Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$150K - $200K *
Elevate your career by leading HCP engagement and clinical marketing initiatives. Drive strategic insights and educational content for the HSCT portfolio, fostering impactful connections and enhancing...
Yesterday
Account Manager, Dietary Supplements (California, Arizona, New Mexico)
$120K - $145K *
Champion sales growth in the dietary supplements sector by managing client relationships, analyzing market trends, and driving innovative solutions to meet profitability targets and enhance brand posi...
6 days ago
Executive Director, Health Economics & Outcomes Research (HEOR)
$246K - $332K *
Shape the future of health economics and outcomes research by leading strategic initiatives across the nephrology portfolio, ensuring high-quality evidence generation and collaboration with cross-func...
1 week ago
Transportation Consultant - Final Mile
$68K - $97K *
Lead operational stability and process standardization for transportation across multiple facilities. Collaborate with planners and logistics partners to enhance delivery performance and resolve disru...
Yesterday
Account Specialist (Palm Springs, CA)
$160K - $192K *
Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...
1 week ago
Senior Process Engineer, Drug Substance
$110K - $125K *
Join a dynamic team to oversee process validation and support for small molecule API manufacturing, ensuring compliance and quality in collaboration with CMOs while driving continuous improvement and...
2 weeks ago
Director, Labeling and Nutrition Compliance
$110K - $130K *
Lead the charge in labeling and nutrition compliance, overseeing the source-to-label process, ensuring regulatory adherence, and managing cross-functional deliverables to maintain product integrity an...
1 week ago
Senior Oncology Account Specialist Tivdak Seattle WA
$108K - $250K *
Drive impactful oncology solutions by promoting a diverse product portfolio, educating healthcare professionals, and enhancing patient care through strategic account management and relationship buildi...
Reposted 3 days ago
$210K - $260K *
Join a fast-paced team of medical professionals to evaluate and enhance service appropriateness through evidence-based guidelines, impacting quality patient outcomes across multiple specialties while...
Reposted 3 weeks ago
$205K - $240K *
Shape the future of oncology as a Senior Medical Science Liaison, creating impactful scientific engagement within hematology and oncology that enhances patient care. Collaborate with KOLs and cross-fu...
Reposted 1 week ago
$145K - $165K *
Drive your career by owning the end-to-end data platform, designing and maintaining scalable pipelines and infrastructure. Collaborate with analytics teams to ensure data quality and governance while...
1 week ago
Senior Advisor, Clinical Science (remote)
$168K - $283K *
Lead the charge in advancing early-stage clinical trials for innovative Orexin-targeted therapies. Collaborate cross-functionally to shape scientific strategy, drive execution, and ensure high-quality...
2 weeks ago
Senior Advisor, Clinical Science (remote)
$153K - $268K *
Transform clinical science in late-stage trials for innovative sleep/wake therapies. Collaborate cross-functionally to ensure compliance, drive recruitment, and deliver high-quality results while shap...
2 weeks ago
Senior Oncology Account Manager, Denver
$150K - $230K *
Drive impactful oncology solutions by building strong relationships with key stakeholders, promoting innovative products, and exceeding performance goals in a dynamic biopharma environment. Your exper...
1 week ago
$67K - $100K *
Drive category sourcing strategies and supplier relationships to optimize procurement processes, ensuring alignment with organizational standards and delivering value across assigned categories while...
2 weeks ago
GEO Strategy & Operations Senior Manager, RDBU & Global
$143K - $194K *
Advance your career by driving GEO strategy and operations, coordinating cross-functional efforts, and optimizing digital marketing initiatives for a global brand portfolio in a dynamic and collaborat...
Reposted today
$101K - $146K *
Unlock potential by leading payer contract negotiations to enhance relationships, optimize revenue, and ensure compliance with regulations, all while aligning with strategic priorities of the health s...
3 weeks ago
Associate Director, Social Media
$90K - $115K *
Elevate your career by leading innovative social media programs that connect healthcare clients with their audiences. Drive strategic content development and manage cross-functional teams to ensure im...
Reposted 1 week ago
South Central, Key Account Manager, Cattle
$80K - $95K *
Unlock potential by driving sales growth and fostering customer relationships in the cattle healthcare sector. Collaborate with a dynamic team to achieve strategic objectives and enhance brand presenc...
2 weeks ago
Director - Medical - Clinical Research Physician
$201K - $393K *
Lead the development and execution of global clinical trials for women's health compounds, collaborating with cross-functional teams to shape clinical strategies and ensure compliance with regulatory...
Reposted yesterday
Assistant Professor, Physician Assistant
$110K - $159K *
Join us to foster an innovative educational environment, providing leadership and mentorship while enhancing curriculum and teaching methodologies to ensure student success and engagement in learning...
3 weeks ago
Senior Regulatory Submissions Lead
$145K *
Drive innovation and transform lives by leading regulatory strategies and submissions for clinical trials globally. Act as a key liaison for project teams to ensure compliance, operational excellence...
Reposted 1 week ago
Associate Director, Study Operations Manager - Nonclinical Toxicology
$129K - $231K *
Elevate nonclinical toxicology operations by managing study execution, ensuring compliance, and fostering collaboration across teams to advance innovative therapies for sleep-wake disorders. Drive acc...
2 days ago
Director of Procurement (Remote)
$110K - $130K *
Shape the future of procurement by leading strategic sourcing initiatives, enhancing vendor relationships, and driving financial transparency. Collaborate across teams to streamline processes and leve...
3 weeks ago
$262K - $404K *
Optimize patient care and operational leadership as you manage Anesthesia APP teams, ensure regulatory compliance, and build strong client relationships while driving growth in practices and enhancing...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.