Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$80K - $95K *

Drive financial insights and reporting for North America, enhancing profitability and efficiency through data analysis and strategic forecasting. Collaborate with diverse teams to support informed dec...

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$210K - $249K *

Lead the vision and strategy for SRE across payments, driving reliability, automation, and incident management while scaling the function and fostering a culture of operational excellence and continuo...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$150K - $180K *

Lead a high-performance engineering team, driving strategy and innovation for Corporate Payments services while aligning technology with business goals. Foster collaboration and continuous improvement...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$167K - $366K *

Lead the charge in establishing strategic BPO partnerships globally, driving Zoom's disruptive CX platform into the outsourcing market. Own the full business development lifecycle, from prospecting to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$76K - $186K *

Drive resolution for complex porting escalations, mentoring specialists and enhancing processes. Engage with high-value customers and partners, ensuring clear communication and effective management of...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$96K - $207K *

Drive Treasury Management revenue by optimizing receivables solutions through collaboration with teams, leveraging technical expertise to enhance client cash application and working capital efficiency...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$112K *

Deliver comprehensive oversight of protection order processes, ensuring operational efficiency and legal compliance while managing staff and enhancing departmental functions in a dynamic court environ...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$108K - $122K *

Champion exceptional corporate events by leading strategy, design, and execution of high-impact experiences for clients and executives, ensuring alignment with business goals and delivering premium se...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$68K - $143K *

Analyze and reengineer business processes to enhance operational efficiency, collaborating with stakeholders to ensure alignment with strategic goals and regulatory requirements while supporting syste...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$68K - $143K *

Unlock innovative financial processes by driving transformation in logistics integration and optimizing resource allocation. Collaborate with diverse teams to enhance financial operations within the D...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$82K - $172K *

Champion eDiscovery project management by leading high-visibility initiatives for the DOJ. Collaborate with legal teams to ensure seamless project execution across all EDRM phases, delivering quality...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $158K *

Join a dynamic team to enhance cybersecurity by analyzing threats, developing intelligence reports, and collaborating with stakeholders to protect critical assets and improve incident response capabil...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$129K - $193K *

Join a dynamic team as a Subject Matter Expert, guiding mission planning solutions for USMC aviation. Collaborate with engineers and pilots to enhance operational capabilities and deliver impactful tr...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $120K *

Shape the future of Crop Protection & Chemicals by driving sales and fostering client relationships. Utilize strategic insights and collaboration to achieve targets and expand market presence while ma...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$148K - $201K *

Drive category strategy and supplier relationships to enhance Market Access, Pricing, and Health Economics. Collaborate with cross-functional teams to optimize procurement processes and improve operat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$78K - $126K *

Grow your career with a leading professional services firm, providing expert support in Sage Intacct. Engage with clients, troubleshoot issues, and enhance your technical skills in a collaborative, re...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$116K *

Drive impactful site activation strategies, collaborating with cross-functional teams to ensure timely delivery of clinical projects while enhancing communication and mitigating risks throughout the p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$116K *

Lead site activation efforts by coordinating with cross-functional teams to ensure timely and quality delivery of clinical projects. Drive strategic initiatives and mitigate risks while enhancing comm...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$234K - $322K *

Transform global revenue accounting and order-to-cash processes in a dynamic healthcare environment. Lead a high-performing team, ensuring compliance with U.S. GAAP and driving systems improvements fo...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $140K *

Join a dynamic team to enhance cybersecurity programs, engage with clients, and deliver strategic advisory services. Contribute to thought leadership while developing tailored initiatives to protect o...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $140K *

Empower organizations by leading incident response efforts, utilizing advanced forensic techniques to combat sophisticated cyber threats. Collaborate with a dynamic team to deliver impactful security...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $120K *

Shape the future of cybersecurity by analyzing North Korean threats and providing actionable intelligence. Collaborate with experts to uncover insights that drive strategic decisions and enhance secur...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$111K - $161K *

Transform the future of energy efficiency by leading a $200M facility upgrade project. Oversee construction, engage stakeholders, and ensure compliance with safety standards while managing resources a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$92K - $134K *

Join us to lead the charge in managing a $32M facility upgrade project, ensuring effective collaboration with teams and stakeholders while maintaining safety and quality standards throughout the const...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Transform your career by leveraging your underwriting expertise to mentor others, handle complex inquiries, and drive process improvements in personal lines insurance. Join a dynamic team dedicated to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.