Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Case Manager - Registered Nurse - South Region
$60K - $129K *
Partner with us to enhance health outcomes through a comprehensive, collaborative case management approach, engaging with clients and healthcare providers to optimize care plans and ensure quality ser...
Reposted 1 week ago
Dir, EHR Revenue Cycle Applications
$141K - $211K *
Transform clinical and revenue-cycle operations by leading cross-functional teams to optimize technology solutions, ensuring efficient charge capture and financial reporting while enhancing patient sa...
6 days ago
Lead Analyst, Business Intelligence
$111K - $167K *
Join a dynamic team as a strategic analytics partner, driving insights and performance improvements across revenue cycle operations. Collaborate with leaders to define KPIs, analyze data, and create i...
1 week ago
$110K - $130K *
Transform your career by driving sales for innovative SaaS solutions in a dynamic environment. Leverage your expertise to engage Fortune 1000 clients, navigate complex sales cycles, and exceed revenue...
3 weeks ago
RN, Cancer Screening & Prevention
$110K - $120K *
Advance patient care at our Virtual Cancer Clinic by providing essential support, education, and coordination for cancer screening and prevention, ensuring timely follow-up and compassionate care for...
2 weeks ago
$105K - $125K *
Transform coding quality and efficiency as a senior expert in radiology coding. Collaborate with cross-functional teams to enhance processes, provide guidance, and drive best practices, ensuring excep...
1 week ago
Senior Manager Medical Economics - QuickBase Developer
$82K - $182K *
Develop and maintain QuickBase applications while leading complex analytics projects. Ensure data integrity and support clinical performance reporting. Collaborate with stakeholders to drive continuou...
1 week ago
$80K - $95K *
Join a team that's dedicated to enhancing patient safety through data analysis, audits, and collaboration across departments. Drive improvements in EHR software and support quality initiatives to ensu...
1 week ago
Senior Manager Medical Economics
$82K - $182K *
Analyze healthcare costs and quality outcomes to drive value-based care strategies, collaborating with clinical and financial teams. Lead data-driven insights and financial modeling to enhance operati...
Reposted 2 days ago
Head of Partner Programs, Strategy and Operations
$160K - $238K *
Build and scale the Partner Operations function, turning complexity into leverage by designing systems and processes that enhance partnerships and align with revenue goals for measurable impact and st...
Reposted 2 weeks ago
$80K - $95K *
Drive revenue cycle operations by managing processes from entry to adjudication. Lead teams, implement efficiencies, and ensure compliance while optimizing cash collections and performance metrics for...
Reposted 3 days ago
$80K - $95K *
Lead the design and delivery of impactful training programs, creating engaging learning materials and facilitating sessions to enhance employee skills and knowledge across various business units. Driv...
Today
$85K - $97K *
Shape the future of healthcare by conducting clinical case reviews and enhancing product quality for an AI-driven clinical platform. Collaborate with care teams to ensure accurate alert functionality...
4 weeks ago
Clinical Applications Specialist, General Imaging Ultrasound- Boston
$110K - $165K *
Join a team that's dedicated to enhancing clinical education and customer experience. In this role, you'll drive training strategies and support ultrasound product implementation, impacting patient ca...
1 week ago
Client Growth & Success Principal Manager- Enterprise Accounts
$150K - $175K *
Shape the future of client partnerships by driving strategic growth and success for large enterprise organizations. Collaborate with cross-functional teams to deliver exceptional value and measurable...
1 week ago
Nurse Practitioner | Avera at Home
$92K - $110K *
Provide comprehensive medical care by assessing and treating patients, collaborating with physicians, and ensuring quality health education. Contribute to patient safety and care standards while maint...
2 weeks ago
Field Pharmacy Account Manager
$90K - $150K *
Unlock member value by managing pharmacy solutions, optimizing contract use, and fostering relationships with healthcare systems to enhance operational efficiency and savings...
Today
Specialty Development Executive - North Central Territory
$130K - $140K *
Help us drive the adoption of innovative colorectal cancer screening solutions by effectively engaging healthcare providers through education, consultation, and strategic support in your assigned terr...
Reposted 2 weeks ago
Shreveport, LA based Clinical Specialist - Remote, USA
$100K - $140K *
Grow your career with a dynamic role in clinical support, training surgical teams, and ensuring optimal patient outcomes in complex procedures. Collaborate closely with medical professionals, manage i...
Reposted 2 days ago
Account Specialist (Cleveland, OH)
$160K - $192K *
Join a team that's driving commercial success by engaging healthcare providers, building relationships, and supporting innovative therapies. Your expertise will be pivotal in executing business plans...
1 week ago
Head of Clinical Quality and Regulatory
$208K - $220K *
Drive enterprise leadership in clinical quality and regulatory readiness, ensuring consistent standards and governance across regions. Collaborate with stakeholders to translate quality insights into...
1 week ago
Key Account Manager - Baltimore, MD
$170K - $205K *
Transform sales strategies by driving key account growth and fostering relationships in the healthcare sector. Collaborate cross-functionally to establish a strong foundation for a new kidney transpla...
3 weeks ago
$120K - $150K *
Unlock operational excellence by leading multi-site Ambulatory Surgery Centers. Drive growth strategies, optimize performance, and foster strong partnerships with physician leaders while managing sign...
Reposted 1 week ago
Director, Field Medical Affairs, West Coast
$160K - $190K *
Champion a national team of Medical Science Liaisons focused on obesity, driving strategy and KOL engagement. Lead cross-functional collaboration and ensure compliance while developing high-performing...
Reposted 2 days ago
$125K - $150K *
Join a dynamic team to enhance mobile experiences by developing and maintaining iOS features. Collaborate across disciplines to create intuitive financial workflows while ensuring security, performanc...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.