Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Average Salary: $114,696
$67K - $102K *
Champion compliance and quality assurance in GMP cellular product manufacturing. Collaborate with teams to ensure adherence to FDA regulations and FACT standards, driving process improvements and supp...
Reposted yesterday
Manager, Respiratory Therapy - Pediatrics
$88K - $105K *
Elevate patient care by leading clinical operations, ensuring compliance, and fostering team excellence in cardiopulmonary services while driving strategic improvements to enhance service quality and...
Reposted yesterday
$61K - $101K *
Unlock your potential by managing complex clinical research studies. Collaborate with multidisciplinary teams to ensure compliance, data integrity, and participant engagement while driving innovative...
Reposted yesterday
Sr Analyst, IT - SAP HR Developer
$95K - $115K *
Champion innovative SAP HR solutions by analyzing processes and developing high-performing applications. Collaborate with stakeholders to enhance technology and drive efficiency in HR systems, ensurin...
Reposted yesterday
Nurse Manager, Operations (NMO) - Cardiology & Pulmonary Clinic
$90K - $105K *
Join a team that's dedicated to advancing health through effective management and delivery of patient care in a dynamic clinical environment. Embrace a role that champions staff collaboration and opti...
Reposted yesterday
$95K - $115K *
Innovate enhanced analytical solutions that drive business value by transforming complex requests into actionable strategies and stakeholder alignment, ensuring effective collaboration across technica...
Reposted yesterday
Nurse Practitioner or Physician Assistant-Endocrinology
$95K - $115K *
Join a team that's dedicated to providing high-quality care to endocrine patients in a collaborative environment. You’ll assess, diagnose, and treat patients, working closely with healthcare professio...
Reposted yesterday
Director of Healthcare Accessibility and Accommodation
$63K - $109K *
Shape the future of healthcare accessibility by guiding compliance, enhancing patient services, and fostering inclusive environments in a dynamic academic health system...
Reposted yesterday
Nurse Practitioner/Physician Assistant: Spine Independent Clinic - Wake County
$95K - $115K *
Transform patient care by providing direct support in neurosurgery, collaborating with physicians to evaluate and manage spine patients. Engage in outpatient services, ensuring continuity of care whil...
Reposted yesterday
Nurse Practitioner/Physician Assistant: Duke Neurosurgery - Complex Spine
$95K - $115K *
Grow your career with a dynamic role providing direct patient care in neurosurgery. Collaborate with physicians to manage complex spinal disorders, ensuring quality treatment and patient progress in b...
Reposted yesterday
DIRECTOR OF SECURITY ENGINEERING
$180K - $200K *
Reimagine security engineering leadership by guiding strategic initiatives across cloud and infrastructure security, enhancing detection engineering, and fostering collaboration to protect a multi-clo...
Reposted yesterday
Management Engineer - Business Optimization
$80K - $95K *
Elevate workforce efficiency through advanced analytics, staffing optimization, and operational support. Collaborate with leaders to develop data-driven solutions that enhance labor stewardship and im...
Yesterday
SENIOR VICE PRESIDENT OF FINANCE - REMOTE
$240K - $270K *
Elevate financial strategy and performance across diverse, rapidly scaling operations. Lead as a trusted advisor, driving growth and operational excellence while building a high-performing finance org...
Yesterday
$110K - $130K *
Champion strategic sourcing initiatives across diverse categories, leading a high-performing team to drive measurable value. Foster partnerships, negotiate with suppliers, and implement innovative sol...
Reposted yesterday
SENIOR VICE PRESIDENT OF FINANCE - REMOTE
$240K - $270K *
Join a team that's shaping the future of finance in a rapidly scaling environment. Lead strategic financial initiatives, drive performance management, and partner with executives to enhance growth acr...
Yesterday
Finance Market Manager Great Lakes- VCFS
$105K - $182K *
Unlock your potential by driving sales and customer satisfaction in the Great Lakes market. Build strong relationships with retailers while achieving measurable targets and leading initiatives to enha...
Yesterday
Aviation Safety Inspector - POI
$95K - $115K *
Champion aviation safety by overseeing compliance and inspection duties for air carriers. Utilize advanced technical knowledge to ensure regulatory adherence and risk management in a dynamic aviation...
Yesterday
Family Nurse Practitioner or Physician Assistant - 4 days in clinic, 1 day remote
$127K - $136K *
Elevate patient care by managing diverse needs in a collaborative environment. Conduct in-office and tele-health visits while engaging in continuous learning and utilizing your clinical expertise to e...
Yesterday
Family Nurse Practitioner or Physician Assistant - 4 days in clinic, 1 day remote
$127K - $136K *
Join a team dedicated to transforming healthcare delivery by managing diverse patient needs, conducting in-office and tele-health visits, and collaborating with clinical teams to provide high-quality...
Yesterday
$88K - $155K *
Empower clients by leading strategic sourcing and contracting initiatives that drive efficiency and value. Utilize negotiation expertise to manage complex contracts and collaborate with legal teams, e...
Yesterday
SLP Speech Pathologist Home Health
$70K - $106K *
Advance patient care by providing in-home evaluations and treatments for speech, language, and swallowing disorders. Collaborate with patients and interdisciplinary teams to enhance communication and...
Yesterday
Account Executive, Enterprise Suite - Corporate
$124K - $171K *
Champion the future of enterprise sales by driving top-down solutions into global enterprises. Leverage AI and LLM technologies to enhance client insights and foster relationships across all organizat...
Yesterday
Manager, Clinical Stewardship Operations (RN)
$150K - $165K *
Build and manage clinical stewardship operations, driving client success through effective program implementation and cross-functional collaboration. Leverage clinical expertise to enhance client rela...
Yesterday
$110K - $135K *
Join a team that's redefining vacation rental marketing by crafting compelling ads and landing pages. Leverage your design expertise to drive owner acquisition through innovative, data-driven creative...
Yesterday
Pacific Northwest Regional Sales Manager- Aerospace & Defense
$170K - $200K *
Elevate your career by driving OEM sales in the Aerospace & Defense sectors. Lead strategic initiatives, cultivate new business, and enhance market presence across the Pacific Northwest, partnering wi...
Reposted yesterday
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.