Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Associate Director, Client Media Solutions
$95K - $120K *
Accelerate progress at the intersection of media and healthcare by leading integrated planning and strategy for pharmaceutical clients. Drive impactful engagement initiatives while mentoring a talente...
1 week ago
Sr. Solution Architect, Integrations (MANTL)
$96K - $120K *
Partner with cross-functional teams to drive successful integrations, ensuring best practices and client satisfaction. Become the internal expert on data management while leading technical relationshi...
3 weeks ago
$135K - $165K *
Pioneer operational excellence in Design leadership, managing workflows, prioritizing projects, and developing talent. Collaborate cross-functionally to enhance Design integration in AI-driven product...
1 week ago
$80K - $95K *
Join a team that's dedicated to enhancing client experiences through exceptional facility management. Oversee multiple locations, collaborate on strategic initiatives, and ensure a welcoming atmospher...
Today
Analyst, Financial Planning & Analysis
$108K - $148K *
Join us as a Senior FP&A Analyst to drive financial planning, reporting, and forecasting. Collaborate across teams to optimize spending and enhance our financial systems, leveraging AI for insights th...
2 weeks ago
Principal Database Analyst (Ellsworth AFB)
$84K - $127K *
Manage and enhance database operations, ensuring security and performance. Collaborate with teams to develop innovative solutions and maintain integrity controls while contributing to policy formulati...
1 week ago
Account Executive - Healthcare (Northeast)
$125K - $150K *
Champion growth by building strategic relationships and driving sales in the Healthcare sector. Leverage AI solutions to enhance customer engagement and achieve revenue targets while collaborating wit...
2 weeks ago
$100K - $185K *
Elevate the legal landscape by leveraging AI to transform workflows. Collaborate with law firms to design and implement innovative solutions, ensuring successful adoption of advanced legal technologie...
1 week ago
Sr Enterprise Account Executive - East U.S
$300K - $350K *
Join a dynamic team as you lead enterprise sales cycles, driving growth and establishing a strong presence in Conversational AI. Your expertise will influence strategy and secure high-impact deals wit...
2 weeks ago
Associate Underwriter, Northeast
$70K - $100K *
Join a dynamic team to drive profitable business through strategic underwriting and broker partnerships. Leverage your expertise to enhance client relationships and contribute to innovative solutions...
3 days ago
$110K - $130K *
Lead cross-functional project execution in Medication Contracting, translating strategic priorities into actionable plans. Drive improvements, manage risks, and enhance collaboration across teams to e...
Yesterday
Nurse Practitioner or Physician Assistant | Neurology | Inpatient
$90K - $110K *
Take ownership of patient care by assessing, diagnosing, and treating individuals. Collaborate with physicians to develop care plans, educate patients, and ensure quality health services in a supporti...
1 week ago
$71K - $106K *
Join a team that crafts compelling pitches and proposals for client-focused opportunities. Collaborate across business units in a dynamic environment, driving innovative solutions and business develop...
Reposted 2 weeks ago
Clinical Expert Advisor - Remote, US
$162K - $224K *
Transform healthcare operations by leveraging your expertise to drive efficiency and improve outcomes. Engage with clients to analyze needs, manage projects, and lead teams in delivering sustainable p...
Yesterday
Director, Engineering (AI Patient Engagement Platform)
$180K - $230K *
Join a dynamic team as you lead engineering efforts to develop an AI Patient Engagement Agent, transforming clinical trials by automating patient interactions and enhancing operational efficiency for...
2 weeks ago
Senior Manager, Patient Services Promotions
$138K - $183K *
Lead the development and execution of patient support strategies to enhance access and engagement for oncology therapies, collaborating cross-functionally to optimize promotional initiatives and drive...
1 week ago
Senior Director, National Field Excellence
$217K - $271K *
Launch your career by owning the national Field Excellence model, managing operations for a groundbreaking oncology therapy. Collaborate with sales leaders to enhance prescriber access and streamline...
1 week ago
HIM Outpatient Coding Supervisor
$68K - $113K *
Lead the charge in optimizing coding accuracy and compliance by analyzing complex patient care documentation, providing expert guidance, and enhancing coder education to ensure adherence to ethical st...
3 weeks ago
$117K - $160K *
Champion profitable growth by managing E&S commercial property and casualty underwriting. Leverage strong technical skills and relationships to assess risks, deliver competitive quotes, and optimize p...
1 week ago
VP, Law Firm Professional Services
$250K - $300K *
Shape the future of AI-powered implementations by leading a dynamic team, redefining best practices, and building a robust partner ecosystem to enhance client success and drive growth in a fast-paced...
3 days ago
$83K - $104K *
Lead the charge in managing complex client programs, driving operational excellence and strategic direction while fostering strong stakeholder relationships and ensuring exceptional service delivery...
Today
Manager of Client Management, CORE East Segment - Cigna Global Health Benefits (GHB) - Remote
$110K - $130K *
Transform client relationships by leading a dynamic team to achieve financial growth and enhance client experiences across a diverse portfolio. Drive strategic initiatives and foster collaboration to...
1 week ago
$120K - $145K *
Advance healthcare solutions by developing scalable ML systems, collaborating with cross-functional teams, and driving innovative AI methodologies to enhance patient outcomes and optimize operational...
Reposted today
Healthcare Program & Project Manager (Remote)
$80K - $95K *
Transform healthcare initiatives by leading projects from inception to completion. Coordinate teams, manage timelines, and ensure clear communication to drive organizational priorities and deliver mea...
Yesterday
Liability Claims Team Lead | Dedicated Client | East Coast States
$95K - $104K *
Lead a dynamic team to adjudicate complex liability claims, driving innovative solutions for diverse clients. Collaborate with experts to enhance processes and ensure exceptional service in a rapidly...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.