Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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Director, Program Management Jobs in North Carolina

Sort By: Relevance

$162K - $243K *

Join a team that's dedicated to advancing clinical trials through strategic oversight and collaboration. Lead project management efforts globally, ensuring quality, cost, and timeline objectives are m...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $170K *

Execute complex, cross-functional initiatives while navigating ambiguity and redefining operational models. Your strategic insights and leadership will propel projects to success and enhance overall o...

United StatesRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Champion the successful delivery of customer projects through all phases, ensuring alignment with business goals by coordinating teams and resources while managing risks and transacting key communicat...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Transform your career by leading cross-functional teams to drive drug development strategies. Collaborate with key stakeholders to ensure successful execution of integrated plans, manage risks, and de...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $180K *

Lead the charge in driving agile execution across product and engineering teams, managing digital product launches and enhancing client value through innovative solutions. Collaborate cross-functional...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$127K - $150K *

Take ownership of program management governance, ensuring operational excellence and strategic alignment across corporate real estate projects. Collaborate with stakeholders to enhance project deliver...

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$127K - $150K *

Elevate your career by leading governance and operational control in corporate real estate. Collaborate with key stakeholders to enhance project management delivery and ensure compliance across critic...

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$125K - $150K *

Deliver strategic leadership for a centralized partner data management system, ensuring alignment with business priorities and enhancing user experience. Collaborate with cross-functional teams to dri...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$125K - $211K *

Join our dynamic team as you lead new product launches in hardware manufacturing. Oversee cross-functional collaborations, manage operational risks, and drive high-quality production strategies that s...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Lead the charge in managing cross-functional programs that enhance AI data quality and evaluation. Collaborate with diverse teams to translate product needs into actionable plans, ensuring efficient d...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Shape the future of enterprise-scale cybersecurity by leading vulnerability management initiatives. Drive program strategy, enhance client relationships, and mentor teams to achieve measurable risk re...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Lead the charge in optimizing project management processes for a VHA client team. Utilize your expertise to enhance strategic planning, decision-making, and execution while collaborating with senior s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$88K - $95K *

Drive operational excellence by leading projects across teams, enhancing efficiency, managing stakeholders, and ensuring timely delivery. Collaborate within a dynamic environment dedicated to improvin...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$128K - $214K *

Empower cross-functional teams to deliver complex technical programs, ensuring alignment with business goals. Lead planning, execution, and stakeholder communication while fostering a collaborative en...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $100K *

Transform software delivery by managing cross-functional teams, aligning sprints, and optimizing project timelines. Drive clarity in processes and foster collaboration to ensure successful product exe...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $230K *

Lead complex, multi-workstream technology programs, ensuring alignment across teams and delivering customer outcomes through strategic planning, execution, and governance. Drive program success by man...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $200K *

Lead the charge in optimizing top-of-funnel marketing operations, driving measurable pipeline growth through strategic planning, data governance, and team leadership. Collaborate with cross-functional...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$195K - $241K *

Partner with us to drive growth and adoption across a diverse product portfolio, managing strategic partnerships from design to launch. Collaborate cross-functionally to enhance relationships and ensu...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$97K - $121K *

Champion strategic initiatives by managing cross-functional teams, driving decision-making, and ensuring repeatable processes across the organization. Thrive in a dynamic environment while delivering...

2 days ago

  •   5 - 7 years exp.  •   Transportation

$162K - $228K *

Transform the Ad Tech landscape by leading cross-functional teams to ensure seamless delivery and execution of complex technology portfolios, driving strategic initiatives and fostering collaboration...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$162K - $243K *

Shape the future of clinical research by leading cross-functional teams to optimize project delivery, ensuring quality and compliance while managing resources and budgets effectively across global cli...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Lead the charge in shaping a new Technical Program Management team, guiding TPMs to deliver impactful results while fostering collaboration across Engineering and Product. Drive strategic planning and...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$102K - $154K *

Lead the charge in managing complex customer escalations, driving rapid resolutions and systemic improvements. Collaborate cross-functionally to enhance workflows and customer experiences while ensuri...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Champion enablement initiatives across Technical and Sales domains, partnering with experts to define and execute programs. Lead content development, delivery, and continuous improvement efforts to en...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Drive the planning and execution of complex therapeutic programs from discovery to clinic. Serve as a senior program management partner, ensuring successful execution and alignment across cross-functi...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.