Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$110K - $130K *

Drive team success as you lead a dynamic paid advertising group, fostering growth and innovation. Oversee client accounts, ensuring high-quality execution and strategic insights while mentoring team m...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Drive the design and delivery of impactful IT training programs, collaborating with cross-functional teams to enhance employee skills and support technology initiatives across various learning levels...

Today

  •   Less than 5 years exp.  •   Real Estate & Construction

$150K - $200K *

Join us in a pivotal leadership role to enhance customer success initiatives, drive operational excellence, and build a high-performing team focused on customer engagement and retention strategies in...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Innovate your career by leading the strategy and creation of impactful B2B content across various formats. Collaborate with teams to enhance engagement and drive demand through high-quality, optimized...

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Reposted today

  •   5 - 7 years exp.  •   Energy & Utilities

$165K - $195K *

Accelerate the recruitment process for early-career talent, leading strategy and execution for cohort hiring. Collaborate across teams to ensure alignment and quality, while leveraging data and AI to...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $144K *

Transform client relationships and elevate service delivery by managing Building Automation System programs. Combine hands-on technical expertise with leadership to ensure high-quality support in crit...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Technical Services

$135K - $160K *

Empower your career by leading a dynamic team in strategic account management, driving product adoption, and maximizing growth for top-tier clients in the media and technology sectors. Shape the futur...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Shape the future of hotel technology by owning the end-to-end booking experience, bridging guest interactions and hotel-focused workflows to drive measurable business value through innovative solution...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Hospitality & Recreation

$108K - $149K *

Inspire growth by leading a regional sales team to achieve goals, enhancing customer experiences, and developing effective training programs while driving profitable revenue through strategic leadersh...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Accelerate healthcare outcomes by leading the Enhanced Care Management program. Oversee operations, drive strategic initiatives, and collaborate with teams to enhance patient care while ensuring compl...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$105K - $140K *

Grow your career with a dynamic sales role focused on Fortune 1000 clients. Drive new business, manage account strategies, and collaborate with teams to achieve sales success in a fast-paced, high-gro...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Consumer Technology

$130K - $155K *

Lead the charge in delivering high-quality cost management services for large-scale data center projects. Collaborate with clients and stakeholders to ensure project objectives are met throughout the...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead end-to-end client engagements for complex AI and digital projects, managing multiple implementations while ensuring timely delivery and exceeding client expectations. Collaborate with cross-funct...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $190K *

Lead global accounting functions, ensuring integrity and efficiency in financial processes. Supervise teams across multiple locations while enhancing reporting accuracy and compliance within a growing...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Join us to lead a dynamic engineering team, driving innovation and reliability in financial account data. Collaborate across functions, set technical direction, and empower your team to deliver impact...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$255K - $280K *

Elevate your career by leading the publication strategy for innovative medical research. Drive impactful scientific communications and collaborate with experts to enhance real-world evidence initiativ...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$217K - $303K *

Join a team that's building powerful tools for moderators, enhancing user experience through innovative backend solutions for one of the world's largest platforms. Drive technical strategy and lead en...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Media

$110K - $120K *

Transform customer experiences by leading complex implementations, aligning stakeholders, and ensuring successful technical deployments that drive meaningful business outcomes across multiple projects...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Elevate your career by becoming a product expert in CommunitySuite, guiding clients through complex solutions, delivering tailored demos, and ensuring seamless transitions from sales to implementation...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Drive excellence in medication management by preparing, dispensing, and evaluating drug therapies. Collaborate with healthcare teams to enhance patient outcomes and ensure safe medication practices in...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$180K - $215K *

Elevate regional sales performance by leading a high-performing team, executing launch strategies, and fostering customer relationships in a dynamic environment. Drive accountability and collaboration...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$190K *

Lead the design and evolution of backend systems, tackling complex challenges while collaborating with cross-functional teams to deliver reliable, scalable solutions that enhance user experience and d...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$200K - $230K *

Transform laboratory automation by leading the integration of intelligent workflows, AI, and interoperability standards to create scalable, innovative solutions that enhance scientific capabilities ac...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Unlock your potential by supporting complex customer needs through expert solution design and seamless sales transitions. Collaborate with teams to drive sales opportunities and enhance customer engag...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$148K - $175K *

Unlock potential by leading quantitative testing and monitoring for AI models in compliance, ensuring data quality and regulatory adherence while collaborating across teams to enhance financial crime...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.