Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Advisor, Clinical Pharmacology
$153K - $268K *
Join our team to provide expert clinical pharmacology insights, driving dose selection and study design for innovative therapies. Collaborate with cross-functional teams to translate complex data into...
1 week ago
$90K - $110K *
Accelerate program implementation and stakeholder engagement in pharmaceutical market access. Oversee daily operations, client relations, and staff management while ensuring adherence to budgets and p...
Reposted 3 weeks ago
Senior Marketing Manager, Lifecycle & Growth
$90K - $120K *
Join a dynamic team to drive customer activation and retention strategies across the prescription lifecycle. Collaborate cross-functionally to optimize customer journeys and deliver measurable growth...
Reposted 6 days ago
$108K - $180K *
Transform pharmacy services by driving strategic initiatives and cross-functional projects. Collaborate with stakeholders, analyze outcomes, and mentor team members while shaping the future of pharmac...
4 weeks ago
Manager, Regulatory Affairs (Clinical Labeling)
$110K - $130K *
Take ownership of IMP labeling processes, ensuring compliance with global regulations and quality standards while collaborating cross-functionally to support clinical trial timelines and enhance label...
4 weeks ago
Associate Director, US Pricing, Contracting and Channel Strategy
$157K - $256K *
Shape strategic pricing and channel strategies for innovative therapies, ensuring patient access and affordability. Lead cross-functional initiatives, optimize distribution models, and drive market in...
3 days ago
Principal Scientist, In Vivo Pharmacology, Neurology
$173K - $205K *
Shape the future of neurology by leading in vivo pharmacology studies, collaborating with cross-functional teams, and driving data-driven decisions for IND submissions in a dynamic biotech environment...
4 weeks ago
$95K - $115K *
Drive impactful product launches and marketing strategies in healthcare, managing therapy lines from execution to analysis. Collaborate cross-functionally to enhance provider engagement and optimize p...
2 weeks ago
$160K - $200K *
Drive growth and strengthen relationships across community clinics and AICs. Develop new business and expand partnerships while collaborating with key decision-makers in a complex healthcare market. T...
2 weeks ago
$378K - $420K *
Transform pharmacovigilance by leading a dedicated team, enhancing systems, and ensuring compliance across clinical and commercial products while driving safety strategy and governance...
4 weeks ago
Principal Scientist, CMC Analytical
$150K - $190K *
Unlock potential by leading analytical strategies for drug development, ensuring robust quality control throughout product lifecycle. Collaborate with partners to deliver exceptional insights that dri...
Reposted 3 weeks ago
Advisor, Bio Sample Operations - DMPK
$153K - $268K *
Empower your career by leading bio sample operations across clinical studies. Oversee end-to-end processes, ensuring compliance and quality while collaborating with cross-functional teams and external...
5 days ago
Regional Business Manager - Midwest Region
$110K - $130K *
Transform sales performance by leading and coaching a high-performing team, optimizing strategies, and driving innovative customer engagement in a dynamic biopharmaceutical environment...
3 weeks ago
Senior Director Business Development-West Coast
$200K - $225K *
Unlock growth by leading strategic partnerships in the CDMO sector. Drive sales, nurture client relationships, and collaborate across teams to enhance market presence and customer satisfaction. Your e...
1 week ago
Sr. Staff Attorney (Regulatory)
$142K - $177K *
Lead legal initiatives by drafting documents, managing records, and providing counsel. Collaborate with executives to shape organizational direction while ensuring compliance and supporting continuous...
Today
Director, Translational Pharmacokinetics - DMPK
$177K - $283K *
Unlock potential by leading pharmacokinetic modeling for early-stage drug development. Collaborate with cross-functional teams to enhance drug absorption, distribution, metabolism, and excretion (ADME...
1 week ago
$193K - $241K *
Lead and oversee Medical Information teams, ensuring high-quality service delivery and compliance. Drive strategic initiatives, manage resources, and collaborate cross-functionally to enhance operatio...
6 days ago
Vice President, Regulatory Affairs
$280K - $340K *
Transform regulatory strategy and operations across CMC and clinical activities, leading a high-performing team to ensure compliance and successful product approvals from development through post-appr...
3 weeks ago
Physician Relations Team Manager
$106K - $167K *
Shape the future of physician relations by leading a dynamic team focused on enhancing patient acquisition and optimizing outreach strategies through data-driven insights and performance metrics...
Yesterday
Senior Manager, Brand & Specialty Rx Contracts
$119K - $186K *
Lead the negotiation and administration of Branded & Specialty Rx contracts, ensuring alignment with business strategies and stakeholder interests. Collaborate with internal teams to optimize processe...
1 week ago
Senior Regional Pharmacy Consultant
$95K - $115K *
Join a dynamic team as a Senior Regional Pharmacy Consultant, driving client growth and retention through strategic pharmacy benefits expertise. Collaborate with market leaders and provide consultativ...
1 week ago
Biostatistics Director, Oncology Biosimilars- US Remote
$200K - $270K *
Join a team that's redefining biostatistics in clinical development. You will lead statistical strategy across multiple therapeutic areas, ensuring excellence in design, analysis, and reporting while...
2 weeks ago
Director, Technology Innovation COE
$119K - $186K *
Transform the future of supply chain technology by leading innovation initiatives, managing a structured evaluation process, and engaging stakeholders to drive measurable value and strategic alignment...
2 weeks ago
Director - Statistics - Lilly Regenerative Medicines
$193K - $308K *
Join a team that's redefining statistical leadership in clinical research. Drive innovative study designs, enhance drug development effectiveness, and influence critical decisions through data-driven...
1 week ago
Sr. Advisor, Molecular Pharmacology - Neuroscience
$129K - $231K *
Reimagine drug discovery as you lead molecular pharmacology efforts in neuroscience. Collaborate across teams to develop strategies, interpret data, and advance innovative therapies for sleep-wake dis...
Reposted 3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.