Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$110K - $130K *

Grow your career with a dynamic design role focused on transforming complex supply chain systems into intuitive user experiences. Collaborate with teams to enhance operational efficiency and drive imp...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$89K - $111K *

Engage in strategic sales management and relationship growth, overseeing account development, promotional planning, and data analysis to maximize profitability and enhance partnerships with key retail...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Join the charge in shaping CoreView's Federal market presence by leading strategic field marketing initiatives, enhancing brand awareness, and driving lead generation campaigns to establish a robust p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $200K *

Elevate healthcare technology by owning mobile and web apps that enhance clinician workflows. Drive product direction, prioritize initiatives, and ensure patient safety while leveraging AI to improve...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$162K - $258K *

Drive the design and implementation of cutting-edge GenAI solutions, leading the development of LLM capabilities and ML pipelines to enhance insurance workflows and deliver impactful outcomes for cust...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Transform the infrastructure landscape by leading Site Reliability Engineering and platform architecture for global expansion, ensuring reliability, cost efficiency, and compliance across multiple ser...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $375K *

Elevate your career by owning the methodology and tooling for Code Archaeology. Lead large-scale architectural engagements, shape market perspectives, and drive innovation in enterprise software moder...

1 week ago

  •   11 - 15 years exp.  •   Business Services

$165K - $210K *

Drive the technical vision for complex systems, leading cross-team initiatives and enhancing engineering standards. Own reliability and scalability of core infrastructure while mentoring engineers and...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $134K *

Elevate compliance standards by conducting detailed FedRAMP assessments, analyzing technical artifacts, and collaborating with clients to ensure security controls are effectively implemented and docum...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$250K - $300K *

Transform the delivery of orthopedic care by leading a dedicated team, managing surgical procedures, and enhancing patient outcomes for veterans while upholding comprehensive healthcare standards and...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$106K - $114K *

Lead the charge in driving strategic partnerships, managing budgets, and optimizing performance. Collaborate cross-functionally to enhance partner success and deliver impactful training programs, ensu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$171K - $248K *

Lead a dynamic engineering team to enhance infrastructure and networking, driving user-focused product development while fostering collaboration and operational excellence across the organization...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$180K - $195K *

Advance academic excellence by leading institution-wide initiatives, enhancing student pathways, and driving enrollment growth. Collaborate with Deans and faculty to align academic strategies with mar...

1 week ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$150K - $200K *

Develop and maintain robust data pipelines and models, collaborating with cross-functional teams to enhance data practices and ensure quality. Drive modernization efforts in data engineering, optimizi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Drive client success by managing relationships, enhancing satisfaction, and identifying growth opportunities. Collaborate with internal teams to deliver exceptional service and exceed client expectati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Empower healthcare technology by enhancing clinical systems and integrations. Collaborate with IT and business stakeholders to optimize workflows, manage projects, and ensure system performance across...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$148K - $222K *

Drive clinical adoption and enhance partnerships by leading a high-performing Medical Science Liaison team. Collaborate with sales and medical teams to educate stakeholders, influence decision-making...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Explore the dynamic role of a Program Manager, overseeing end-to-end data collection programs. Drive operational excellence, client satisfaction, and strategic execution in a fast-paced environment, e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Lead the charge in transforming agency operations by ensuring seamless onboarding and mastery of our all-in-one AdTech platform, bridging technical capabilities with real-world execution for impactful...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Drive impactful manager research for Mutual Funds, SMAs, and ETFs, contributing to the management of $9 billion in client assets. Collaborate with investment professionals and leverage AI tools to enh...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $150K *

Elevate your career by leading product operations, enhancing processes, and driving AI adoption. Collaborate with cross-functional teams to optimize product delivery and analytics, ensuring seamless c...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$194K - $266K *

Lead the charge in driving commercial growth by securing high-value partnerships and expanding market presence. Mentor a dynamic team while executing strategic initiatives that enhance client relation...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Explore innovative solutions as a Senior Mobile Engineer, leading the design and architecture of mission-critical apps that empower our delivery fleet and operations teams, ensuring reliability and ef...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Transportation

$100K - $120K *

Empower quality assurance excellence by leading inspections across North America, ensuring critical infrastructure meets project standards. Collaborate with suppliers and teams to mitigate risks and d...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Lead the charge in architecting innovative geospatial solutions, guiding strategic investments, and aligning technology with business objectives to transform client operations and enhance program effi...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.