Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$145K - $150K *

Grow your career with a collaborative team focused on public health solutions. As a Senior Salesforce Developer, you'll leverage your expertise to enhance health department systems nationwide within a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$262K - $394K *

Accelerate progress at Clio Phones by leading the growth of a cloud-native VoIP platform for law firms. Own P&L, build operational plans, and drive market strategy while managing cross-functional team...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$105K - $163K *

Accelerate progress at the forefront of enterprise security solutions, driving revenue growth through strategic account management and collaboration with internal teams to enhance customer relationshi...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$145K - $195K *

Drive structural design excellence across diverse projects by leading the preparation of detailed construction drawings and calculations. Collaborate with teams to ensure high-quality designs and ment...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$115K - $130K *

Lead the charge in scaling our TikTok Shop and Trybe Program, overseeing P&L, creator strategies, and LIVE commerce. Drive growth through strategic planning and community engagement, ensuring high-per...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$180K - $215K *

Lead regional launch initiatives, driving sales performance and team success through strategic execution and strong customer engagement in a fast-paced environment...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$102K - $171K *

Drive impactful medical drug strategies by leveraging healthcare expertise and data. Collaborate with cross-functional teams to enhance client solutions and support product development, ensuring effec...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Innovate quantitative trading strategies by researching market behaviors, developing algorithms, and managing daily trading operations. Collaborate cross-functionally to enhance execution and optimize...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Elevate industry analysis by providing expert technical support, developing policies, and engaging with legislative matters. Collaborate with leadership to enhance training programs and ensure clarity...

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $164K *

Lead our cybersecurity and governance initiatives, enhancing security operations and risk management while driving compliance with CMMC 2.0 and ISO/IEC 27001 standards. Collaborate across teams to imp...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Unlock insights and drive performance as you analyze data, develop countermeasures, and execute strategies in the field. Collaborate with sales teams to enhance dealer activation and reduce churn, ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Drive partner success by providing expert technical guidance, leading complex implementations, and mentoring junior engineers. Collaborate cross-functionally to enhance product adoption and ensure opt...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$103K - $142K *

Transform workforce insights into actionable strategies by leveraging HR systems and analytics. Collaborate with cross-functional teams to enhance decision-making through compelling data visualization...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Lead the charge in advanced financial analysis and strategic sourcing initiatives, collaborating with cross-functional teams to drive insights and influence decision-making across multiple divisions a...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $150K *

Champion public safety operations across North America, leading program directors to ensure effective training, deployment, and customer satisfaction while aligning resources and operational prioritie...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$135K - $160K *

Shape the future of K-12 sales by leading a dynamic team of Account Executives. Drive performance through strategic planning, precise forecasting, and collaborative initiatives to achieve growth targe...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Lead the charge in transforming business needs into actionable data solutions. Collaborate with stakeholders to define requirements, prioritize backlogs, and deliver impactful data products that drive...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Transform healthcare by building relationships and educating professionals on innovative products. Collaborate with key opinion leaders and contribute to research initiatives while enhancing knowledge...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$144K - $200K *

Lead a national team of Key Account Leaders to drive sales in campus public safety, focusing on recruitment, coaching, and team performance. Shape strategies to enhance sales effectiveness and adapt t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Transform your career by driving customer success and technical solutions. Collaborate with cross-functional teams to enhance client relationships, identify growth opportunities, and ensure maximum va...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$144K - $200K *

Lead the charge in developing a high-performing sales team focused on public safety. Drive recruitment, coaching, and retention while ensuring team success through strategic deal management and AI int...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$110K - $130K *

Transform your career by leading impactful field marketing initiatives across diverse brands. Collaborate with teams to create memorable events that enhance brand awareness and drive measurable growth...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$159K - $188K *

Unlock potential by leveraging data to drive product decisions and enhance user engagement. Collaborate across teams to design experiments, develop predictive models, and influence product strategies...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$279K - $349K *

Drive the strategy and execution of dedicated infrastructure engineering, leading a high-performing team to enhance enterprise SaaS offerings, ensure compliance, and deliver exceptional customer exper...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$157K - $283K *

Lead the charge in driving business growth by developing strategic partnerships and innovative solutions for federal clients, while collaborating with cross-functional teams to deliver exceptional res...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.