Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$80K - $95K *
Champion excellence in rehabilitation services by leading a dedicated team, ensuring compliance with regulations, and enhancing patient care while achieving financial goals and fostering collaboration...
2 weeks ago
Senior Regulatory Affairs Specialist (Remote - United States)
$124K - $170K *
Champion regulatory strategies to accelerate product approvals and compliance. Lead a dynamic team in supporting innovative medical devices, ensuring alignment with global regulations while fostering...
1 week ago
21GRAMS- Associate Creative Director, Art
$160K - $180K *
Elevate healthcare creativity by leading innovative campaigns that transform client brands. Collaborate with teams to deliver impactful experiences across digital channels, leveraging insights and eme...
3 days ago
Director of US Oncology Portfolio Delivery
$169K - $282K *
Join a team that's redefining oncology clinical operations by leading a dynamic portfolio of studies. Drive excellence in delivery, manage complex projects, and mentor a talented team to ensure high-q...
Reposted 1 week ago
Director, Global Master Data Management & Data Governance
$150K - $258K *
Join a dynamic team driving Master Data Management strategies to enhance data governance and operational efficiency across global orthopedic initiatives. Lead cross-functional collaboration to ensure...
Yesterday
$69K - $100K *
Optimize coding operations by leading a team to ensure compliance, accuracy, and efficiency in billing processes. Collaborate with stakeholders to enhance documentation quality and coding integrity wh...
1 week ago
$81K - $122K *
Contribute to financial analysis and reporting, supporting strategic decision-making across departments. Collaborate with stakeholders to enhance budgeting, forecasting, and data management processes...
Today
$85K - $105K *
Join a team that's dedicated to delivering impactful medical communications. As a Senior Account Manager, you'll lead strategic projects for pharmaceutical clients, ensuring quality and timely executi...
1 week ago
Regional VP, Life Science Sales
$180K - $200K *
Unlock potential by driving sales strategies in the healthcare sector. Collaborate with C-Level executives, generate new opportunities, and enhance market presence while navigating complex enterprise...
3 weeks ago
Key Account Manager (IN, OH or NC)
$95K - $150K *
Drive success by building strong relationships with key customers, delivering strategic initiatives, and enhancing revenue growth. Collaborate across teams to identify opportunities and implement solu...
2 weeks ago
$110K - $130K *
Transform early phase clinical trials by leading design, execution, and oversight. Collaborate with cross-functional teams to ensure compliance and data integrity while managing project performance an...
4 weeks ago
Field Reimbursement Manager-Northeast
$185K - $230K *
Elevate patient access by managing reimbursement strategies for rare diseases. Collaborate with healthcare providers and internal teams to ensure compliance and support patient journeys through comple...
2 weeks ago
$85K - $97K *
Shape the future of healthcare by conducting clinical case reviews and enhancing product quality for an AI-driven clinical platform. Collaborate with care teams to ensure accurate alert functionality...
4 weeks ago
Associate Medical Director, Prostate Cancer Theranostics
$175K - $210K *
Drive the execution of a comprehensive medical affairs plan for prostate cancer theranostics, collaborating across functions to enhance strategy, launch readiness, and lifecycle planning while advanci...
2 weeks ago
$160K - $200K *
Elevate patient care by administering anesthesia and collaborating with healthcare teams. Develop pre-anesthetic plans, monitor patients, and ensure safety during procedures while communicating effect...
6 days ago
$160K - $200K *
Administer anesthesia and sedation for diverse procedures, develop pre-anesthetic plans, collaborate with healthcare teams, and monitor patient responses to ensure optimal care and safety throughout s...
6 days ago
$170K - $200K *
Unlock your potential in a dynamic anesthesia role, collaborating with a skilled team to deliver exceptional patient care. Enjoy a balanced schedule with generous time off while managing diverse surgi...
2 weeks ago
Professional (Senior) Sales Representative, Respiratory – Southern IL
$100K - $162K *
Drive sales success in the Southern IL territory by developing strategic business plans, conducting impactful presentations, and fostering strong relationships with healthcare professionals to achieve...
2 weeks ago
$75K - $125K *
Shape safety excellence by leading compliance initiatives in Process Safety Management. Collaborate with teams to implement and enhance safety programs, ensuring adherence to federal and state regulat...
Reposted today
Principal Scientist, Analytical Development
$170K - $190K *
Lead the charge in advancing analytical development strategies for small molecule drug substances and products, ensuring compliance and quality across the product lifecycle while collaborating with cr...
2 weeks ago
Associate Director Commercial Strategy and Planning
$146K - $178K *
Shape the future of biopharma by leading commercial strategy engagements, guiding clients through critical launch decisions, and delivering evidence-based recommendations to drive success in a dynamic...
1 week ago
$190K - $300K *
Engage with scientific leaders to exchange medical insights and support research initiatives. Drive scientific discussions, enhance understanding of therapeutic areas, and foster collaboration within...
2 weeks ago
$141K - $234K *
Transform healthcare analytics by leveraging advanced statistics and machine learning to uncover insights from complex datasets. Collaborate with experts to innovate and develop data-driven solutions...
Reposted 3 weeks ago
Senior Medical Science Liaison, South (Multiple Territories)
$190K - $220K *
Engage with key stakeholders as a Senior Medical Science Liaison, driving prelaunch and launch strategies. Build trusted relationships, deliver scientific insights, and influence adoption in a dynamic...
1 week ago
$110K - $130K *
Oversee the design and development of clinical databases while ensuring project timelines and quality standards are met. Collaborate across teams to provide technical support and mentor team members...
Reposted 1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.