Negotiate vendor agreements and ensure compliance while collaborating with stakeholders to support bus...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$262K - $284K *

Optimize pediatric drug development strategies as a clinical pharmacology leader, overseeing pharmacometric analyses and regulatory submissions, while translating complex data into actionable decision...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$104K - $141K *

Elevate supplier quality management in R&D by ensuring compliance, data integrity, and continuous improvement across the supplier lifecycle, collaborating with cross-functional teams to support our mi...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Transform healthcare by building strong relationships with key oncology stakeholders. Drive product promotion and exceed performance goals while ensuring patient access to innovative therapies in a dy...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$113K - $142K *

Lead the charge in driving sales growth and market share in the Urology sector. Build strong relationships, leverage clinical expertise, and navigate the healthcare landscape to exceed objectives whil...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Lead the execution of innovative topicals projects, ensuring timely delivery and quality. Collaborate across teams to streamline processes and enhance product development, driving growth in a fast-pac...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Transform endpoint management by designing and deploying solutions across a vast device estate. Collaborate with cross-functional teams to ensure security, compliance, and reliability while leveraging...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$140K - $150K *

Join a team that's dedicated to transforming addiction treatment through telehealth. Collaborate with physicians to provide comprehensive care for patients with substance use disorders, ensuring a sup...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$120K - $160K *

Champion healthcare innovation by driving product adoption and relationships within key accounts. This role fosters collaboration across teams and builds trust with stakeholders to influence market be...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Lead the strategic design and management of comprehensive benefits programs, ensuring alignment with employee needs and company objectives. Drive innovation and compliance while enhancing employee eng...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Partner with us to drive transformative healthcare solutions by managing key accounts, fostering relationships, and ensuring measurable outcomes. Your expertise will enhance provider partnerships and...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$189K - $256K *

Join a global team to shape regulatory strategies in biotechnology, supporting product development and lifecycle management in Inflammation and Rare Diseases. Lead regulatory efforts, ensure complianc...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$235K - $329K *

Lead clinical pharmacology initiatives, overseeing drug development across infectious disease and oncology programs. Collaborate with cross-functional teams to drive strategic advancements and ensure...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.