Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$101K - $152K *

Lead the charge in ensuring product excellence by overseeing quality assurance processes, conducting audits, and collaborating with cross-functional teams to enhance product quality and exceed custome...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Optimize contact center strategies by leveraging virtual agent and IVR technologies. Collaborate with stakeholders to enhance operational workflows and drive performance through data analysis and inno...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$229K - $260K *

Transform the integration landscape by architecting robust connections between NodeZero and key security platforms, ensuring reliability and observability while mentoring engineers and driving technic...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Engineer customer reliability by providing expert technical support for IoT solutions. Collaborate with teams to resolve issues, enhance documentation, and gather feedback, ensuring a seamless custome...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$94K - $164K *

Champion cost reporting processes by ensuring data accuracy, preparing detailed reports, and analyzing financial information. Collaborate across departments to enhance reporting systems and support st...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$72K - $115K *

Partner with us to design and validate predictive models that enhance business processes across various domains, leveraging data science techniques to drive insights and improve decision-making within...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$81K - $121K *

Transform retail partnerships by coaching top sellers, driving sales growth, and executing strategic plans to enhance agricultural product adoption and profitability in a dynamic, remote environment...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$136K - $253K *

Elevate your career by leading sales strategies and fostering dealer relationships to achieve market share goals. Drive team success through effective communication and innovative sales tools while ma...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$86K - $137K *

Optimize project outcomes as you manage small to medium-sized initiatives. Collaborate across teams, navigate risks, and ensure timely delivery of quality solutions while enhancing communication and s...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$115K - $158K *

Drive strategies to enhance customer engagement and retention for pharmacy services. Collaborate with cross-functional teams to optimize member experiences, increase auto-refill adoption, and boost pr...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$129K - $177K *

Join a team that's shaping innovative pricing strategies for Medicare Advantage products. Collaborate cross-functionally to analyze market data, establish financial metrics, and drive profitable growt...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$108K - $158K *

Unlock potential by managing key accounts in the entertainment lighting sector. Drive sales growth, nurture relationships, and oversee complex projects from design to delivery, ensuring alignment and...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$126K - $176K *

Lead the charge in shaping innovative lighting solutions by managing a dynamic team, defining market strategies, and building strong relationships with key specifiers to drive business impact and enha...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$87K - $139K *

Optimize trade compliance processes by managing master data and ensuring regulatory readiness. Lead cross-functional collaboration to enhance data accuracy and streamline customs operations, driving e...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $120K *

Drive revenue growth by leading high-performing sales teams and executing strategic sales initiatives. This role combines leadership with deep expertise in performance marketing to achieve ambitious b...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$95K - $113K *

Manage project lifecycles to exceed client expectations, ensuring timely communication and risk management while fostering collaboration and mentoring within teams to achieve project goals and profita...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$77K - $91K *

Shape the future of project management by leading initiatives that exceed expectations, ensuring timely communication, and fostering collaboration across teams while managing risks and delivering resu...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $140K *

Unlock potential by leading the design and governance of structured exam content. Drive standards compliance and metadata alignment across assessment systems, ensuring seamless integration and functio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $130K *

Drive community engagement by managing digital resources and support for educators. Oversee outreach programs, content channels, and strategic growth initiatives to enhance user experience and foster...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$165K - $190K *

Champion client engagement and project management while leading ERP implementations in higher education and public sectors. Drive financial optimization and mentor teams to deliver impactful solutions...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$120K - $170K *

Join a team that's driving growth in government sales by leading strategic initiatives with the FAA. This role focuses on expanding business opportunities and fostering relationships across complex av...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$110K - $130K *

Accelerate progress at the forefront of cybersecurity by leading threat hunting initiatives. Engage with clients to deliver tailored IT solutions, analyze complex data, and enhance security measures i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$80K - $105K *

Unlock your potential by leading branch operations, driving strategic initiatives, and enhancing team performance. Collaborate with stakeholders to achieve financial goals while fostering a culture of...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$160K - $180K *

Transform the user experience by leading innovative product strategies for a tech-driven learning platform. Drive AI initiatives, collaborate with cross-functional teams, and mentor product managers t...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Transform power generation strategies by leading innovative solutions and optimizing energy contracts. Drive collaboration across teams to enhance project management and accelerate market readiness fo...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.