Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

Sort By: Relevance

$90K - $150K *

Unlock member value by managing pharmacy solutions, optimizing contract use, and fostering relationships with healthcare systems to enhance operational efficiency and savings...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$130K - $140K *

Help us drive the adoption of innovative colorectal cancer screening solutions by effectively engaging healthcare providers through education, consultation, and strategic support in your assigned terr...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $140K *

Grow your career with a dynamic role in clinical support, training surgical teams, and ensuring optimal patient outcomes in complex procedures. Collaborate closely with medical professionals, manage i...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $192K *

Join a team that's driving commercial success by engaging healthcare providers, building relationships, and supporting innovative therapies. Your expertise will be pivotal in executing business plans...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$208K - $220K *

Drive enterprise leadership in clinical quality and regulatory readiness, ensuring consistent standards and governance across regions. Collaborate with stakeholders to translate quality insights into...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$170K - $205K *

Transform sales strategies by driving key account growth and fostering relationships in the healthcare sector. Collaborate cross-functionally to establish a strong foundation for a new kidney transpla...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Unlock operational excellence by leading multi-site Ambulatory Surgery Centers. Drive growth strategies, optimize performance, and foster strong partnerships with physician leaders while managing sign...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Join a dynamic team to enhance mobile experiences by developing and maintaining iOS features. Collaborate across disciplines to create intuitive financial workflows while ensuring security, performanc...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$132K - $193K *

Unlock potential by leading the enterprise employee listening strategy, enhancing assessment science, and applying analytics to drive data-informed talent decisions. Collaborate with cross-functional...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$176K - $287K *

Engage with KOLs and HCPs to share scientific data on B-Cell Malignancies. Collaborate with researchers and decision-makers to drive medical strategy and support clinical trials, contributing to impac...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$140K - $185K *

Unlock the power of enterprise data as you design and implement Master Data Management solutions that enhance healthcare operations, drive analytics, and enable AI-driven decision-making with trusted...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $143K *

Join a dynamic team as you lead clinical trials, ensuring successful delivery through collaboration and strategic planning while managing clinical project operations and mentoring team members in a re...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive customer success by managing key accounts, ensuring satisfaction, and expanding revenue through upselling. Collaborate with internal teams to align customer needs with solutions, while leveragin...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join us in shaping the future of maternal and newborn health by leading innovative strategies in commodity financing and procurement. Drive impactful change at global and country levels to ensure esse...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $90K *

Elevate community engagement by building trusted relationships with senior living staff and residents. Act as a vital connector, ensuring seamless access to on-site care services while fostering colla...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Drive growth initiatives by identifying and nurturing new business opportunities within the Dept of Army market. Collaborate with cross-functional teams to build relationships and ensure alignment wit...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $90K *

Shape the future of Cell and Gene Therapy by providing expert application support, driving customer integration, and enhancing product utilization through collaboration and technical guidance across t...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K *

Elevate sales strategies by owning the full sales cycle, building C-Suite relationships, and delivering impactful solutions to healthcare organizations across the Western US...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $140K *

Accelerate the growth of colorectal cancer screening solutions by engaging healthcare providers and driving product adoption. Collaborate with partners while strategically planning to maximize market...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$158K - $185K *

Unlock your potential by leading the design and delivery of a transformative Medicaid data platform. Collaborate with stakeholders and guide teams to modernize healthcare systems through innovative cl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $220K *

Unlock potential by leading agent acquisition efforts to drive growth, enhance sales processes, and optimize recruitment strategies. Collaborate with teams to build a high-performing sales organizatio...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Media

$80K - $95K *

Transform eDiscovery management by driving operational excellence, ensuring timely project delivery, and enhancing workflow efficiency. Collaborate with stakeholders to uphold quality standards and fo...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$95K - $120K *

Elevate clinical trial success by providing expert oversight and guidance. Collaborate with cross-functional teams to ensure compliance, quality, and timely execution of monitoring activities while fo...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate partner success by managing strategic mid-market and enterprise relationships. Drive revenue growth through effective onboarding, enablement, and co-selling, while collaborating cross-function...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $190K *

Join us as a strategic advisor, providing legal counsel on commercial contracts, AI products, and technology licensing. Collaborate with cross-functional teams to drive proactive solutions and support...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.