Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$109K - $179K *

Join a team that's shaping regulatory strategies for advertising and promotion. Leverage your expertise to ensure compliance while collaborating with cross-functional teams to drive impactful product...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$72K - $192K *

Join a team that's dedicated to enhancing client relationships in healthcare. As a trusted advisor, you'll guide clients through workflows, drive feature adoption, and develop strategic plans to maxim...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$215K - $235K *

Advance drug substance development and drive clinical readiness projects by leading process chemistry initiatives, collaborating with cross-functional teams, and ensuring regulatory compliance for suc...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$105K - $120K *

Engage with public health labs to enhance customer satisfaction and drive sales. Collaborate with cross-functional teams to execute market strategies and foster relationships with key opinion leaders...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Develop high-quality, scientifically accurate content for medical affairs and promotional education. Collaborate with teams to ensure clarity and compliance while translating complex data into engagin...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Transform the beverage and dessert ingredient landscape by driving sales growth, expanding market presence, and fostering strong customer relationships. Collaborate with cross-functional teams to deli...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$162K - $203K *

Transform your career by engaging with key opinion leaders in Urology and Women's Health. Leverage your scientific expertise to drive medical strategies and foster relationships that enhance product u...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Shape the future of healthcare by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$190K - $285K *

Advance regulatory strategies for global CMC submissions, managing cross-functional collaboration and internal processes to meet compliance with health authority standards, while leveraging strong com...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform your career by driving sales growth and client relationships in oncology. Leverage your expertise in radiopharmaceuticals to identify opportunities, manage accounts, and deliver exceptional...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$175K - $250K *

Join a team that's optimizing medical cost management and driving financial performance across Commercial lines. Leverage your expertise in healthcare economics to influence strategic contracting and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Pioneer innovative strategies as a Medical Science Liaison, engaging with key opinion leaders and driving platform adoption. Collaborate across teams to translate clinical needs into actionable insigh...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a team that's driving financial strategy and operations, leading forecasting, reporting, and analysis to support a fast-growing organization with impactful decision-making and collaboration acros...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Drive impactful oncology product promotion by building strong relationships with key stakeholders, exceeding performance goals, and ensuring patient access to innovative therapies within your territor...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$128K - $176K *

Drive clinical excellence and strategic medical affairs to enhance patient care through innovative product development, evidence generation, and cross-functional collaboration, ensuring compliance and...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Grow your career with a dynamic role that drives oncology product success, builds key relationships, and enhances patient access through strategic engagement and innovative solutions in a competitive...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Empower your career by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and enhance patient access while col...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$190K - $225K *

Elevate your career by engaging with key opinion leaders and healthcare professionals. This role focuses on scientific collaboration and strategic partnerships, driving impactful medical insights with...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Elevate commercial performance by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring complian...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$174K - $374K *

Inspire health and wellness by conducting in-home evaluations, building relationships, and bridging care gaps. Travel extensively to provide personalized health assessments, ensuring comprehensive sup...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Drive clinical excellence by providing medical expertise across therapeutic areas, ensuring safety and integrity in clinical trials. Collaborate with project teams and senior management to enhance cli...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $172K *

Elevate your career by driving growth in national health plan accounts. Leverage your expertise to build relationships, negotiate complex deals, and exceed revenue targets while collaborating with cro...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $192K *

Deliver exceptional sales and support within the healthcare sector, building productive relationships with providers while driving product adoption and ensuring patient access to innovative therapies...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$167K - $300K *

Unlock your potential by leading regional oncology thought leader engagement and advocacy strategies. Collaborate with cross-functional teams to shape brand strategy and launch planning for innovative...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.