Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$117K - $160K *
Champion profitable growth by managing E&S commercial property and casualty underwriting. Leverage strong technical skills and relationships to assess risks, deliver competitive quotes, and optimize p...
1 week ago
VP, Law Firm Professional Services
$250K - $300K *
Shape the future of AI-powered implementations by leading a dynamic team, redefining best practices, and building a robust partner ecosystem to enhance client success and drive growth in a fast-paced...
3 days ago
$83K - $104K *
Lead the charge in managing complex client programs, driving operational excellence and strategic direction while fostering strong stakeholder relationships and ensuring exceptional service delivery...
Today
Manager of Client Management, CORE East Segment - Cigna Global Health Benefits (GHB) - Remote
$110K - $130K *
Transform client relationships by leading a dynamic team to achieve financial growth and enhance client experiences across a diverse portfolio. Drive strategic initiatives and foster collaboration to...
6 days ago
Healthcare Program & Project Manager (Remote)
$80K - $95K *
Transform healthcare initiatives by leading projects from inception to completion. Coordinate teams, manage timelines, and ensure clear communication to drive organizational priorities and deliver mea...
Yesterday
Liability Claims Team Lead | Dedicated Client | East Coast States
$95K - $104K *
Lead a dynamic team to adjudicate complex liability claims, driving innovative solutions for diverse clients. Collaborate with experts to enhance processes and ensure exceptional service in a rapidly...
1 week ago
Regional Sales Director - St. Louis
$180K - $215K *
Tackle the challenge of launching a groundbreaking product by leading a high-performing sales team, driving regional execution, and fostering key customer relationships in a dynamic, fast-paced enviro...
1 week ago
Senior Computer System Validation Specialist
$105K - $130K *
Optimize validation strategies and ensure compliance for GxP-regulated systems. Lead risk assessments, mentor junior team members, and oversee quality assurance activities throughout the system lifecy...
Reposted 1 week ago
Sr. Director, eDiscovery Technology & AI
$156K - $195K *
Champion the global eDiscovery Technology practice, leading a diverse team to innovate AI-assisted workflows, ensuring defensibility and quality across jurisdictions while driving growth and operation...
1 week ago
Account Specialist (Norfolk, VA)
$160K - $192K *
Grow your career by engaging healthcare providers and driving commercial success. Collaborate with cross-functional teams to support product launches and enhance patient access to innovative therapies...
1 week ago
$156K - $255K *
Partner with us to drive revenue growth by engaging in sales pursuits, demonstrating business value, and advising teams on value management principles to ensure successful customer outcomes and impact...
2 weeks ago
$108K - $196K *
Shape the future of healthcare by managing client relationships and optimizing clinical programs. Collaborate with teams to drive client success and ensure alignment with company goals, leveraging dat...
1 month ago
$100K - $120K *
Drive strategic oversight of enterprise-wide RAC audit activities, ensuring compliance and operational excellence. Collaborate with leadership to enhance audit processes, minimize financial risk, and...
1 week ago
Senior Change Orders Associate
$83K - $99K *
Optimize budget development for clinical change orders, collaborating across departments. Drive operational success by managing the budget lifecycle, ensuring accuracy, and resolving issues to support...
Reposted 4 weeks ago
$80K - $95K *
Drive comprehensive legal support across diverse business functions, managing contracts, insurance, and litigation. Collaborate with cross-functional teams to ensure compliance and facilitate growth i...
2 weeks ago
Business Development Manager - Healthcare
$100K - $120K *
Join a team that's transforming healthcare by driving sales of innovative water purification systems. Leverage your expertise to build relationships and ensure compliance, enhancing patient safety acr...
3 weeks ago
Senior Director, IT & Enterprise Applications - Remote
$160K - $200K *
Lead IT's AI-first transformation by driving vision, coordinating cross-functional initiatives, and ensuring platform uptime while empowering teams to adopt AI tools effectively across the organizatio...
Reposted 6 days ago
Associate Director, CMC Operations
$155K - $190K *
Manage the planning and execution of CMC operations across multiple development programs, ensuring alignment with regulatory milestones and efficient collaboration with cross-functional teams and CDMO...
1 week ago
Clinical Development Associate
$92K - $120K *
Elevate clinical trial execution by supporting the development team in data review, safety tracking, and cross-functional collaboration to advance innovative clinical programs in ophthalmology...
6 days ago
$184K - $254K *
Shape the future of corporate strategy by leading cross-functional teams to develop enterprise-wide strategic plans, drive growth initiatives, and influence senior leadership decisions through data-dr...
2 days ago
Executive Director, Manufacturing
$175K - $210K *
Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...
Yesterday
Lead Analyst, People Analytics
$113K - $188K *
Optimize security administration and reporting processes while collaborating with cross-functional teams to enhance data insights and compliance metrics. Drive effective use of Workday tools and ensur...
Yesterday
Senior Systems Specialist, FP&A
$116K - $157K *
Grow your career with our FP&A Systems team, designing innovative EPM solutions and enhancing financial planning processes. Collaborate with various stakeholders to optimize efficiency and ensure data...
Reposted 3 weeks ago
Associate Director, Regulatory Science
$177K - $221K *
Champion regulatory excellence by leading cross-functional teams, ensuring compliance, and driving successful oncology drug development through strategic planning and expert guidance...
1 week ago
Vice President, Regulatory Affairs
$280K - $340K *
Transform regulatory strategy and operations across CMC and clinical activities, leading a high-performing team to ensure compliance and successful product approvals from development through post-appr...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.