Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Executive Director of Medical Services
$250K - $275K *
Join us to lead clinical operations for a multi-state virtual care team, ensuring high-quality, timely care. This role combines direct patient care, administrative leadership, and strategic oversight...
1 week ago
$88K - $117K *
Join a team that's building robust data infrastructure to transform raw data into actionable insights. This role is vital for developing scalable data models and pipelines, enhancing decision-making a...
1 week ago
$126K - $168K *
Transform the Connected Aircraft portfolio by leading product strategy and execution for Flight Management Systems. Collaborate cross-functionally to drive business growth, align customer needs, and d...
1 week ago
$90K - $110K *
Elevate your career by owning key aspects of month-end close while optimizing AI-driven accounting operations. Collaborate with finance teams to enhance processes and support financial reporting in a...
1 week ago
Integrated Campaign Strategist
$153K - $208K *
Partner with us to architect and execute integrated marketing campaigns that drive enterprise product launches and enhance brand storytelling, ensuring alignment across multiple teams and channels for...
1 week ago
Salesforce Operations Lead #5-7-337
$80K - $95K *
Champion operational excellence by leading Salesforce environments, ensuring technical stability and strategic optimization while collaborating with IT and business stakeholders to drive efficiency an...
1 week ago
Sales Manager - DaySmart Pet & TimeToPet
$150K *
Champion sales excellence by leading and developing high-performing teams, driving revenue growth, and optimizing processes across product lines. Foster a culture of accountability while aligning stra...
1 week ago
$109K - $175K *
Unlock opportunities in Spatial Proteomics by bridging scientific insights with commercial strategies. Collaborate with regional teams to drive sales, engage KOLs, and accelerate market adoption throu...
1 week ago
Principal Systems Studies Engineer - Data Centers
$130K - $155K *
Drive business growth by leading consulting and system studies for T&D infrastructure, focusing on data centers. Engage with industry leaders and ensure high-quality technical solutions while supporti...
1 week ago
$110K - $130K *
Empower your career by leading sales strategies across the US. Collaborate with a dynamic team to drive growth, develop client relationships, and deliver impactful presentations while navigating indus...
1 week ago
$190K - $300K *
Champion scientific exchange and research initiatives in gastrointestinal immunology, engaging with key scientific leaders to enhance understanding and support clinical trials while fostering an inclu...
1 week ago
Strategic Account Executive - Special Programs - Northern California
$105K - $110K *
Unlock your potential as you drive strategic growth in K-12 special education markets. Lead complex sales cycles, build trusted relationships, and shape innovative solutions that enhance educational o...
1 week ago
$180K - $190K *
Deliver innovative solutions by acquiring Fortune 500 clients, leading complex sales cycles, and building executive relationships. Drive value through AI insights and strategic partnerships, ensuring...
1 week ago
$96K - $159K *
Drive your career with a dynamic sales role focused on managing agency relationships, implementing growth strategies, and leveraging advanced analytics to achieve profitability and retention goals in...
1 week ago
$96K - $159K *
Join a team that's driving profitable growth through innovative sales strategies and strong relationships. You'll manage agency territories, optimize performance, and leverage advanced analytics to en...
1 week ago
Associate Director, US Patient Advocacy
$164K - $225K *
Develop and execute patient advocacy strategies, engaging with PAOs and cross-functional teams to elevate the patient voice and ensure successful partnerships for rare disease therapeutic areas...
Reposted 1 week ago
Senior Program Manager, Product Operations
$130K - $160K *
Optimize strategic opportunities by leading cross-functional initiatives and applying AI-driven solutions to enhance business performance, while collaborating with senior leaders to drive impactful ch...
Reposted 1 week ago
Product Marketing Manager (Contractor)
$107K - $171K *
Shape the market narrative for AI Agent Identity by leading product marketing initiatives. Own positioning, messaging, and commercial enablement for DNSid, translating complex innovations into compell...
1 week ago
Supply Chain Network Transformation Manager
$141K - $278K *
Drive supply chain transformation by leading design and optimization projects. Shape strategies, guide client discussions, and manage delivery while enhancing team capabilities and contributing to inn...
1 week ago
Supply Chain Network Transformation Manager
$141K - $278K *
Transform supply chain strategies by leading network design and optimization projects. Collaborate with clients to enhance operational efficiency and drive value through advanced analytics and innovat...
1 week ago
$134K - $265K *
Join a team that's transforming business landscapes by leading Oracle Cloud Financials implementations, driving efficiency, and enhancing decision-making for clients. Collaborate with stakeholders to...
1 week ago
$134K - $265K *
Transform business processes as you lead Oracle Cloud Financials implementations, guiding teams and clients through complex projects while enhancing efficiency and decision-making across organizations...
1 week ago
$110K - $130K *
Join a team that's dedicated to enhancing patient care through clinical pharmacy expertise. Collaborate with healthcare professionals to optimize medication therapy and ensure safe, effective drug use...
1 week ago
$80K - $95K *
Join a team that's dedicated to crafting innovative software solutions. You'll design, develop, and maintain applications while collaborating with peers to ensure best practices and adherence to archi...
1 week ago
$150K - $200K *
Lead client engagements by leveraging tax expertise to drive revenue growth, manage complex planning discussions, and enhance client relationships while ensuring strategic alignment across teams for o...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.