Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Director, Medical - Clinical Research Scientist
$177K - $338K *
Help us advance women's health through innovative clinical trial strategies, where you will conduct, support, and report on global studies for cutting-edge compounds, ensuring adherence to regulatory...
Reposted 1 week ago
Manager, Applications, Epic Orders
$165K - $264K *
Pioneer cross-functional collaboration to manage IS projects, ensuring successful implementation and support of applications, upgrades, and integrations while overseeing budgets and resources across S...
2 days ago
Territory Sales Manager - Specialty (Boston N, MA)
$125K - $157K *
Advance market share and sales objectives by building strong relationships and leveraging clinical expertise. Collaborate with teams to analyze trends and drive strategic initiatives in a dynamic heal...
2 weeks ago
Sr. Manager, Provider Data Operations & Attribution Integrity
$67K - $199K *
Empower operational excellence by leading provider data governance and attribution processes. Collaborate across departments to ensure data integrity, enhance reporting accuracy, and drive continuous...
1 week ago
Account Specialist, Gainesville-Daytona Beach, FL
$160K - $192K *
Accelerate commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to optimize patient access and support innovative therapies in a dy...
1 week ago
$122K - $203K *
Empower teams by leading data governance initiatives, enhancing data quality, and fostering collaboration across business domains. Drive operational excellence and ensure compliance while developing a...
1 week ago
Account Specialist (Madison, WI)
$160K - $192K *
Join a dynamic team to drive commercial performance and enhance patient access through strong relationships with healthcare providers, executing strategic business plans in a pivotal role focused on i...
1 week ago
Senior Oncology Account Manager, Indianapolis
$150K - $230K *
Drive impactful oncology solutions by building relationships with key stakeholders. Leverage your expertise to promote innovative products, exceed performance goals, and enhance patient access while n...
1 week ago
Director, Field Effectiveness, Rare Disease and Oncology
$193K - $262K *
Champion the sales force's success by leading a dynamic team focused on optimizing field effectiveness and operational efficiency, driving excellence in performance and insights...
1 month ago
Senior Oncology Account Manager, New Orleans
$150K - $230K *
Champion the promotion of oncology products, building strong relationships with key stakeholders. Drive performance goals, manage territory effectively, and ensure patient access to treatments while e...
1 week ago
Case Manager, Registered Nurse (Oncology experience required)
$54K - $155K *
Lead the charge in telephonic case management, collaborating with patients and care teams to support quality healthcare delivery. Use clinical expertise to assess needs, implement strategies, and ensu...
Reposted yesterday
Account Manager, Molecular Diagnostics, QIAstat (Midwest)
$100K - $120K *
Advance healthcare solutions by driving sales of innovative diagnostic instruments. Engage with key stakeholders to promote QIAstat-Dx systems, ensuring successful adoption and customer satisfaction t...
3 days ago
Manager, Policy and Compliance, Certification
$95K - $115K *
Lead the charge in overseeing compliance frameworks and regulatory trends, ensuring the certification team adapts to changes. Collaborate cross-functionally to integrate policy expertise and support c...
3 weeks ago
Advisor II, Health Supply Chain, Continuity of Integrated Health Services (CIHS) Project
$80K - $95K *
Empower global health initiatives by enhancing supply chain systems across multiple countries. Collaborate with teams to ensure compliance, efficiency, and capacity building in logistics and procureme...
2 weeks ago
Clinical Oversight Manager (COM) - USA
$110K - $130K *
Accelerate progress at the forefront of clinical research by ensuring effective oversight and management of clinical studies. Collaborate with teams to uphold quality standards and drive successful st...
2 days ago
Sales Representative, P&HS NA, Great Lakes
$110K - $125K *
Elevate the paper manufacturing sector by driving sales and fostering relationships with key accounts. Leverage your expertise to identify and implement effective chemical applications that enhance ef...
Reposted 2 weeks ago
Senior Oncology Account Manager, San Jose
$150K - $230K *
Engage with key stakeholders to promote oncology products, build relationships, and drive brand value. Utilize market insights to develop strategic plans, ensuring patient access and exceeding perform...
1 week ago
Sr. Director, Industry and Payor Strategy
$174K - $217K *
Drive strategic leadership in industry partnerships and payor strategy, enhancing market access and competitive positioning. Lead a high-performing team to execute a multiyear plan that fosters sustai...
3 days ago
$80K - $95K *
Support project management by coordinating study documentation, mentoring team members, and ensuring compliance. Leverage expertise in clinical research to enhance study start-up and execution, while...
1 week ago
Senior Project Manager, Promotional Medical Education
$90K - $100K *
Accelerate progress at a dynamic agency by leading complex client campaigns. Manage project scope, timelines, and budgets while collaborating with cross-functional teams to deliver high-quality result...
Reposted 1 week ago
Senior Regional Sales Consultant
$95K - $115K *
Transform healthcare engagement by building relationships with HCPs through digital interactions and telephone conversations, promoting products, and achieving sales goals while ensuring compliance wi...
2 weeks ago
Senior Oncology Account Manager, Minneapolis
$150K - $230K *
Champion innovative oncology solutions by building strong relationships with key stakeholders. Drive product success through strategic engagement and effective territory management, ensuring timely ac...
1 week ago
$160K - $170K *
Join a team that's redefining production excellence by leading end-to-end photo and video shoots. You'll manage budgets, build partnerships, and create efficient workflows while ensuring brand integri...
2 weeks ago
Professional (Senior) Sales Representative, Pain - Little Rock, AR
$100K - $162K *
Optimize sales performance by developing strategic business plans, driving quarterly goals, and building strong relationships with healthcare professionals, while ensuring compliance and continuous pr...
Reposted 1 week ago
Senior Manager, REMS Operations
$141K - $212K *
Deliver strategic oversight and operational management for FDA-mandated REMS programs, ensuring compliance, governance, and collaboration across teams and vendors to enhance program effectiveness and...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.