Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Manager, Clinical Data Acquisition
$73K - $130K *
Drive the acquisition and usability of clinical data to enhance healthcare outcomes. Collaborate with diverse teams to analyze data gaps, implement integrations, and optimize processes, ensuring timel...
3 weeks ago
$80K - $95K *
Join a team that's redefining healthcare recruiting by building and scaling a high-impact Direct Employer business through innovative sales strategies and cutting-edge technology, driving growth direc...
Reposted 4 weeks ago
$108K - $130K *
Drive program delivery across multiple products, ensuring timely outcomes by managing risks, dependencies, and stakeholder priorities. Collaborate cross-functionally to maintain accurate project data...
3 weeks ago
$85K - $100K *
Elevate healthcare interoperability by designing and supporting MEDITECH interfaces. Collaborate with teams to enhance data exchange, improve patient care, and ensure seamless integration across syste...
3 weeks ago
South Central, Key Account Manager, Cattle
$80K - $95K *
Unlock potential by driving sales growth and fostering customer relationships in the cattle healthcare sector. Collaborate with a dynamic team to achieve strategic objectives and enhance brand presenc...
2 weeks ago
Assistant General Counsel, Transactions
$220K - $270K *
Join a team that's shaping the future of renewable energy finance by managing complex transactions and driving innovative legal solutions. Collaborate cross-functionally to optimize processes and enha...
Yesterday
Senior Software Engineer, Full-Stack
$140K - $180K *
Champion innovation by developing full-stack web applications using TypeScript. Collaborate in a dynamic, remote-first team to deliver engaging user experiences, streamline operations, and lead techni...
Reposted 2 weeks ago
$120K - $150K *
Shape the future of brand strategy by leading integrated initiatives, translating insights into actionable plans, and collaborating with cross-functional teams to deliver impactful solutions across as...
3 weeks ago
Senior Consultant - Clinical Operations
$89K - $148K *
Drive your career with impactful consulting in healthcare, enhancing operational efficiency and financial performance for provider organizations through data analysis and project management...
6 days ago
$74K - $87K *
Transform customer experiences by leading Unanet ERP implementations, ensuring successful configurations and training for Government Contracting clients. Manage multiple projects, driving adoption and...
3 weeks ago
Clinical Laboratory Supervisor
$91K - $100K *
Join a team that's dedicated to excellence in clinical lab operations, overseeing staff performance and ensuring compliance with quality standards. Lead daily activities, foster team development, and...
4 weeks ago
Sr. Human Resources Business Partner
$100K - $120K *
Pioneer a high-performing culture by partnering with leaders to deliver strategic HR solutions that enhance employee engagement, retention, and growth in a dynamic, mission-driven environment...
2 weeks ago
$160K - $190K *
Elevate healthcare solutions by transforming complex data needs into scalable systems. Collaborate with cross-functional teams to design and build data pipelines and insightful dashboards that enhance...
Reposted 2 weeks ago
Senior Vice President, Delivery - Denials Resolution and Payment Compliance
$180K - $220K *
Shape the future of healthcare delivery by leading operations in denials resolution and payment compliance. Drive performance, quality, and financial outcomes while building a high-performing team and...
Reposted today
$120K - $145K *
Shape the future of legal operations by leading a dynamic team focused on automation and technology. Drive efficiency in contract management and vendor relationships while defining metrics that enhanc...
3 weeks ago
$252K - $315K *
Champion psychiatric practice excellence by developing standards and frameworks, enhancing clinician support, and driving quality improvement initiatives to elevate patient outcomes and operational ef...
3 weeks ago
Senior Advisor, Vaccine & Clinical Case Management
$91K - $151K *
Shape the future of public health by leading the development of a statewide vaccine management and clinical case management system, ensuring seamless integration and support for local health departmen...
2 weeks ago
CMC Program Lead - Illuccix and Gozellix
$125K - $150K *
Join a team that's dedicated to advancing radiopharmaceuticals! Lead CMC strategies and cross-functional collaboration to ensure successful readiness for commercial viability, market expansion, and co...
4 weeks ago
Associate Director, Clinical Supply Chain (Remote)
$150K - $185K *
Architect comprehensive clinical supply strategies for global trials. Collaborate across functional teams to secure timely, compliant drug supply while managing risks and inventory effectively, ensuri...
Reposted 3 days ago
Analyst/Senior Analyst, Business Operations & Strategy
$95K - $130K *
Tackle strategic business challenges by leveraging data insights to drive growth. Collaborate cross-functionally to enhance operational efficiency, support marketing initiatives, and influence product...
Yesterday
Director, Business Strategy and Operations, Global Clinical Development Operations (GCDO)
$192K - $288K *
Join us as a strategic partner in global clinical development operations, driving workforce planning, budget management, and continuous improvement initiatives. Collaborate with leadership to enhance...
Yesterday
Senior Manager, Clinical Trial Disclosure & Transparency
$132K - $199K *
Join a team that's committed to transparency in clinical trials, ensuring compliance with global disclosure regulations. This role blends operational and strategic tasks, fostering collaboration and q...
2 weeks ago
Senior Technical Officer, Emergency Response Analyst (Technical Officer III)
$86K - $116K *
Champion data-driven emergency response initiatives by leading analytics, ensuring quality assurance, and collaborating with global teams to enhance decision-making and program effectiveness in infect...
2 weeks ago
Physical Therapist | Physical Therapist | Shift 5x8 Days
$82K *
Provide skilled physical therapy services, evaluating patients and developing tailored treatment plans to restore function and mobility while ensuring compliance with regulations and collaborating wit...
Today
$153K - $290K *
Transform drug discovery by leading a dynamic team in medicinal chemistry, driving innovative small-molecule candidates from concept to IND-ready status while fostering collaboration across a global n...
3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.