Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$300K *

Unlock potential by leading national consultant relations, driving strategy, and managing a team to enhance employer opportunities. Engage with key consulting firms while fostering relationships that...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$100K *

Analyze market trends and manage high-performing sales teams to enhance revenue. Contribute to strategic initiatives aimed at driving sales growth while fostering a competitive and productive team cul...

Reposted yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $155K *

Lead content operations for a federal web services program, managing a team to ensure timely, accurate, and accessible communication. Drive strategic planning, oversee Drupal content management, and e...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $175K *

Unlock potential by driving advanced network solutions, providing technical leadership, and optimizing architecture for high performance and security in a global enterprise environment...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Business Services

$90K - $110K *

Champion growth by expanding dealership networks and driving financing adoption in the powersports industry. Build relationships, identify opportunities, and enhance dealer experiences through strateg...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $155K *

Transform data into actionable insights by leading research initiatives, collaborating with business leaders, and developing predictive models to drive strategic decisions and enhance product offering...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Drive AI transformations in manufacturing by collaborating with C-level executives to identify high-impact opportunities, build tailored solutions, and achieve measurable results in core operating pro...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's dedicated to managing investment advisory risks, collaborating across the organization to enhance risk management initiatives and support the Enterprise Risk Management framework. D...

Reposted yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $165K *

Lead the charge in optimizing bulk distribution services, managing barge supply chains, and ensuring operational excellence from stockpile management to delivery. Collaborate cross-functionally to enh...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Food & Beverages

$140K - $175K *

Unlock strategic program management oversight by analyzing cross-program activities, mitigating risks, and ensuring effective communication of technical progress to stakeholders. Drive mission outcome...

Reposted yesterday

  •   8 - 10 years exp.  •   Business Services

$125K - $150K *

Empower customer success by designing impactful journeys that drive retention and revenue. Lead cross-functional teams to create and optimize service blueprints, ensuring seamless customer experiences...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Transform taxpayer advocacy by leading a dedicated team to resolve complex cases, ensuring timely solutions and alignment with national priorities while fostering collaboration across IRS divisions...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$190K - $283K *

Drive impactful data analyses and innovative experiment design to enhance product strategies and optimize Ads Marketplace performance, collaborating with cross-functional teams in a flexible, hybrid w...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Lead the charge in optimizing our Adaptive Planning platform, ensuring accurate data management and seamless integrations. Collaborate with cross-functional teams to enhance reporting and streamline f...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$75K - $95K *

Elevate mobile app acquisition strategies by managing omni-channel paid media campaigns. Collaborate with clients to optimize performance, drive growth, and ensure seamless execution across platforms...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Media

$90K - $92K *

Join a dynamic team as you support project execution and management for USACE maintenance tasks. Collaborate with stakeholders, track performance metrics, and guide project teams to ensure successful...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$370K - $415K *

Unlock potential by leading Affirm's global legal strategy across Product, Regulatory, and Litigation teams. Collaborate with executives to drive innovation while managing complex legal risks in the c...

United StatesRemote

Yesterday

  •   15+ years exp.  •   Finance & Insurance

$83K - $140K *

Innovate financial strategies by partnering with R&D leaders to optimize costs, enhance reporting frameworks, and drive accurate forecasting in a dynamic environment. Your analytical skills will shape...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$172K - $233K *

Engage with healthcare leaders to advance scientific communication in bone health. This role involves collaboration, mentorship, and strategic support to enhance patient care and drive research initia...

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Shape the future of our organic social media presence by managing channels, coordinating campaigns, and leveraging analytics to enhance engagement and community growth across multiple platforms...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$85K - $118K *

Empower patient care by delivering dialysis treatments and collaborating with a dedicated team. Utilize your critical thinking skills in a fast-paced environment to ensure the safety and wellbeing of...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$118K - $141K *

Deliver engaging training and develop content for Altium Designer, leveraging your PCB design expertise. Collaborate with teams to enhance training quality and support customer adoption through effect...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Join a dynamic team to enhance Robotics Operations through innovative software solutions. Collaborate with cross-functional teams to identify needs, deliver impactful improvements, and maintain reliab...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Transportation

$125K - $145K *

Lead and optimize transportation operations, driving excellence through team development, P&L management, and strategic partnerships. Foster a safety-first culture while exceeding customer expectation...

2 days ago

  •   5 - 7 years exp.  •   Transportation

$80K - $95K *

Shape customer success by managing project timelines and expectations, fostering relationships, and ensuring accurate forecasting and billing. Drive operational excellence and continuous improvement t...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.