Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$140K - $195K *

Transform your career by leading high-performing incident response teams, managing complex client engagements, and mentoring the next generation of cybersecurity experts while protecting organizations...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $160K *

Take ownership of technical consulting and integration for grid management systems, ensuring accuracy and operational usability within electric utility sectors. Drive solution delivery through system...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$138K - $161K *

Elevate your career by driving transformative supply chain solutions. Lead strategic account relationships, develop executive strategies, and create new business opportunities within a dynamic environ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $125K *

Advance your career by leading retail marketing operations to drive growth, enhance customer loyalty, and improve performance across multiple dealership locations. Collaborate with leaders while lever...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Transportation

$85K - $120K *

Join a dynamic team to develop innovative mobile solutions using React Native. Collaborate with cross-functional teams to enhance user experiences on iOS and Android, shaping the future of vehicle own...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Transportation

$85K - $100K *

Join a dynamic team as you drive data integrity and enhance client reporting through Addepar. Leverage your analytical skills and operations experience to support private investment processes and coll...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $200K *

Accelerate progress at a multinational level by driving the reward and global mobility agenda. Lead the design and governance of compensation structures, ensuring alignment with business needs while p...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$175K *

Shape the future of global telecommunications by leading strategy, architecture, and operations for voice and video infrastructure, ensuring reliable and cost-effective communication services aligned...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$150K - $170K *

Drive innovation as you lead AI-powered product design initiatives, collaborating with teams to create transformative user experiences. Shape the future of technology by designing functional, user-cen...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $280K *

Unlock the potential of innovative hardware solutions by leading a dynamic team of engineers. Drive product development, optimize resources, and ensure compliance while fostering collaboration across...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$200K - $300K *

Pioneer partner success by leading technical enablement for contact center solutions. Drive onboarding, co-selling support, and strategic architecture using Zendesk and AWS technologies to empower par...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Transform your career by bridging design and sales in a dynamic engineering role. Collaborate with clients and teams to deliver precise structural estimates and innovative solutions for complex constr...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$115K - $135K *

Shape the future of our Accounting Operations by leading a dynamic team, ensuring accuracy and efficiency in financial processes, and driving improvements through automation and AI integration...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$135K - $160K *

Champion a team of product managers to drive innovative software solutions. Shape product direction, enhance customer understanding, and elevate product quality while fostering leadership and collabor...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Shape the future of partner engagement by leading global programs that enhance value across the customer lifecycle. Collaborate with cross-functional teams to streamline processes, improve partner exp...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Transform health information management by leading a dedicated team, ensuring data integrity, compliance, and optimal operations across the organization while fostering staff development and collabora...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$105K - $160K *

Drive customer success by optimizing digital journeys and automating solutions. Collaborate cross-functionally to enhance user experiences while leveraging AI and coding skills to maintain and deploy...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Drive the development and integration of advanced nuclear energy systems by applying systems engineering methods to translate objectives into clear, verifiable requirements and solutions, while collab...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$116K - $160K *

Accelerate progress at driving strategic initiatives within Operations and Member Experience. Collaborate with cross-functional teams to deliver impactful solutions, enhance operational efficiency, an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$75K - $105K *

Partner with us to lead the implementation and optimization of a cloud-based ERP system, focusing on talent management processes across campuses and healthcare. Collaborate with stakeholders to enhanc...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$190K - $300K *

Champion scientific exchange and clinical research in Cardiovascular & Metabolism. Engage with medical leaders, enhance understanding of research goals, and gather insights to drive strategic initiati...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$175K - $190K *

Drive strategic ERP and Finance transformations by guiding clients through assessments, technology alignment, and Workday implementations. Leverage your expertise to shape visions, foster relationship...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$175K - $190K *

Champion strategic ERP and HCM transformations, guiding clients through assessments, technology alignment, and implementation execution to drive impactful change and enhance organizational readiness...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Transform your career by leading complex accounts, driving sales growth, and fostering multi-level relationships. Collaborate with teams to develop strategies and ensure customer success while managin...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $175K *

Lead the charge in architecting and managing robust cloud platforms, driving modernization efforts, and automating infrastructure solutions for large-scale enterprises. Collaborate with top engineers...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.