Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Case Manager - Healthcare Appeals & Patient Access Advocate
$83K - $112K *
Partner with us to navigate complex patient cases and ensure seamless access to care. Utilize critical thinking and communication skills to manage authorizations and appeals, collaborating with divers...
Reposted 5 days ago
$100K - $120K *
Elevate clinical research by assisting with study design, medical monitoring, and compliance to ensure effective execution of clinical trials and contribute positively to patient outcomes in alignment...
Reposted 3 weeks ago
Staff Nurse Practitioner, Primary Care
$127K *
Contribute to transforming virtual primary care by delivering exceptional patient assessments, treatment plans, and ongoing support. Collaborate with healthcare teams while leveraging technology to en...
Reposted 3 weeks ago
$142K - $168K *
Transform client experiences by leveraging deep expertise in healthcare solutions. Lead strategic initiatives, enhance client relationships, and drive impactful outcomes for high-value accounts throug...
1 week ago
$210K - $260K *
Join a fast-paced team of medical professionals to evaluate and enhance service appropriateness through evidence-based guidelines, impacting quality patient outcomes across multiple specialties while...
Reposted 3 weeks ago
Physician, OB/GYN - Telemedicine Opportunity - DrHouse
$210K *
Unlock potential by delivering high-quality virtual care as a board-certified OB/GYN. Manage diverse clinical cases through telehealth, ensuring patient-centered treatment while enjoying a flexible sc...
2 days ago
Physician, OB/GYN - Telemedicine Opportunity - DrHouse
$210K *
Shape the future of telehealth by delivering compassionate, patient-centered care. Join a dynamic team of board-certified OB/GYN physicians providing virtual consultations across South Dakota, balanci...
2 days ago
Clinical Success Manager, Dosimetrist
$135K - $155K *
Join a team that's dedicated to enhancing clinical workflows in Radiation Oncology. As a Clinical Success Manager, you'll train clinics, solve problems, and foster relationships to ensure customer sat...
1 week ago
Medical Advocacy & Medical Education Director
$203K - $253K *
Strategize and lead patient advocacy and medical education initiatives, fostering collaboration with stakeholders to enhance patient engagement and inform Medical Affairs strategies. Drive impactful i...
6 days ago
Clinical Applications Specialist - X-Ray
$92K - $138K *
Deliver clinical expertise and training support for XR products, enhancing customer experience and operational efficiency. Collaborate with sales and clinical teams to drive education initiatives and...
Yesterday
$90K - $110K *
Accelerate program implementation and stakeholder engagement in pharmaceutical market access. Oversee daily operations, client relations, and staff management while ensuring adherence to budgets and p...
Reposted 3 weeks ago
Diagnosis-Related Group (DRG) Auditor III
$73K - $98K *
Join a team that's dedicated to excellence in DRG auditing. Leverage your expertise in MS-DRG and APR-DRG coding to ensure accuracy and compliance while working remotely. Enjoy a collaborative environ...
Today
Associate Director, Clinical Operations
$130K - $160K *
Oversee the operational planning and execution of clinical trials, ensuring compliance with regulatory standards while managing cross-functional teams to meet project timelines, budgets, and quality o...
2 weeks ago
$210K - $250K *
Deliver comprehensive case reviews and clinical guidance, ensuring regulatory compliance and optimal patient outcomes. Collaborate with healthcare teams across multiple states to enhance service quali...
3 weeks ago
$140K - $190K *
Unlock your potential by engaging key Gastroenterology stakeholders, driving product utilization, and exceeding sales goals through strategic collaboration and compliance in a dynamic healthcare envir...
4 weeks ago
$90K - $110K *
Analyze healthcare data to enhance clinical insights and improve medication use. Collaborate with cross-functional teams to develop analytics tools and real-world evidence studies, driving better heal...
6 days ago
Senior Director, Clinical Diagnostics and Precision Medicine
$242K - $403K *
Lead global companion diagnostics strategy, integrating diagnostic plans with clinical development and regulatory objectives. Drive execution across therapeutic programs, ensuring alignment with patie...
2 weeks ago
EHR Applications Analyst II, Claims
$70K - $105K *
Collaborate with cross-functional teams to enhance EHR workflows, improve operations, and optimize patient care through effective configuration and analysis of Professional Billing Claims applications...
1 week ago
$95K - $130K *
Lead the charge in backlog management and agile ceremonies, translating stakeholder needs into prioritized tasks. Collaborate across squads to ensure delivery quality and stakeholder satisfaction whil...
1 week ago
$110K - $130K *
Take ownership of corporate governance and entity management, ensuring compliance and efficiency across multiple subsidiaries. Support M&A and financing activities while maintaining a clean corporate...
3 weeks ago
Director, Clinical Pharmacology
$189K - $246K *
Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...
Today
Senior Director Government Programs
$154K - $196K *
Unlock potential by leading strategic government programs, managing P&L, and driving operational excellence. Oversee contract delivery, mentor staff, and foster client relationships to ensure growth a...
3 weeks ago
Director of Clinical Operations, Strategy, and Innovation
$182K - $247K *
Drive innovative clinical operations to enhance member care and outcomes. Collaborate across teams to implement strategies, optimize processes, and scale programs, ensuring seamless coordination and e...
Today
Associate Medical Director (RadScience)
$110K - $130K *
Join a dynamic team to lead the creation of impactful scientific content, enhancing medical education and patient outcomes. Collaborate cross-functionally, mentor writers, and drive excellence in heal...
1 week ago
Program Specialist, Care Management
$74K - $119K *
Transform healthcare delivery by coordinating strategic programs that enhance clinical and operational excellence. Collaborate with diverse teams to implement innovative solutions, ensuring compliance...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.