Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Principal Product Manager, Member Experience
$200K - $230K *
Champion a transformative member software experience, guiding strategy and design across the care journey. Leverage data and user insights to drive impactful solutions in a complex healthcare landscap...
2 weeks ago
DIRECTOR, HELP DESK (EPIC Experience Strongly Preferred)
$149K - $299K *
Champion exceptional service delivery by leading Help Desk operations, ensuring high-quality support for members and stakeholders. Drive continuous improvement, operational excellence, and effective i...
1 week ago
$72K - $107K *
Join a team that's dedicated to enhancing resident development through effective program management, collaboration with clinical leaders, and innovative professional development sessions to ensure a s...
Today
$138K - $191K *
Shape the future of legal operations by managing complex investigations and litigation. Provide expert legal counsel, mitigate risk, and partner with stakeholders to communicate complex issues effecti...
Reposted 2 days ago
Auditor Clinical Validation Outpatient Specialty Clinical
$95K *
Advance your career by auditing outpatient and specialty claims, ensuring coding accuracy and compliance. Leverage your clinical and coding expertise to enhance audit processes and contribute to quali...
4 weeks ago
Director, Optimization Analyst
$88K - $140K *
Drive the development of predictive analytics models to enhance digital assessment operations, collaborating across teams to optimize decision-making and reduce costs while supporting strategic goals...
3 weeks ago
$160K - $200K *
Transform client relationships by driving business growth, securing profitable projects, and leveraging market access expertise. Lead teams to exceed expectations while identifying industry trends and...
Today
Applications Analyst-Clinical-Sr
$89K - $136K *
Innovate clinical application support to enhance patient care efficiency. Manage software upgrades, coordinate with IT teams, and lead projects while ensuring compliance and effective communication ac...
Today
Clinical Supply Chain Specialist
$85K - $100K *
Shape the future of clinical trials by managing supply chain activities, ensuring timely delivery of essential materials and maintaining regulatory compliance. Collaborate with diverse teams to enhanc...
1 month ago
Clinical Applications Support Specialist
$90K - $105K *
Optimize healthcare support by serving as the primary contact for clinical application issues. Collaborate with clinicians and IT teams to troubleshoot, educate, and resolve technical challenges, ensu...
3 weeks ago
In-Home Traveler Physician Full Time - DC
$174K - $374K *
Engage with patients in their homes to conduct health evaluations, build relationships, and bridge care gaps. This role demands extensive travel and flexibility to provide personalized care and diagno...
4 weeks ago
Account Executive Healthcare Customer Base
$100K - $120K *
Drive enterprise-level revenue growth by building relationships with healthcare executives, identifying strategic opportunities, and delivering tailored solutions to meet sales goals in a dynamic heal...
Yesterday
$250K - $300K *
Join a dedicated team to assess, diagnose, and treat patients, ensuring quality care and health education. Collaborate with healthcare professionals to enhance patient outcomes and maintain accurate m...
Yesterday
Associate Director, Virtual Health
$115K - $125K *
Drive the development and management of virtual health services, enhancing operational excellence and patient experience while scaling innovative care models across the organization. Lead strategic in...
Yesterday
$75K - $110K *
Optimize the claims resolution process for commercial property and casualty claims. Collaborate with internal teams and stakeholders to enhance claims handling efficiency and effective communication...
Reposted 1 week ago
Regional Sales Director - Richmond
$180K - $215K *
Lead the charge in driving regional sales success through strategic execution, team leadership, and cross-functional collaboration. Foster strong customer relationships and ensure alignment with corpo...
1 week ago
$103K - $128K *
Join us to lead product strategy and development, driving innovation and performance in healthcare solutions. Collaborate cross-functionally to align business needs with customer expectations and ensu...
3 weeks ago
Endpoint Engineer I (JAMF & Mac Experience required)
$80K - $100K *
Take ownership of complex desktop and mobile device support, ensuring high customer satisfaction. Administer enterprise management platforms and collaborate with teams to deliver effective technology...
1 week ago
Endpoint Engineer I (JAMF & Mac Experience required)
$80K - $100K *
Transform endpoint management by leading complex support initiatives, ensuring seamless service delivery across diverse environments. Collaborate with teams to enhance user experience and optimize tec...
1 week ago
Senior Clinical Research Associate, Northwestern regions, USA
$95K - $115K *
Elevate clinical research by monitoring trials, ensuring compliance with protocols and regulations. Collaborate with investigators to achieve study goals in dermatology and rheumatology, while working...
Yesterday
Internal Medicine or Family Medicine Physician
$241K - $337K *
Transform your career with a flexible role in primary care, serving a diverse patient population. Collaborate with a dedicated team in a supportive environment, offering both part-time and full-time o...
3 weeks ago
Hemostasis Sales Specialist - Atlanta / Charlotte Region
$99K - $136K *
Champion strategic growth in Hemostasis solutions by leading complex sales cycles, cultivating executive relationships, and driving market share expansion through innovative automation and informatics...
2 weeks ago
$176K - $230K *
Lead the charge in transforming healthcare through data-driven solutions. As a Senior Data Scientist, you'll spearhead projects that enhance patient outcomes, leveraging your expertise to align data s...
4 weeks ago
$130K - $160K *
Drive the development of LLM-based agents, ensuring robust production systems, effective evaluation, and seamless integration with company data while maintaining security and operational excellence ac...
3 weeks ago
Project Manager - Medical Communications
$80K - $95K *
Advance your career by managing diverse medical communications projects, ensuring timely delivery and client satisfaction while leading multidisciplinary teams and maintaining strong relationships wit...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.