Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Manager, Clinical Operations
$136K - $171K *
Pioneer clinical trial excellence by leading operational planning and execution. Collaborate cross-functionally to ensure compliance, quality, and timely delivery of clinical studies while mentoring j...
1 week ago
Deployment Strategist - Crypto Investigations
$110K - $130K *
Unlock customer success by leading the delivery and adoption of data solutions, leveraging blockchain expertise to design tailored compliance workflows and build strong relationships with financial in...
4 weeks ago
$95K - $115K *
Drive the delivery and maintenance of Interactive Response Technology (IRT) systems, ensuring successful client interactions and project outcomes through effective oversight, training, and support man...
1 week ago
Vice President, Clinical Development
$350K - $430K *
Join a team that's at the forefront of ophthalmic genetic medicine development. Provide strategic oversight for clinical studies, ensuring patient safety and data integrity while collaborating with cr...
Reposted 3 weeks ago
Manager, Coding Hospital & Physician Services
$80K - $95K *
Elevate your career by managing coding operations, ensuring accuracy and compliance across healthcare settings. Lead educational initiatives for staff, optimize workflows, and drive improvements in co...
2 weeks ago
$112K - $131K *
Elevate your career by leading complex financial analyses and strategic initiatives. As a senior contributor, you'll drive enhancements in reporting, support business decisions, and mentor team member...
3 weeks ago
$110K - $130K *
Lead the creative vision and execution of impactful design assets, enhancing brand identity and streamlining production processes using AI tools. Collaborate across teams to deliver high-quality marke...
3 weeks ago
Advisor, International Sustainability
$113K - $188K *
Elevate your career by leading the strategic development of sustainability programs across international markets, focusing on carbon project design, risk management, and technical innovation to drive...
3 weeks ago
Associate Director, Patient Recruitment and Retention Execution Manager
$194K - $266K *
Champion patient engagement strategies by leading a dynamic team focused on optimizing recruitment and retention across clinical trials. Drive performance, enhance collaboration, and ensure successful...
1 week ago
$136K - $181K *
Take ownership of CRA management by leading teams, developing metrics, and ensuring compliance with monitoring standards. Drive continuous improvement and optimize effectiveness across the Site Manage...
Yesterday
$93K - $97K *
Contribute to program success by supporting planning, execution, and management of projects. Analyze data, prepare reports, and optimize resources to ensure objectives are met within scope, time, and...
1 week ago
Senior Director, Regulatory Affairs, CMC
$204K - $274K *
Champion the U.S. Biologics Regulatory CMC team by providing strategic leadership, ensuring timely regulatory submissions, and fostering collaboration among global stakeholders to drive innovative bio...
Reposted 3 days ago
Associate Director, US Pricing, Contracting and Channel Strategy
$157K - $256K *
Shape strategic pricing and channel strategies for innovative therapies, ensuring patient access and affordability. Lead cross-functional initiatives, optimize distribution models, and drive market in...
3 days ago
Senior Business Analyst, Supply Chain (Oracle Cloud SCM)
$119K - $145K *
Advance supply chain efficiency by optimizing operations, collaborating cross-functionally, and implementing innovative solutions. Engage with stakeholders to analyze performance metrics and support k...
Reposted 1 week ago
Associate Director, Medical Affairs- Hematology (northern CA/Nevada)
$176K - $287K *
Lead the charge in advancing scientific discourse by engaging KOLs and HCPs in Hematological Malignancies. Drive strategic medical initiatives while fostering relationships to enhance research and cli...
4 weeks ago
$114K - $185K *
Explore the frontier of veterinary pharmacology by leading in vivo PK/PD studies across multiple species. Collaborate with multidisciplinary teams to enhance drug candidates from early research throug...
Reposted 3 weeks ago
$155K - $160K *
Shape the future of data solutions by designing scalable architectures that drive AI and analytics initiatives. Collaborate with cross-functional teams to implement innovative strategies that enhance...
1 week ago
Sr. Manager, Analyst Relations
$165K - $190K *
Advance your career by shaping analyst relations and market perception in AI and automation. Collaborate with cross-functional teams to drive impactful evaluations and strategic narratives that enhanc...
1 week ago
Regional Health Physicist - South Central US
$110K - $151K *
Champion operational excellence by ensuring radiation safety and EHS compliance across cyclotron manufacturing and PET nuclear pharmacy facilities in the South Central US, while collaborating with cro...
1 week ago
Account Specialist (Worcester, MA)
$160K - $192K *
Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...
1 week ago
Senior Director, Corporate Sales
$212K - $270K *
Drive growth and strategy as a Senior Director, leading a high-performing sales team to achieve exceptional results in a dynamic, fast-paced environment focused on new business and expansion across di...
3 weeks ago
Associate Director, Product Quality
$117K - $189K *
Join a team that's shaping the future of pharmaceutical quality by leading compliance initiatives and building a robust Quality Management System to support innovative therapies in a dynamic, collabor...
2 weeks ago
$135K - $160K *
Innovate by leading the architectural transformation of a legacy platform into a scalable, AI-driven solution. Your expertise will guide modernization efforts while enhancing performance and security...
Reposted 3 weeks ago
Kranz EG Senior Accountant Consultant
$90K - $110K *
Join a team that's dedicated to delivering exceptional financial services. This role involves managing accounts payable, payroll, cash management, and month-end reconciliations while collaborating clo...
3 weeks ago
Sr. Solution Architect, Professional Services - Agentic AI
$121K - $132K *
Engage as a key technical leader in enterprise AI/ML architecture, collaborating with clients to design scalable solutions. Drive AI development and deployment, ensuring alignment with business needs...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.