Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

Sort By: Relevance

$85K - $100K *

Develop high-quality, scientifically accurate content for medical affairs and promotional education. Collaborate with teams to ensure clarity and compliance while translating complex data into engagin...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $235K *

Join a team that's shaping the future of Medical Affairs by driving strategic client engagements and enhancing capabilities. This Director-level role balances client delivery and internal growth, focu...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Drive litigation strategy and outcomes in a dynamic P&C environment, leading a team to enhance operational effectiveness and improve policyholder experiences while managing diverse liability and cover...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $200K *

Elevate healthcare technology by owning mobile and web apps that enhance clinician workflows. Drive product direction, prioritize initiatives, and ensure patient safety while leveraging AI to improve...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $175K *

Empower client success by leading account health, driving growth, and managing budgets. Collaborate with cross-functional teams to deliver integrated campaigns while mentoring your account team and en...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Media

$70K - $100K *

Drive your career forward by managing key partnerships and delivering measurable results. This role blends strategic relationship management with consultative selling, ensuring partner success and gro...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Transform healthcare data products by leading strategy, execution, and cross-functional collaboration. Drive product-market fit and commercialization for API-based solutions, ensuring alignment with c...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Unlock financial insights as a key partner in operations finance, driving cost analysis, margin planning, and capacity modeling to enhance scalability and profitability while supporting strategic deci...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $206K *

Transform the accounting landscape by leading strategic initiatives that enhance operational efficiency, standardize processes, and drive technology integration, all while ensuring public company read...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$72K - $99K *

Join a team that's dedicated to enhancing employee experience and office operations. You'll manage daily office functions, foster a vibrant culture, and support executive initiatives, ensuring a welco...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $100K *

Grow strategic partnerships by leveraging immigration expertise to solve workforce challenges. Engage with HR, Legal, and executive leaders to drive business development and deliver tailored solutions...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Legal & Accounting

$118K - $142K *

Engage in comprehensive site monitoring and management for clinical trials, ensuring adherence to protocols and regulatory standards while providing high-quality care and support to study participants...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$105K - $140K *

Champion clinical trial excellence by leading a high-performing CRA team, ensuring compliance with ICH-GCP and local regulations while fostering a positive team culture and optimizing site relationshi...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Champion clinical services initiatives, driving strategic content development and mentoring teams to enhance market access and client success. Lead projects, ensure compliance with standards, and reso...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$88K - $154K *

Shape the future of contract administration by leading complex negotiations, ensuring compliance, and mitigating risks. Collaborate with cross-functional teams to drive successful outcomes in high-sta...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$108K - $162K *

Champion customer support by managing maintenance services and operations. Lead a team to ensure timely resolutions and enhance product performance while utilizing technical expertise and strategic pl...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$155K *

Transform complex challenges into impactful software solutions. Collaborate with engineers, designers, and justice leaders to drive product strategy and execution, enhancing the criminal justice syste...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Transform clinical quality by supporting training initiatives, monitoring clinician performance, and ensuring compliance with quality standards for successful operational processes and clinician suppo...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Champion cross-functional projects to enhance operational efficiency and achieve organizational goals. Lead initiatives from planning to completion, ensuring timely delivery within scope and budget wh...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$130K - $143K *

Optimize your career by developing and executing clinical marketing strategies that enhance customer engagement and drive adoption of innovative patient monitoring solutions. Collaborate with cross-fu...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$78K - $88K *

Join us to perform actuarial analyses and support healthcare consulting projects. Collaborate with multidisciplinary teams to develop insights, maintain models, and communicate findings effectively wh...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$71K - $100K *

Drive strategic initiatives by analyzing market trends and performance metrics. Collaborate with cross-functional teams to develop business cases and forecasts, ensuring data integrity and delivering...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$101K - $146K *

Elevate the insurance verification and authorization process by managing staff, developing strategies, and ensuring excellent service delivery while resolving complex patient financial needs in a coll...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$155K - $165K *

Drive success at leading Oracle Fusion Cloud projects, bridging technical expertise and financial acumen to deliver top-tier support and enhancements across Financial and Supply Chain modules with eff...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$80K - $115K *

Elevate your career by driving executive recruitment strategies, building diverse talent pipelines, and enhancing candidate experiences. Collaborate with hiring managers and represent the brand at ind...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.