Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Program Analyst – Organizational Change Management (OCM)
$73K - $132K *
Drive organizational change by analyzing processes, engaging stakeholders, and implementing effective strategies. Collaborate with teams to enhance operational efficiency and ensure successful adoptio...
2 weeks ago
$114K - $165K *
Shape the future of compliance by leading governance initiatives, managing risk, and ensuring audit readiness. Collaborate across teams to enhance security and policy frameworks, driving effective com...
3 weeks ago
Director/Sr. Director Clinical Pharmacology
$262K - $284K *
Optimize pediatric drug development strategies as a clinical pharmacology leader, overseeing pharmacometric analyses and regulatory submissions, while translating complex data into actionable decision...
Reposted 4 weeks ago
Lead Application Modernization Consultant
$125K - $168K *
Pioneer application modernization efforts by leading agile teams, driving technical outcomes, and enhancing developer experiences. Collaborate with clients to deliver measurable business results while...
Yesterday
$135K - $160K *
Elevate our deal desk function by transforming processes into a scalable model. You'll implement AI tools, streamline order forms, and ensure efficient deal structuring while collaborating with cross...
4 weeks ago
EHR Application Principal Trainer
$67K - $100K *
Develop and deliver role-based training for EHR applications, ensuring curriculum accuracy and effectiveness. Collaborate with teams to optimize training environments and support user engagement in he...
1 week ago
$110K - $130K *
Drive healthcare transformation by leading advanced consulting initiatives, enhancing delivery systems, and improving health outcomes. Collaborate with clients and stakeholders to implement strategic...
2 weeks ago
$110K - $130K *
Elevate client relationships by leading Client Success teams to ensure operational excellence, proactive issue resolution, and strategic growth, while fostering collaboration across departments to enh...
2 weeks ago
Manager, Reputation and Consumer Insights
$120K - $150K *
Drive reputation management and consumer insights initiatives, enhancing brand trust and informing strategic decisions. Collaborate across teams to analyze data, identify trends, and improve consumer...
3 weeks ago
$80K - $145K *
Join a team that's advancing data analytics for VA modernization initiatives. Utilize SQL and Python to drive AI-enabled insights, enhance operational workflows, and support decision-making through ri...
2 days ago
Physician - Emergency Medicine
$210K - $250K *
Shape the future of emergency care by providing critical healthcare services in a dynamic environment. Collaborate with a multidisciplinary team to treat diverse patient needs, ensuring high-quality c...
4 weeks ago
$140K - $160K *
Accelerate progress at a dynamic tech firm by owning the full sales cycle for mid-market practices. Collaborate with leadership to shape strategy and drive impactful relationships, ensuring success in...
1 week ago
Principal Consultant - Senior SAP Sales Executive
$150K - $180K *
Transform the SAP sales landscape by leveraging your extensive network and expertise to drive new business acquisition in the manufacturing sector. Own the full sales cycle, from lead generation to cl...
Yesterday
Occupational Therapist Home Health
$80K - $95K *
Unlock potential by providing in-home occupational therapy services, evaluating safety, assessing functional needs, and implementing personalized treatment plans to enhance patient independence and qu...
2 weeks ago
Strategic Partner Executive, Industry Partnerships
$140K - $160K *
Shape the future of healthcare by building strategic partnerships that enhance behavioral health referrals. Collaborate with leadership to drive growth, develop tailored solutions, and maintain strong...
2 weeks ago
$80K - $95K *
Transform compensation strategies by analyzing job evaluations, benchmarking, and implementing efficient processes. Collaborate with management to ensure competitive pay practices and support business...
2 weeks ago
$160K - $200K *
Drive strategic growth and operational excellence in cardiology, fostering physician partnerships and overseeing clinical and financial performance to enhance patient care and organizational success...
Yesterday
Epic Professional Billing Analyst 2
$70K - $100K *
Join a team that's dedicated to optimizing Epic Resolute Professional Billing. Support daily operations, troubleshoot issues, and enhance workflows while collaborating with analysts and users to ensur...
2 weeks ago
$112K - $128K *
Drive business development for large-scale podcast and broadcast campaigns, fostering client relationships and achieving revenue growth. Collaborate with cross-functional teams to deliver innovative a...
2 weeks ago
Program Executive, Early Phase
$300K - $350K *
Join a team that's driving innovation in early clinical development. Lead cross-functional strategies and execution for a high-priority program, ensuring alignment and decision-making to advance a pot...
2 weeks ago
$110K - $130K *
Elevate your career by collaborating with cross-functional teams to enhance business operations, streamline processes, and drive value through effective analysis and documentation. Your expertise will...
2 weeks ago
Senior Business Systems Analyst - Healthcare Payor Specialized
$81K - $142K *
Lead the design and development of enterprise data management solutions, collaborating with stakeholders to analyze requirements and enhance data processing capabilities using advanced technologies in...
3 days ago
Senior Analyst, Decision Science (Client Marketing)
$105K - $129K *
Elevate client engagement through data-driven insights! As a Senior Analyst, you'll analyze performance metrics, enhance marketing strategies, and drive client retention, ensuring impactful decisions...
1 week ago
Senior Account Manager, Life Sciences (Los Angeles)
$120K - $150K *
Drive customer satisfaction and sales in life sciences by leveraging your expertise to build relationships and execute strategic initiatives with key accounts in academia and industry...
2 weeks ago
Lead Director, Risk Adjustment Performance Reporting and Insights
$100K - $231K *
Advance your career by leading healthcare analytics initiatives that transform data into impactful insights, drive performance, and enhance decision-making across departments while fostering innovatio...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.