Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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1,000+

Jobs in North Carolina

Average Salary in USD

Average Salary: $114,696

Sort By: Relevance

$220K - $287K *

Manage construction projects by planning, organizing, and supervising teams to ensure quality, compliance, and budget adherence while driving operational excellence and safety standards...

Yesterday

  •   Less than 5 years exp.  •   Staffing

$90K - $153K *

Drive the design and development of enterprise applications as a Senior Software Engineer, leading full stack solutions in a collaborative Agile environment. Partner with cross-functional teams to tac...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$134K - $241K *

Elevate your career by leading cybersecurity initiatives across California and the West Coast. Drive customer engagement, enhance security compliance, and support critical infrastructure sectors while...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$145K - $185K *

Transform account-based marketing strategies into impactful campaigns that drive pipeline growth and revenue. Lead integrated initiatives across multiple channels, ensuring alignment with sales and ma...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Champion data innovation by leading a team to enhance enterprise data quality, governance, and analytics. Drive strategic initiatives and collaborate with cross-functional teams to align data products...

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$210K - $250K *

Lead the charge in providing comprehensive care for chronic respiratory diseases, utilizing your expertise in pulmonology to enhance patient outcomes and manage complex cases effectively...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$88K - $105K *

Drive your career forward by leading SEO strategy and optimization efforts. Collaborate across teams to enhance digital visibility, user engagement, and business performance through data-driven insigh...

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Transform enterprise data management by leading a team to enhance data quality, governance, and analytics. Drive strategic initiatives and collaborate with cross-functional teams to deliver scalable d...

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$168K - $228K *

Transform global GxP Change Management processes by leading strategy, governance, and continuous improvement initiatives across the product lifecycle, ensuring effective risk-based changes and collabo...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$138K - $188K *

Lead global trade compliance initiatives, ensuring adherence to regulations across multiple jurisdictions. Drive strategic programs for import/export operations, risk management, and partner governanc...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Elevate patient care by independently managing acute and chronic conditions, collaborating with interdisciplinary teams, and implementing evidence-based practices to enhance health outcomes in a dynam...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$210K - $250K *

Join a team that's dedicated to providing expert consultation in Hematology and Oncology, managing patient care in both inpatient and outpatient settings while guiding advanced practice providers and...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Advance the future of mental health by providing expert psychological assessments, evaluations, and treatments. Collaborate with interdisciplinary teams to enhance patient care and manage complex clin...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Engineer critical electrical and mechanical systems for data centers, leading field support, troubleshooting, and reliability improvements while developing operational standards and mentoring teams to...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in enhancing health, safety, and environmental performance across data center construction projects. Collaborate with teams to ensure compliance with OSHA standards and drive continuou...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Pioneer innovative crop genetic engineering by leading a team of scientists in transgenic event generation, enhancing biotech capabilities, and driving efficient product development in a dynamic resea...

Yesterday

  •   5 - 7 years exp.  •   Food & Beverages

$110K - $130K *

Innovate in cancer research by designing and deploying advanced AI and machine learning solutions. Collaborate with cross-functional teams to develop multimodal models integrating diverse clinical dat...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$185K - $235K *

Optimize family access and reimbursement strategies in a hybrid role, collaborating with healthcare providers and families. Leverage your expertise to navigate complex pathways, ensuring compliance an...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Join a dynamic team to drive product strategy for high-performance data processing and analytics, shaping modern solutions that integrate seamlessly with cloud-native environments and enhancing the wa...

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Transform product strategy for high-performance data processing. Collaborate with cross-functional teams to drive innovation in cloud-native environments, ensuring seamless integration and exceptional...

Cary, NCRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$185K - $235K *

Join a team that's redefining access in healthcare by leading reimbursement strategies and supporting families in navigating complex pathways for Skeletal Dysplasia therapies. Drive impactful change t...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$215K - $355K *

Develop and lead advanced IAM engineering initiatives for multi-cloud environments. Shape the organization's cloud-agnostic identity strategy while fostering teams focused on innovation, security, and...

Reposted yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Lead the charge in delivering expert appraisal services for commercial real estate, ensuring compliance and quality through vendor management, training, and performance evaluation while collaborating...

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Unlock potential by leading product marketing strategies for developer-facing solutions. Collaborate across teams to enhance messaging, drive customer engagement, and ensure successful deployments, al...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$95K - $125K *

Transform client relations through innovative sales strategies while achieving consistent targets in a dynamic market. Drive growth by effectively managing existing partnerships and exploring new oppo...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.