Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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1,000+

Jobs in North Carolina

Average Salary in USD

Average Salary: $114,788

Sort By: Relevance

$200K - $265K *

Drive enterprise data strategy and governance, leading a high-performing team to enhance data capabilities, ensure compliance, and foster a data-driven culture that supports strategic business objecti...

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$118K - $142K *

Engage in comprehensive site monitoring and management for clinical trials, ensuring adherence to protocols and regulatory standards while providing high-quality care and support to study participants...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$317K - $371K *

Deliver innovative solutions in defense sales, expanding Air Force accounts while leveraging extensive industry knowledge and strategic relationships to meet client needs and drive revenue growth...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$123K - $145K *

Optimize product launches by collaborating cross-functionally to ensure timely delivery and high quality. Leverage engineering expertise to manage complex programs, drive continuous improvement, and e...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$116K - $149K *

Manage strategic growth initiatives for digital solutions in commercial markets. Collaborate with cross-functional teams to drive customer adoption, enhance operational performance, and achieve revenu...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$162K - $292K *

Join a team that's redefining identity operations by leading a 24/7 team to enhance access management strategies. You'll shape the vision, drive process innovation, and foster talent in a collaborativ...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$198K - $298K *

Lead the charge in shaping the AMER Revenue Operations strategy, driving operational excellence and predictable outcomes. Collaborate with executive leadership to optimize sales processes and build a...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Enterprise Technology

$95K - $115K *

Join us to facilitate software design, coding, and testing while enhancing system reliability. Collaborate with cross-functional teams to deliver high-quality solutions and support user training for s...

Today

  •   Less than 5 years exp.  •   Information Technology

$160K - $220K *

Champion the design and architecture of data systems, driving innovation and collaboration across teams to enhance user experiences and optimize data management for MyFitnessPal's ecosystem...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$97K - $120K *

Champion the development of innovative software solutions, collaborating with cross-functional teams to design, implement, and optimize applications that drive business success while mentoring junior...

Today

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Transform client relationships by driving retention and growth through strategic insights and data analysis. Lead negotiations with complex clients, ensuring profitable partnerships while collaboratin...

North Carolina, USRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Transform customer experiences by driving satisfaction and growth through strategic partnerships. Leverage your L&D expertise to enhance client engagement and ensure program success while collaboratin...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $110K *

Elevate your career by leading impactful fundraising communications and events. Drive donor engagement through compelling storytelling and strategic initiatives while managing a diverse portfolio in a...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$180K - $200K *

Transform our data landscape by leading the end-to-end data platform, modernizing architecture, and empowering analytics teams to deliver trusted insights across the organization. Drive innovation wit...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Hospitality & Recreation

$130K - $160K *

Transform the user experience and operational workflows in a complex two-sided marketplace. Lead product initiatives that enhance clinician and district interactions, streamline processes, and drive i...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$175K - $236K *

Champion quality excellence by leading a dynamic team to enhance compliance and drive continuous improvement in clinical development. Collaborate across functions to ensure regulatory readiness and de...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$197K - $328K *

Shape the future of pharmacy network operations by leading a team of attorneys, providing strategic legal counsel on regulatory, operational, and transactional matters within the PBM landscape, while...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Healthcare

$148K - $208K *

Optimize business planning and financial analysis for Americas Sales, driving strategic insights and operational excellence through advanced modeling, reporting, and AI-enabled process improvements to...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$110K - $150K *

Transform student engagement by developing impactful marketing campaigns and community initiatives across partner campuses. Drive enrollment and retention through strategic partnerships, innovative ou...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$194K - $242K *

Unlock potential by leading product marketing strategies in GLP-1 and cardiometabolic health. Collaborate with cross-functional teams to enhance buyer clarity and sales effectiveness, while coaching a...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Empower aseptic manufacturing excellence by leading training initiatives, ensuring compliance, and driving continuous improvement. Collaborate across teams to enhance aseptic practices and maintain hi...

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead cloud architecture and platform engineering, balancing strategic vision with hands-on technical execution. Drive team growth, ensure compliance, and enhance infrastructure for secure healthcare s...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Join us to drive growth in enterprise accounts, owning the full sales cycle from prospecting to closing. Collaborate with a dynamic team to convert leads into revenue while leveraging market insights...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$114K - $186K *

Drive strategic enterprise growth by guiding large organizations through their DevSecOps transformation, ensuring successful adoption and long-term value from GitLab's AI-powered platform while managi...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$168K - $226K *

Empower healthcare delivery by providing comprehensive primary care services, managing diverse patient needs, and engaging in quality improvement initiatives while ensuring optimal patient outcomes an...

Today

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.