Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Account Specialist, Olympia, WA
$160K - $192K *
Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...
1 week ago
Customer Success Director (Oracle Focused)
$100K - $125K *
Engage with strategic Oracle customers to drive success through relationship management, implementation guidance, and value realization. Champion customer outcomes and optimize their journey with Redw...
1 week ago
$130K - $150K *
Unlock potential by leading the full sales cycle in healthcare, engaging C-suite executives and driving strategic decisions. Leverage your experience to meet quotas, build account strategies, and enha...
Reposted today
Sr. Manager, Pricing and Deal Desk
$160K - $170K *
Shape the future of pricing strategy by leading complex deal governance and analytics. Collaborate across teams to enhance deal integrity and leverage AI-driven tools for efficient pricing models, ens...
4 weeks ago
Executive Director of Product Management , Resiliency
$150K - $214K *
Join a team that's redefining healthcare product management through innovative supply chain solutions. Lead cross-functional initiatives and shape the future of resilience in healthcare with strategic...
Reposted 4 weeks ago
$128K - $145K *
Support the full life cycle of vendor contracts, from negotiation to execution. Collaborate with stakeholders to manage legal risks and ensure compliance in a fast-paced environment, focusing on healt...
2 days ago
Principal RAS Partner & Educator
$98K - $132K *
Transform healthcare by leading Risk Adjustment strategies and educational initiatives. Collaborate with teams to enhance coding accuracy and documentation, ensuring compliance and delivering impactfu...
1 week ago
$111K - $167K *
Join a team that's driving healthcare transformation by leading client integration initiatives. Collaborate across departments to ensure seamless transitions, operational readiness, and long-term succ...
Yesterday
$122K - $184K *
Drive operational excellence by leading physician practices in Ohio. Collaborate with clinical and regional teams to enhance performance, accountability, and patient experience while translating data...
1 week ago
$95K - $115K *
Transform patient care by delivering comprehensive primary health services, utilizing advanced practice skills to assess, diagnose, and treat diverse health conditions while collaborating with physici...
3 weeks ago
Licensed Clinical Social Worker (Remote)
$78K - $92K *
Engage in impactful virtual counseling for patients with acute mental health conditions. Develop treatment plans, exercise clinical judgment, and collaborate with multidisciplinary teams to enhance be...
1 week ago
Associate Director, Field Medical Affairs Cutaneous Oncology (Pacific Northwest)
$176K - $287K *
Shape the future of oncology by cultivating relationships with KOLs, providing critical insights, and supporting research initiatives. Drive awareness and education while ensuring compliance and integ...
1 week ago
$150K - $180K *
Join a team that's redefining customer success by leveraging AI to enhance the post-sale journey. Lead and scale a dynamic team while driving retention and expansion for enterprise clients in a fast-p...
1 week ago
Medical Science Liaison, CNS - AR, LA, OK
$150K - $224K *
Advance patient outcomes by leveraging your expertise in CNS as a Medical Science Liaison. Collaborate with healthcare providers and stakeholders to deliver evidence-based insights and drive strategic...
Yesterday
$150K - $180K *
Champion growth by leading national accounts, driving strategy, and enhancing partnerships with specialty distributors and GPOs. Leverage expertise to ensure product availability and exceed corporate...
3 weeks ago
Nationwide- Clinical Psychologist (remote)
$80K - $95K *
Support patient evaluations by conducting psychological assessments and collaborating with a clinical team to enhance diagnostic outcomes and treatment plans. Leverage expertise in standardized testin...
4 weeks ago
Manager, Clinical Data Management
$110K - $130K *
Innovate within a dynamic team, driving impactful projects and solutions that enhance operational efficiency and foster growth across multiple departments. Your expertise will shape strategic initiati...
Yesterday
Associate Director, Access Strategy and Marketing
$177K - $221K *
Manage the strategy and execution of access marketing for oncology products, focusing on value propositions for payers and healthcare providers. Collaborate with cross-functional teams to ensure effec...
3 days ago
Director of Clinical Quality and Outcomes (BCBA-D Preferred)
$110K - $130K *
Innovate clinical quality systems for scalable care delivery, ensuring standards meet payer expectations and driving measurable performance improvements across independent health providers...
Reposted 4 weeks ago
$108K - $156K *
Empower your career by leading revenue analytics, overseeing financial analysis, and enhancing payer contract strategies. Collaborate with cross-functional teams to optimize reimbursement and drive or...
3 weeks ago
Vice President, Integrated Medicines Business — East
$300K - $500K+*
Join a dynamic team as a senior leader driving portfolio performance across the eastern U.S. Oversee regional execution, manage a team of directors, and collaborate on national strategies to enhance b...
Today
Principal Client Success Manager
$110K - $130K *
Unlock potential by managing complex relationships with multi-hospital systems, guiding clients through intricate reimbursement processes, and influencing strategies that drive partnerships and operat...
Reposted 4 weeks ago
Regional Sales Director, Lab Diagnostics - Rocky Mountains
$159K - $218K *
Transform sales performance by leading a dynamic team to exceed revenue goals across diverse laboratory solutions in a defined region, fostering customer relationships and driving strategic initiative...
2 weeks ago
$100K - $140K *
Transform your career by leveraging your RCM expertise to drive sales success. Collaborate with cross-functional teams to enhance customer experiences and optimize billing solutions for small to mediu...
3 weeks ago
Project Attorney, Transactions
$90K - $135K *
Join a team that's transforming legal transactions with cutting-edge technology. As a Project Attorney, you will lead projects, leverage machine learning tools, and collaborate to drive innovative out...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.