Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$153K - $268K *

Join our team to provide expert clinical pharmacology insights, driving dose selection and study design for innovative therapies. Collaborate with cross-functional teams to translate complex data into...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Accelerate program implementation and stakeholder engagement in pharmaceutical market access. Oversee daily operations, client relations, and staff management while ensuring adherence to budgets and p...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $120K *

Join a dynamic team to drive customer activation and retention strategies across the prescription lifecycle. Collaborate cross-functionally to optimize customer journeys and deliver measurable growth...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$108K - $180K *

Transform pharmacy services by driving strategic initiatives and cross-functional projects. Collaborate with stakeholders, analyze outcomes, and mentor team members while shaping the future of pharmac...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Take ownership of IMP labeling processes, ensuring compliance with global regulations and quality standards while collaborating cross-functionally to support clinical trial timelines and enhance label...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$157K - $256K *

Shape strategic pricing and channel strategies for innovative therapies, ensuring patient access and affordability. Lead cross-functional initiatives, optimize distribution models, and drive market in...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$173K - $205K *

Shape the future of neurology by leading in vivo pharmacology studies, collaborating with cross-functional teams, and driving data-driven decisions for IND submissions in a dynamic biotech environment...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Drive impactful product launches and marketing strategies in healthcare, managing therapy lines from execution to analysis. Collaborate cross-functionally to enhance provider engagement and optimize p...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Drive growth and strengthen relationships across community clinics and AICs. Develop new business and expand partnerships while collaborating with key decision-makers in a complex healthcare market. T...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$378K - $420K *

Transform pharmacovigilance by leading a dedicated team, enhancing systems, and ensuring compliance across clinical and commercial products while driving safety strategy and governance...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $190K *

Unlock potential by leading analytical strategies for drug development, ensuring robust quality control throughout product lifecycle. Collaborate with partners to deliver exceptional insights that dri...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$153K - $268K *

Empower your career by leading bio sample operations across clinical studies. Oversee end-to-end processes, ensuring compliance and quality while collaborating with cross-functional teams and external...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform sales performance by leading and coaching a high-performing team, optimizing strategies, and driving innovative customer engagement in a dynamic biopharmaceutical environment...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $225K *

Unlock growth by leading strategic partnerships in the CDMO sector. Drive sales, nurture client relationships, and collaborate across teams to enhance market presence and customer satisfaction. Your e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$142K - $177K *

Lead legal initiatives by drafting documents, managing records, and providing counsel. Collaborate with executives to shape organizational direction while ensuring compliance and supporting continuous...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$177K - $283K *

Unlock potential by leading pharmacokinetic modeling for early-stage drug development. Collaborate with cross-functional teams to enhance drug absorption, distribution, metabolism, and excretion (ADME...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$193K - $241K *

Lead and oversee Medical Information teams, ensuring high-quality service delivery and compliance. Drive strategic initiatives, manage resources, and collaborate cross-functionally to enhance operatio...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$280K - $340K *

Transform regulatory strategy and operations across CMC and clinical activities, leading a high-performing team to ensure compliance and successful product approvals from development through post-appr...

United StatesRemote

3 weeks ago

  •   15+ years exp.  •   Information Technology

$106K - $167K *

Shape the future of physician relations by leading a dynamic team focused on enhancing patient acquisition and optimizing outreach strategies through data-driven insights and performance metrics...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$119K - $186K *

Lead the negotiation and administration of Branded & Specialty Rx contracts, ensuring alignment with business strategies and stakeholder interests. Collaborate with internal teams to optimize processe...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a dynamic team as a Senior Regional Pharmacy Consultant, driving client growth and retention through strategic pharmacy benefits expertise. Collaborate with market leaders and provide consultativ...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$200K - $270K *

Join a team that's redefining biostatistics in clinical development. You will lead statistical strategy across multiple therapeutic areas, ensuring excellence in design, analysis, and reporting while...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$119K - $186K *

Transform the future of supply chain technology by leading innovation initiatives, managing a structured evaluation process, and engaging stakeholders to drive measurable value and strategic alignment...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$193K - $308K *

Join a team that's redefining statistical leadership in clinical research. Drive innovative study designs, enhance drug development effectiveness, and influence critical decisions through data-driven...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$129K - $231K *

Reimagine drug discovery as you lead molecular pharmacology efforts in neuroscience. Collaborate across teams to develop strategies, interpret data, and advance innovative therapies for sleep-wake dis...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.