Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$150K - $175K *

Transform your career by partnering with business teams in a dynamic legal environment. Leverage your commercial instincts and regulatory expertise to make an immediate impact across two brands in a f...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Food & Beverages

$100K - $139K *

Drive strategic growth by managing client relationships and leading account teams. Oversee financial management and ensure team development while fostering a collaborative environment to enhance agenc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive customer success by managing key accounts in cattle genomics. Collaborate with cross-functional teams to enhance service delivery, support genomic solutions, and ensure high-quality customer exp...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$140K - $190K *

Join a team that's dedicated to driving revenue growth in the Pulmonary sector by engaging healthcare professionals and implementing strategic initiatives to enhance product utilization and foster str...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$222K - $255K *

Lead the biostatistical strategies that support impactful medical communication efforts. Collaborate cross-functionally to provide scientific expertise, develop publication strategies, and ensure meth...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$108K - $196K *

Shape the future of healthcare by managing client relationships and optimizing clinical programs. Collaborate with teams to drive client success and ensure alignment with company goals, leveraging dat...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $95K *

Transform client relationships by leading strategic projects, ensuring quality and alignment across teams. Collaborate with stakeholders to drive success and meet client expectations while fostering g...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Pioneer innovative oncology solutions by building strong relationships with key stakeholders, driving product adoption, and exceeding performance goals in a dynamic biopharma environment focused on pa...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$163K - $297K *

Join a dynamic team to shape the future of digital consumer experiences in LATAM. Lead product strategy and execution for innovative e-commerce solutions, driving customer satisfaction and loyalty whi...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Lead the technical direction for inhaled dry powder products, ensuring product performance and manufacturability while collaborating with cross-functional teams to navigate development and regulatory...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$157K - $256K *

Champion strategic engagements with oncology thought leaders to enhance insights and drive initiatives for our Solid Tumor portfolio, focusing on collaboration across teams and executing regional stra...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $190K *

Champion quality assurance excellence in GMP for drug substance and products, overseeing compliance and methodologies. Collaborate to ensure regulatory adherence while maintaining operational efficien...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Information Technology

$106K - $159K *

Transform regulatory strategies by providing CMC expertise to support product development and compliance in a dynamic pharmaceutical environment, ensuring quality and adherence to global standards thr...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Drive your career with a pivotal role in CMC regulatory affairs, ensuring compliance for biologics and small molecules. Collaborate across teams to prepare high-quality submissions and strategies, imp...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $135K *

Empower clinical research excellence by managing projects that ensure compliance with regulatory requirements and drive successful study delivery from initiation to closeout. Collaborate with interdis...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $90K *

Drive innovative advertising strategies by transforming customer insights and performance data into compelling creative content. Collaborate with cross-functional teams to enhance product visibility a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$160K - $192K *

Transform commercial performance by engaging healthcare providers, driving product adoption, and collaborating with cross-functional teams to ensure patient access to innovative therapies across a def...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$127K *

Contribute to transforming virtual primary care by delivering exceptional patient assessments, treatment plans, and ongoing support. Collaborate with healthcare teams while leveraging technology to en...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$167K - $300K *

Lead the charge in oncology marketing by developing KOL engagement strategies and insights for individualized therapies. Collaborate cross-functionally to drive brand strategy and launch planning, ens...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$240K - $269K *

Advance your career by leading national account strategies in oncology, fostering relationships with health plans and PBMs. Drive coverage, reimbursement, and adoption initiatives while collaborating...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$114K - $154K *

Transform supply chain operations by managing SAP systems and processes, ensuring seamless logistics and distribution support. Drive efficiency and issue resolution across Commercial and Clinical Supp...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Join a team that's shaping evidence strategies and insights in health economics and outcomes research. Lead client engagements, oversee analytics, and drive impactful decision-making in biopharma and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Shape the future of compassionate care by leading a multidisciplinary team to enhance the quality of life for patients in their final stages, ensuring comfort, dignity, and emotional support through p...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in case management by overseeing complex pharmacy reimbursement processes, ensuring timely completion of cases, and advocating for patients while collaborating with healthcare provider...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$129K - $174K *

Lead a dynamic programming team to enhance data analysis strategies, ensuring high-quality biomedical data presentation while driving efficiency and innovation in a collaborative environment focused o...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.