Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Regulatory Affairs Consultant - Regulatory Generalist
$100K - $120K *
Take ownership of regulatory support for pharmaceutical programs, managing IND and NDA submissions, health authority interactions, and lifecycle maintenance. Collaborate with cross-functional teams to...
3 weeks ago
$119K - $142K *
Join a team that's redefining digital operations by leading strategic initiatives, enhancing customer experiences, and driving growth in a fast-paced environment. Shape the future of MODAL Digital whi...
3 weeks ago
Regional Modality Leader - Mammography (Houston)
$110K - $130K *
Lead the charge in driving transformative growth by cultivating strategic relationships and delivering on sales targets within a dynamic healthcare environment, ensuring sustained profitability and ma...
3 weeks ago
$78K - $156K *
Join a team that's dedicated to enhancing business systems through design, configuration, and support. As a Senior Application Analyst, you'll lead improvements, mentor junior analysts, and ensure sea...
2 weeks ago
$164K - $305K *
Lead the charge in developing strategic relationships with C-suite executives to drive growth, retention, and value realization across complex health systems, ensuring integrated solutions and measura...
1 week ago
Sr. Analyst, Pricing Analytics
$89K - $134K *
Explore your potential as a key analytical consultant, leveraging data to optimize drug pricing and enhance pharmacy relationships while collaborating across multiple functions to drive strategic grow...
1 week ago
People & Organization Generalist, Leave of Absence
$81K - $90K *
Manage the leave of absence program, ensuring compliance and support for associates. Collaborate with stakeholders to enhance leave experiences and ADA accommodations while maintaining accurate record...
6 days ago
$72K - $116K *
Unlock potential as a mid-level actuarial analyst, applying statistical techniques to enhance insurance pricing, claims analysis, and profitability studies while progressing through the Actuarial Exec...
2 weeks ago
Principal Consultant - Senior SAP Account Manager
$150K - $180K *
Unlock potential by managing and expanding relationships with large enterprise clients. Drive strategic account growth and new business development in the SAP ecosystem, ensuring client satisfaction a...
3 weeks ago
Senior Account Executive level
$85K - $95K *
Transform integrated communications for vaccine brands by managing client relations, strategic planning, and digital engagement. Leverage traditional and digital strategies to drive impactful outcomes...
4 weeks ago
$63K - $96K *
Engage in the support and optimization of multi-user operating systems and applications, collaborating with users and IT teams to enhance system functionality and ensure effective use of technology ac...
Yesterday
$93K - $123K *
Join a team that's dedicated to enhancing patient safety and compliance through effective case management. This role involves coordinating complex healthcare cases, collaborating with stakeholders, an...
6 days ago
Director NovaOS Product Owner - 1 of 4
$194K - $361K *
Lead the development of innovative NovaOS capabilities, ensuring alignment with business goals and driving continuous improvement through collaboration across cross-functional teams. Deliver measurabl...
Reposted 3 days ago
$92K - $120K *
Join a dynamic team as a Medical Claims Auditor, ensuring compliance and integrity in healthcare payments. Collaborate with cross-functional teams to identify fraud, waste, and abuse while leveraging...
Yesterday
Healthcare Payment Solutions Consultant - Enterprise Market
$126K - $154K *
Transform healthcare payment solutions by driving business growth and optimizing client relationships. Leverage your expertise to develop tailored proposals and secure long-term partnerships with larg...
1 week ago
Manager, Strategic Client Solutions
$100K - $120K *
Accelerate client relationships by managing strategic accounts, driving revenue growth, and expanding service lines. Collaborate with internal teams to ensure client satisfaction and deliver tailored...
3 days ago
Senior Medical Science Liaison - Obesity & Related Conditions - IA/NE/SD
$172K - $233K *
Engage with healthcare leaders to advance scientific knowledge and improve patient outcomes in obesity care. Collaborate with internal and external stakeholders, support research initiatives, and ment...
2 days ago
$100K - $120K *
Contribute to US HR operations by ensuring compliance with employment laws, managing employee data, and supporting onboarding/offboarding processes while collaborating with global HR teams for seamles...
Reposted 2 weeks ago
Category Growth Manager, Women's Hormones
$130K - $150K *
Drive growth and strategy for key telehealth categories by leveraging market insights, customer feedback, and cross-functional collaboration to enhance performance and deliver exceptional customer exp...
6 days ago
Executive Underwriter, Central
$150K - $190K *
Lead the charge in underwriting and managing complex enterprise accounts, driving profitable business through strategic broker partnerships while mentoring junior underwriters and shaping portfolio st...
2 weeks ago
Principal Consultant - Senior SAP Account Manager
$150K - $180K *
Grow enterprise SAP relationships by managing key accounts and driving new business. Leverage your expertise to expand client portfolios, develop strategic plans, and ensure client satisfaction while...
Today
Informatics Lead, Clinical Intelligence
$117K - $161K *
Drive impactful clinical intelligence initiatives by analyzing AI opportunities, conducting feasibility studies, and collaborating with cross-functional teams to enhance patient care and operational e...
2 weeks ago
$140K - $170K *
Join a team that's dedicated to advancing tuberculosis (TB) prevention and care. As a senior technical advisor, you'll lead innovative strategies, collaborate with global partners, and enhance TB prog...
1 week ago
Senior UX Researcher, Quantitative
$120K - $145K *
Lead quantitative user research across product lines, shaping strategy and answering critical questions with data-driven insights. Collaborate with teams to prioritize research that mitigates risk and...
Yesterday
$100K - $120K *
Transform the insurance appeals process by managing, researching, and drafting compliant responses to billing deductions. Collaborate with legal teams to enhance efficiency and build strong relationsh...
Reposted yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.