Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$90K - $120K *

Transform patient care by delivering precise teleradiology interpretations across various shifts, utilizing AI tools to enhance workflow and maintain high-quality standards while collaborating with he...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $105K *

Join a specialized team to evaluate biological research, ensuring safety against misuse. Utilize your expertise to distinguish legitimate science from potential threats, contributing to AI safety and...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$110K - $172K *

Lead the charge in revolutionizing the data center market by driving new business. Utilize your technical expertise and commercial insight to develop strategies that enhance revenue and establish stro...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$147K - $200K *

Drive strategic category management initiatives for Full-Service CRO, collaborating across teams to optimize procurement processes, reduce costs, and enhance supplier performance while ensuring compli...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$65K - $109K *

Partner with us to foster strategic relationships, optimize account performance, and drive engagement with key stakeholders, leveraging your knowledge of healthcare technology to deliver impactful sol...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock potential by leading compliance audits, ensuring accurate coding and documentation in anesthesia. Collaborate with teams to mitigate risks, deliver training, and maintain regulatory standards w...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$230K - $345K *

Shape the future of late-stage oncology clinical trials by leading strategic initiatives, ensuring operational excellence, and fostering cross-functional partnerships to drive successful trial executi...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$109K - $136K *

Drive accurate, evidence-based clinical claims while collaborating with Marketing, Legal, and Clinical teams. Build and manage the claims framework and evidence library to support bold, compliant mark...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Contribute to impactful consulting services in government pricing, leveraging your expertise to guide clients through compliance, data analysis, and strategic initiatives while leading a collaborative...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join us to minimize access barriers for patients and providers, executing market access plans across multiple states. Collaborate with healthcare professionals to resolve reimbursement issues and enha...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$232K - $348K *

Lead the charge in oncology pharmacology, managing scientific teams to drive drug discovery from early stages through regulatory approval while ensuring alignment across cross-functional teams...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$235K - $270K *

Lead strategic access initiatives and relationships with key stakeholders in managed markets, ensuring alignment and execution of the access strategy for a growing portfolio of therapies. Drive contra...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $155K *

Empower patients by delivering compassionate, patient-centered palliative care through virtual consultations. Collaborate with a dynamic team to enhance quality of life for members with complex needs...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Join a team that's shaping high-impact strategies and narratives for enterprise growth. Collaborate with senior leaders to craft compelling pitches and support organic initiatives, driving success acr...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Drive the translational strategy for immunology therapies, focusing on biomarker development and clinical pharmacology. Collaborate cross-functionally to advance pipeline assets and support regulatory...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$128K - $176K *

Take ownership of scientific partnerships with healthcare professionals, driving evidence generation and strategic initiatives. Collaborate across teams to enhance patient care and strengthen scientif...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$225K - $250K *

Elevate your career by leading payer sales strategy and team development, driving new business opportunities in healthcare technology. Collaborate with executives to enhance performance and deliver im...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$150K - $230K *

Unlock your potential by driving oncology product success through strategic relationships and innovative solutions. Collaborate with key stakeholders to enhance patient access and exceed performance g...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$90K - $111K *

Optimize customer interactions by leading design and prototyping efforts. Collaborate with stakeholders to enhance experiences, drive strategic planning, and implement innovative solutions that align...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $215K *

Lead the charge in driving regional sales success through strategic execution, team leadership, and cross-functional collaboration. Foster strong customer relationships and ensure alignment with corpo...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Champion clinical services initiatives, driving strategic content development and mentoring teams to enhance market access and client success. Lead projects, ensure compliance with standards, and reso...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$217K - $294K *

Innovate the U.S. Cardiovascular & Metabolic Medical strategy, leading evidence generation and stakeholder engagement for chronic weight management. Collaborate cross-functionally to ensure launch rea...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$123K - $168K *

Explore the potential of Neurocrine products by managing key accounts, driving sales growth, and fostering relationships with healthcare professionals. Collaborate cross-functionally to enhance produc...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$195K - $217K *

Drive client success by leading strategic initiatives and fostering strong relationships in healthcare technology. Leverage deep domain expertise to enhance outcomes and ensure effective use of soluti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.