Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Lead, Operations Strategy - Specialty Services Implementation
$90K - $100K *
Join a dynamic team to drive the implementation of innovative service lines, enhancing clinician and patient experiences. Collaborate cross-functionally to optimize operations and lead initiatives tha...
2 weeks ago
Associate Director, Analytics Governance & Operations
$152K - $283K *
Accelerate analytics governance and operations by leading initiatives that enhance decision-making processes, streamline reporting, and modernize workflows across teams, ensuring effective collaborati...
2 days ago
$93K - $120K *
Join a dynamic team as you manage clinical data throughout study lifecycles, ensuring compliance and quality. Collaborate with cross-functional teams to drive data strategy and support innovative solu...
3 weeks ago
$128K - $192K *
Unlock potential by driving new business growth through actionable health intelligence. Build relationships, identify client needs, and showcase solutions to enhance employee wellbeing and manage heal...
Yesterday
Enterprise Account Executive, Apromore
$141K - $214K *
Engage with enterprise clients to drive Agentic AI adoption, leveraging your expertise in process intelligence to deliver bespoke B2B solutions that enhance operational efficiency and foster lasting r...
Reposted 1 week ago
$110K - $130K *
Transform your career by leading full-cycle recruiting for GTM roles. Collaborate with executives to define hiring standards, build strong talent pipelines, and drive strategic hiring initiatives in a...
2 weeks ago
Mid-Market Account Executive, Healthcare SaaS
$80K - $95K *
Join a team that's driving growth in mid-market healthcare by building relationships, managing a dynamic sales pipeline, and closing new business opportunities in a fast-paced SaaS environment...
2 weeks ago
Clinical Care Manager, Transitions of Care
$69K - $101K *
Join us to enhance member health outcomes through holistic care management, collaborating with multidisciplinary teams to support individuals with complex needs. Utilize assessments and interventions...
3 weeks ago
Director, GCP Inspection Management- Americas
$172K - $232K *
Lead the GCP Inspection Management team to ensure inspection readiness and compliance. Oversee strategy development, cross-functional collaboration, and risk mitigation for successful regulatory inspe...
3 weeks ago
Advisor, Bio Sample Operations - DMPK
$153K - $268K *
Empower your career by leading bio sample operations across clinical studies. Oversee end-to-end processes, ensuring compliance and quality while collaborating with cross-functional teams and external...
6 days ago
Regional Sales Director - San Francisco
$180K - $215K *
Drive regional sales success by leading a high-performing team, executing launch strategies, and fostering customer relationships to achieve business objectives in a dynamic environment...
1 week ago
CMC Program Lead TLX597 & TLX66
$135K - $160K *
Lead the charge in developing and executing CMC strategies for antibody-based radiopharmaceuticals, ensuring alignment with Stage-Gate requirements while managing cross-functional teams and external p...
2 days ago
$140K - $175K *
Empower scientific innovation by collaborating within product pods to develop and evaluate real-world evidence agents. Drive impactful research and ensure scientific rigor while partnering with indust...
1 week ago
Therapeutic Sales Specialist - Chicago South
$155K - $210K *
Unlock potential by driving sales excellence in a dynamic territory, championing patient needs, and executing strategic business plans. Collaborate with cross-functional teams to enhance customer sati...
Yesterday
$160K - $190K *
Empower your career by partnering with the Science Leadership Team to drive strategic initiatives, enhance operational effectiveness, and translate scientific vision into impactful outcomes across div...
1 week ago
Staff Bioinformatics Scientist, Clinical Applications
$146K - $196K *
Transform genomic insights into clinical applications by designing automated solutions and integrating AI/ML approaches. Collaborate with cross-functional teams to enhance variant curation and ensure...
1 week ago
Clinical Psychologist (Remote & Night Shift)
$145K - $155K *
Join a team that's dedicated to providing virtual behavioral health services to military personnel. Utilize your expertise in clinical psychology to deliver evidence-based treatments and support patie...
1 week ago
$110K - $130K *
Lead strategic initiatives by managing complex projects from inception to launch. Collaborate across teams to implement new markets and contracts, ensuring compliance and operational readiness in a dy...
3 days ago
Drug Discovery Resource Outsourcing Manager
$110K - $130K *
Engage in early-stage drug discovery by triaging research requests, managing CRO partnerships, and ensuring seamless execution of outsourced projects. Leverage scientific expertise and Mandarin fluenc...
2 weeks ago
Lead Product Analyst - Ancillary Products
$94K - $151K *
Join a team that's shaping the future of insurance products by leading strategic initiatives, ensuring compliance, and driving market analysis. Collaborate with product managers to define vision and e...
2 weeks ago
$250K - $286K *
Shape the future of sales by leading a dynamic team to drive new business, refine strategies, and enhance customer experiences in a fast-paced SaaS environment, while mentoring leaders and achieving a...
3 weeks ago
Clinical Sales Specialist, Pulmonary
$110K - $130K *
Unlock your potential by driving sales of innovative pulmonary solutions. Collaborate with diverse stakeholders to enhance patient care and achieve sales targets in a dynamic healthcare environment. J...
Reposted 4 days ago
Staff Decision Scientist, Advanced Analytics
$130K - $242K *
Lead advanced analytics initiatives to enhance MAU insights, driving growth through experimentation and causal inference. Collaborate across teams to establish standards and leverage AI for scalable s...
2 days ago
Senior Consultant, Oracle EPM Cloud
$125K - $150K *
Unlock your potential as you drive Oracle EPM Cloud Planning solutions, supporting clients in their transformations. Leverage your expertise to configure, implement, and coach while enhancing project...
Reposted 1 week ago
Director, Sales & Operation Planning
$130K - $160K *
Transform the planning landscape by leading integrated sales and operations processes. Drive cross-functional collaboration, develop robust planning models, and ensure alignment on business objectives...
Reposted yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.