Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

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$150K - $175K *

Accelerate growth through strategic demand generation and integrated marketing campaigns. Collaborate with Sales and Product teams to optimize the pipeline, drive revenue, and enhance customer engagem...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $165K *

Join us to drive the launch of a pioneering biotech product, enhancing healthcare provider engagement and patient outcomes across your territory while achieving sales targets in a dynamic, fast-paced...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $170K *

Champion growth by engaging complex life sciences accounts, driving value through strategic relationships. Navigate multifaceted deals with precision, collaborating across teams for impactful sales su...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$330K - $350K *

Unlock potential by driving strategic expansion within Global 2000 accounts. Manage complex SaaS deals, collaborate with cross-functional teams, and deliver measurable business outcomes through innova...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$122K *

Champion project success by leading interdisciplinary teams to deliver innovative solutions in the biotech and pharma sectors. Drive milestone achievement, manage budgets, and ensure compliance with p...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Unlock potential by leading a dynamic marketing team to drive E-commerce growth. Collaborate on strategy, optimize performance, and ensure creative alignment while fostering a high-impact work environ...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$75K - $158K *

Engage your expertise as a hands-on technical leader, designing and evolving enterprise solutions. Collaborate with cross-functional teams to drive innovation, ensure platform reliability, and deliver...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$170K - $205K *

Accelerate progress at driving U.S. sales strategy for a new kidney transplant product. This role requires strategic account management, cross-functional collaboration, and a focus on building relatio...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$235K - $250K *

Transform financial strategy and compliance in a dynamic fintech environment. Lead financial operations, banking relationships, and compliance initiatives to drive growth and manage risk effectively w...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $160K *

Lead the charge in delivering strategic and operational excellence across high-profile medical affairs accounts, fostering client relationships and guiding teams to achieve exceptional results in publ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Lead the SAP Analytics strategy and implementation, driving innovation in analytics solutions. Collaborate with stakeholders to deliver insights and manage teams, ensuring successful deployment of SAP...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$74K - $98K *

Champion regulatory audit excellence by leading PACE audits, ensuring compliance, and driving cross-functional collaboration to enhance operational readiness and continuous improvement across the orga...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Drive customer satisfaction and growth by nurturing relationships, identifying upsell opportunities, and collaborating on account strategies. Leverage industry insights to maximize account potential a...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $160K *

Drive operational excellence by leading a global team to deliver high-quality wellbeing programs. Collaborate with stakeholders to ensure effective execution, maintain standards, and enhance participa...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$330K - $390K *

Join a team that's driving enterprise-level strategic statistical leadership across Biostatistics. You'll oversee programs, mentor statisitians, and ensure collaboration for successful drug developmen...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Contribute to quality operations initiatives by reviewing study documents, supporting audits, and ensuring compliance with regulatory standards. Collaborate with cross-functional teams to enhance qual...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$79K - $194K *

Champion the standardization of financial posting logic across Oracle EBS, ensuring compliance and audit readiness. Collaborate with cross-functional teams to enhance federal financial processes and s...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Elevate customer success by guiding clients through their journey, maximizing product value, and fostering strategic partnerships. Collaborate cross-functionally to enhance user experience and drive r...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $192K *

Inspire commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful re...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Unlock potential by leading enterprise sales initiatives, managing complex accounts, and driving strategic growth. You will navigate technical discussions and deliver value-driven solutions to top-tie...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$98K - $163K *

Optimize federal grants management operations by assessing processes, identifying inefficiencies, and delivering actionable recommendations. Collaborate with stakeholders to enhance program outcomes a...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$69K - $125K *

Transform regulatory insights into actionable strategies by analyzing national and state legislative activities. Collaborate with legal and business teams to ensure compliance and support effective de...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$144K - $200K *

Help us lead a national sales team focused on public safety solutions. Drive recruitment, coaching, and team performance to enhance sales effectiveness in the corrections sector, while collaborating a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$80K - $95K *

Join a dynamic team as you manage clinical research sites, ensuring compliance and quality throughout all study phases. Build strong relationships, oversee monitoring activities, and contribute to tea...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$74K - $137K *

Lead the charge in transforming workflows with AI, driving adoption and measurable impact in legal, tax, and trade sectors. Collaborate with clients and teams to design, implement, and evaluate innova...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.