Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
National Account Director - Market Access & Payer Strategy
$175K - $185K *
Champion strategic payer engagement to enhance access and reimbursement across a national portfolio. Drive medical policy influence and build relationships with key stakeholders to expand coverage and...
3 weeks ago
Sr. Advisor, Molecular Pharmacology - Neuroscience
$129K - $231K *
Reimagine drug discovery as you lead molecular pharmacology efforts in neuroscience. Collaborate across teams to develop strategies, interpret data, and advance innovative therapies for sleep-wake dis...
Reposted 3 days ago
Senior Director, Global Medical Affairs
$177K - $338K *
Innovate the global medical strategy for a leading drug program. Drive launch readiness, evidence generation, and cross-functional partnerships while serving as the primary medical voice in product li...
Reposted 2 weeks ago
$80K - $95K *
Transform patient access by optimizing Epic Cadence workflows. Collaborate with clinical teams to enhance scheduling efficiency and support system improvements, ensuring seamless operations and superi...
2 days ago
Regulatory and Legal Operations Manager
$110K - $130K *
Optimize regulatory compliance and legal operations in healthcare. Collaborate with cross-functional teams to ensure adherence to industry standards while driving efficiency and effectiveness in legal...
Yesterday
Director, Head of Patient Recruitment and Retention, Americas
$171K - $231K *
Drive innovative patient recruitment strategies to enhance clinical trial enrollment and retention. Collaborate with cross-functional teams to implement data-driven approaches, optimize patient engage...
Reposted 4 weeks ago
Director - Product Management, LATAM
$163K - $297K *
Join a dynamic team to shape the future of digital consumer experiences in LATAM. Lead product strategy and execution for innovative e-commerce solutions, driving customer satisfaction and loyalty whi...
6 days ago
$92K - $110K *
Deliver strategic leadership and operational oversight to enhance decision-making processes within the Veterans Health Administration's EHRM, ensuring effective collaboration and communication across...
2 weeks ago
$110K - $130K *
Transform early phase clinical trials by leading design, execution, and oversight. Collaborate with cross-functional teams to ensure compliance and data integrity while managing project performance an...
4 weeks ago
Senior Director, Patient Reported Outcomes
$222K - $292K *
Elevate patient outcomes by leading global evidence strategies that showcase the value of therapies. Collaborate across functions to drive research programs, influence decision-making, and ensure scie...
3 weeks ago
$136K - $187K *
Lead patient education and support initiatives for individuals affected by generalized Myasthenia Gravis. Collaborate with caregivers and healthcare teams to enhance treatment coordination and empower...
6 days ago
$120K - $145K *
Unlock potential by driving commercial growth strategies for a product family. Collaborate across teams to translate market insights into actionable plans that enhance revenue, profitability, and cust...
Today
Medical Director - Critical Care
$300K - $309K *
Transform patient care by leading medical strategy and clinical innovation. As a vital member of the team, you'll guide product development and trial execution while engaging with key stakeholders to...
Reposted 3 weeks ago
Sr. Talent Acquisition Partner
$100K - $120K *
Shape the future of executive recruitment by leading strategic sourcing, engaging high-level candidates, and collaborating with a dedicated team to uncover top talent. This role offers growth opportun...
Reposted 2 weeks ago
$110K - $130K *
Join a team that's dedicated to creating impactful medical education content for healthcare providers and patients. Collaborate closely with scientific and account teams to deliver high-quality materi...
Reposted yesterday
Vice President of Product Management
$235K - $265K *
Champion product innovation by leading a dynamic team to define strategy, drive decisions, and ensure successful launches that align with company growth and customer needs in the health technology sec...
2 weeks ago
$225K - $265K *
Shape the future of oncology by leading clinical studies in early-phase development. Collaborate with multidisciplinary teams to drive innovative therapies and ensure high-quality execution of clinica...
1 week ago
$168K - $231K *
Join a dynamic team to lead Nurse Case Managers, enhancing patient support and education throughout treatment journeys while ensuring compliance and quality in case management processes...
6 days ago
$125K - $150K *
Pioneer in radiology innovation by enhancing clinical value and technology. Join a forward-thinking team that prioritizes high-quality patient care while driving improvements in service and operationa...
Reposted 2 weeks ago
Data and AI Governance Specialist
$108K - $149K *
Advance the organization by establishing robust data and AI governance practices. Collaborate across teams to ensure compliance, integrity, and responsible usage of data and AI assets, supporting both...
Reposted 5 days ago
Senior Oncology Account Specialist Prostate Cancer Santa Monica, CA
$108K - $250K *
Join a team that's dedicated to enhancing patient care by promoting innovative oncology solutions. You'll engage with healthcare professionals, drive product awareness, and leverage insights to streng...
Reposted 1 week ago
Case Manager - Healthcare Appeals & Patient Access Advocate
$83K - $112K *
Partner with us to navigate complex patient cases and ensure seamless access to care. Utilize critical thinking and communication skills to manage authorizations and appeals, collaborating with divers...
Reposted 5 days ago
$100K - $120K *
Elevate clinical research by assisting with study design, medical monitoring, and compliance to ensure effective execution of clinical trials and contribute positively to patient outcomes in alignment...
Reposted 3 weeks ago
Staff Nurse Practitioner, Primary Care
$127K *
Contribute to transforming virtual primary care by delivering exceptional patient assessments, treatment plans, and ongoing support. Collaborate with healthcare teams while leveraging technology to en...
Reposted 3 weeks ago
$142K - $168K *
Transform client experiences by leveraging deep expertise in healthcare solutions. Lead strategic initiatives, enhance client relationships, and drive impactful outcomes for high-value accounts throug...
6 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.