Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Certified Medical Dosimetrist - Radiation (Remote)
$80K - $95K *
Shape the future of cancer treatment by collaborating with experts to create individualized radiation therapy plans. Leverage advanced tools and techniques in a supportive, fully remote environment fo...
6 days ago
Clinical Development Medical Director, Early Development - Cardiometabolic
$274K - $371K *
Lead the early phase clinical development of innovative therapeutics, collaborating across teams to design and execute trials. Your expertise will directly influence strategy, protocol development, an...
Reposted 1 week ago
$260K - $270K *
Unlock your potential as a Psychiatrist, providing advanced outpatient care via virtual platforms. Collaborate with multidisciplinary teams to deliver comprehensive treatment for diverse psychiatric c...
6 days ago
$160K - $200K *
Drive growth and strengthen relationships across community clinics and AICs. Develop new business and expand partnerships while collaborating with key decision-makers in a complex healthcare market. T...
2 weeks ago
Senior Oncology Account Manager - (Birmingham, AL | Remote)
$198K - $253K *
Advance your career by driving strategic growth in oncology sales. Leverage your expertise to build relationships, mentor peers, and influence market strategies while ensuring compliance and ethical e...
3 weeks ago
$150K - $180K *
Join a pioneering team to build an AI-enabled care delivery platform, bridging clinical expertise and engineering to create safe, effective patient care solutions. Drive innovation from concept to pro...
3 weeks ago
$80K - $100K *
Drive innovative palliative care solutions for members with complex needs, providing compassionate, evidence-based support through telehealth. Collaborate with interdisciplinary teams to enhance patie...
3 weeks ago
Biostatistics Director, Oncology Biosimilars- US Remote
$200K - $270K *
Join a team that's redefining biostatistics in clinical development. You will lead statistical strategy across multiple therapeutic areas, ensuring excellence in design, analysis, and reporting while...
2 weeks ago
Senior Oncology Account Manager, Saint Louis
$150K - $230K *
Help us drive oncology product success by building relationships with key stakeholders, promoting innovative therapies, and ensuring patient access while exceeding performance goals in a dynamic bioph...
1 week ago
$110K - $130K *
Join a team that's dedicated to enhancing client relationships and driving success. Oversee client performance, mentor staff, and ensure compliance while collaborating with various departments to deli...
Reposted yesterday
$110K - $130K *
Champion client success by overseeing relationships, ensuring operational excellence, and mentoring teams to exceed expectations. Utilize analytics to drive performance and resolve issues, fostering c...
5 days ago
Senior Associate, Strategy & Operations
$125K - $155K *
Champion strategic initiatives by connecting breakthrough chemistry with market opportunities. Collaborate across teams to drive government partnerships, proposals, and commercial growth, transforming...
2 weeks ago
Senior Scientific Director - Publications (Heme-Onc)
$150K - $180K *
Join us to lead the development and oversight of scientific content across therapeutic areas, ensuring strategic medical communication aligns with brand goals while managing a team and collaborating w...
4 weeks ago
$110K - $130K *
Optimize clinical trial operations by leading cross-functional teams, managing vendor relationships, and ensuring compliance with regulatory standards to drive successful study execution and patient e...
2 days ago
$110K - $130K *
Join us to lead the development and execution of clinical study designs, ensuring effective project management and collaboration across teams. Your expertise will drive the success of clinical trials...
2 weeks ago
Senior Consultant, Healthcare Finance (Healthcare & Medicaid Finance and Analysis)
$95K - $130K *
Unlock potential by driving healthcare finance consulting excellence. Collaborate with project teams to enhance service delivery through financial modeling, data analytics, and quality improvement ini...
1 week ago
Senior Case Manager RN - Oncology (Remote)
$79K - $127K *
Partner with us to deliver comprehensive case management services, ensuring quality care and optimal health outcomes for members with complex needs. Collaborate with healthcare teams to develop and im...
3 weeks ago
Manager of Bioinformatics (Oncology Product Development)
$140K - $175K *
Lead the charge in advancing oncology diagnostics by managing a team of bioinformaticians and data scientists, driving product development, and ensuring high-quality analysis and validation of ctDNA-b...
Yesterday
$80K - $95K *
Empower healthcare technology by enhancing clinical systems and integrations. Collaborate with IT and business stakeholders to optimize workflows, manage projects, and ensure system performance across...
1 week ago
Account Executive, Care Management
$80K - $95K *
Join our team to drive sales across a defined portfolio, engaging healthcare organizations with our innovative solutions. Own the sales cycle from prospecting to closing while collaborating with inter...
Reposted 4 weeks ago
Hematology Therapeutic Specialist (Michigan/Ohio)
$110K - $130K *
Drive success by educating healthcare providers on ZYNLONTA® in the Michigan/Ohio territory. Leverage insights to foster relationships, achieve sales goals, and enhance patient experiences through eff...
1 week ago
Scientific Partnership Medical Director
$299K - $369K *
Unlock your career potential by driving strategic medical partnerships with US health systems in oncology. Collaborate across functions to enhance evidence generation and meet healthcare priorities th...
Reposted 2 weeks ago
Senior Director, Counsel, Diagnostics & Medical Devices
$199K - $321K *
Join a dynamic team to provide strategic legal counsel on diagnostics and medical devices, ensuring compliance with FDA regulations and commercial strategies while collaborating across business units...
1 week ago
National Director, Integrated Specialty Practices
$160K - $200K *
Drive strategic growth and business development for National Accounts in Urology and Oncology, optimizing resources and leading negotiations to enhance healthcare outcomes through innovative diagnosti...
3 weeks ago
Global Value and Access Senior Manager - Rare Disease
$120K - $150K *
Drive global access strategies for an innovative rare disease treatment, collaborating across teams to enhance payer insights and develop impactful materials. Lead initiatives that shape market entry...
Today
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.